epileptic

Question 1

carbamazepine

Answer 1

na block
focal seizure* general tonic clinic trigeminal neuralgia and bipolar disorder
CYP inducer
hyponatremia/stevenjohnson syndrome/blood dyscrasia

Question 2

eslicarbazepine

Answer 2

block na

partial onset seizures in adults

Question 3

ethosuximide

Answer 3

T-type ca inhibited

only absence seizures

Question 4

ezogabine

Answer 4

open m type k channels

QT prolongation blue skin discolor retina changes

Question 5

BZD

Answer 5

bind to gaba inhibitoryreceptors
avoid gen tonic clonic
clonazepam diazepam clobazam

Question 6

felbamate (BROAD)

Answer 6

block na glycine(NMDA),Ca
inc GABA 
CYP2C19 inhibitor 
CYP3A4 inducer
used in REFRACYIVE EPILEPSY(Lennox gas taut syndrome)APLASTIC ANEMIA AND HEPATIC FAILURE

Question 7

GABAPENTIN

Answer 7

enhance gaba
FOCAL SEIZURES TRIGEMINAL NEURALGIA adjunct
OLD people PARTIAL SEIZURES

Question 8

lacosamide

Answer 8

block na
bind to CRMP-2(collapsin)
treat FOCAL SEIZURES

Question 9

CRMP-2

Answer 9

PHOSPHOPROTEIN INVOLVED IN NEURONAL DIFFRENTIATION AND CONTROL OF AXONAL OUTGROWTH

Question 10

LAMOTRIGINE(B)

Answer 10

Block ca and na
wide types-focal ,general ,absence,lennox gestalt and bipolar.
metabolism UGT PATHWAY

Question 11

UDP METABOLISM DRUGS

Answer 11

DIVAPREX
EZOGABINE
LAMOTRIGINE
LORAZEPAM

Question 12

LEVITIRACETAM(B)

Answer 12

adjunct FOCAL ONSET
MYOCLONIC
PRIMARY TONIC CLONIC
high affinity to synaptic vesicle protein(SVA2)
mood alter

Question 13

Oxcarbazepine

Answer 13

PRODRUG reduce to MHD
block na and ca in children and adults
PARTIAL ONSET SEIZURE hyponatremia limits use in elderly

Question 14

Perampanel

Answer 14

partial onset seizures in 12 years old

Question 15

PHENOBARBITOL AND PRIMIDONE

Answer 15

Enhance GABA
primi to phenobarbitals
treat STATUS EPILEPTICUS

Question 16

STATUS EPILEPTICUS

Answer 16

two or more seizures occurs without recovery of full consciousness in between episodes
give bzd the phenytoin

Question 17

STEVEN JOHNSON INDUCIING DRUGS

Answer 17

P heno
C aram
P hey
L amor
A llo
P eni
S ulfa
E myth

Question 18

PHENYTOIN

fosphenytoin (pro)

Answer 18

block na
treat FOCAL GEN AND SATTUS ELLIPTICUS
CYP inducers
gingival hyperplasia/neuropathies/ataxia/osteoporosis

Question 19

Pregabalin

Answer 19

binds to alpha-delta of  calcium block
treat FOCAL ONSET
POSTHERPETIC NEURALGIA
FIBROMYALGIA
renal toxic/weight/edema

Question 20

Rufinamide

Answer 20

TREAT LENNAUX GESTAUT OVER 4 YRS

short QT syndrome common

Question 21

LENNAUX GASTAUT SYNDROME

divaproleux/lamotrigine/topiramate

Answer 21

is a severe form of epilepsy that typically becomes apparent during infancy or early childhood. Affected children experience several different types of seizures most commonly atonic, tonic and atypical absence seizures.

Question 22

TIGABINE

Answer 22

Block gaba uptake

treat PARTIAL ONSET SEIZURES

Question 23

TOPIRAMATE(B)

Answer 23

BLOCK Ca Na CARBONIC ANHYDRASE INHIBITOR,NMDA
TREAT PARTIAL AND PRIMARY GENRERALIZED EPILEPSY also migrane
INHIBITS CYP2C19
SIDE EFFECTS-WEIGHT LOSS/RENAL STONES/HYPERTHERMIA/GLAUCOMA

Question 24

VALPROIC ACID /DIVAPROLEUX

Answer 24

block na and gaba transaminase
treat focal and primary generalized
inhibit CYP/UGT and epoxide hydroxyls

Question 25

VIGABATRIN

Answer 25

IRREVERSIBLE inhibitor of GABA-T | visual field loss

Question 26

ZONISAMIDE(B)

Answer 26

block na and T-Ca has carbonic anhydrase activity treat FOCAL EPILEPSY KIDNEY STONES/OLIGOHYDROSIS

Question 27

FOCAL

Answer 27

SIMPLE PARTIAL COMPLEX PARTIAL LAMOTRIGINE LEVITERACETUM TOPIRAMATE

Question 28

SIMPLE PARTIAL

Answer 28

NO LOSS of conciousness | one limb movement

Question 29

complex partial

Answer 29

sensory hallucinations motor dysfunction mental distortion

Question 30

generalized seizures

Answer 30

tonic clonic absence myoclonic atonic

Question 31

tonic clonic

Answer 31

``` loss of conciousness cont contraction and rapid cont and relaxation hypoglycemic LAMOTRIGINE LEVITERACETUM TOPIRAMATE ```

Question 32

absence

Answer 32

brief abrupt self limiting loss of consciousness atare and rapid eyeblinking from 3-5 years of age for 3 sec divaproex/limotrigine

Question 33

myoclonic

Answer 33

brief jerks of limbs 3-5 mins divaproex/levitiracetum

Question 34

atonic

Answer 34

drop attacks | sudden loss of muscle tone

Question 35

west syndrome

Answer 35

infantile spasms CORTICOTROPHIN VIGABACTRIN

Question 36

BENIGN ROLANDIC

Answer 36

gabapentin | lamotrigine