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pharm antiepileptics > epileptic > Flashcards

epileptic Flashcards

1
Q

carbamazepine

A

na block
focal seizure* general tonic clinic trigeminal neuralgia and bipolar disorder
CYP inducer
hyponatremia/stevenjohnson syndrome/blood dyscrasia

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2
Q

eslicarbazepine

A

block na

partial onset seizures in adults

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3
Q

ethosuximide

A

T-type ca inhibited

only absence seizures

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4
Q

ezogabine

A

open m type k channels

QT prolongation blue skin discolor retina changes

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5
Q

BZD

A

bind to gaba inhibitoryreceptors
avoid gen tonic clonic
clonazepam diazepam clobazam

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6
Q

felbamate (BROAD)

A 
block na glycine(NMDA),Ca
inc GABA 
CYP2C19 inhibitor 
CYP3A4 inducer
used in REFRACYIVE EPILEPSY(Lennox gas taut syndrome)APLASTIC ANEMIA AND HEPATIC FAILURE
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7
Q

GABAPENTIN

A

enhance gaba
FOCAL SEIZURES TRIGEMINAL NEURALGIA adjunct
OLD people PARTIAL SEIZURES

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8
Q

lacosamide

A

block na
bind to CRMP-2(collapsin)
treat FOCAL SEIZURES

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9
Q

CRMP-2

A

PHOSPHOPROTEIN INVOLVED IN NEURONAL DIFFRENTIATION AND CONTROL OF AXONAL OUTGROWTH

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10
Q

LAMOTRIGINE(B)

A

Block ca and na
wide types-focal ,general ,absence,lennox gestalt and bipolar.
metabolism UGT PATHWAY

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11
Q

UDP METABOLISM DRUGS

A

DIVAPREX
EZOGABINE
LAMOTRIGINE
LORAZEPAM

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12
Q

LEVITIRACETAM(B)

A 
adjunct FOCAL ONSET
MYOCLONIC
PRIMARY TONIC CLONIC
high affinity to synaptic vesicle protein(SVA2)
mood alter
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13
Q

Oxcarbazepine

A

PRODRUG reduce to MHD
block na and ca in children and adults
PARTIAL ONSET SEIZURE hyponatremia limits use in elderly

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14
Q

Perampanel

A

partial onset seizures in 12 years old

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15
Q

PHENOBARBITOL AND PRIMIDONE

A

Enhance GABA
primi to phenobarbitals
treat STATUS EPILEPTICUS

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16
Q

STATUS EPILEPTICUS

A

two or more seizures occurs without recovery of full consciousness in between episodes
give bzd the phenytoin

17
Q

STEVEN JOHNSON INDUCIING DRUGS

A 
P heno
C aram
P hey
L amor
A llo
P eni
S ulfa
E myth
18
Q

PHENYTOIN

fosphenytoin (pro)

A

block na
treat FOCAL GEN AND SATTUS ELLIPTICUS
CYP inducers
gingival hyperplasia/neuropathies/ataxia/osteoporosis

19
Q

Pregabalin

A 
binds to alpha-delta of  calcium block
treat FOCAL ONSET
POSTHERPETIC NEURALGIA
FIBROMYALGIA
renal toxic/weight/edema
20
Q

Rufinamide

A

TREAT LENNAUX GESTAUT OVER 4 YRS

short QT syndrome common

21
Q

LENNAUX GASTAUT SYNDROME

divaproleux/lamotrigine/topiramate

A

is a severe form of epilepsy that typically becomes apparent during infancy or early childhood. Affected children experience several different types of seizures most commonly atonic, tonic and atypical absence seizures.

22
Q

TIGABINE

A

Block gaba uptake

treat PARTIAL ONSET SEIZURES

23
Q

TOPIRAMATE(B)

A

BLOCK Ca Na CARBONIC ANHYDRASE INHIBITOR,NMDA
TREAT PARTIAL AND PRIMARY GENRERALIZED EPILEPSY also migrane
INHIBITS CYP2C19
SIDE EFFECTS-WEIGHT LOSS/RENAL STONES/HYPERTHERMIA/GLAUCOMA

24
Q

VALPROIC ACID /DIVAPROLEUX

A

block na and gaba transaminase
treat focal and primary generalized
inhibit CYP/UGT and epoxide hydroxyls

25
Q

VIGABATRIN

A

IRREVERSIBLE inhibitor of GABA-T

visual field loss

26
Q

ZONISAMIDE(B)

A

block na and T-Ca
has carbonic anhydrase activity
treat FOCAL EPILEPSY
KIDNEY STONES/OLIGOHYDROSIS

27
Q

FOCAL

A

SIMPLE PARTIAL COMPLEX PARTIAL
LAMOTRIGINE
LEVITERACETUM
TOPIRAMATE

28
Q

SIMPLE PARTIAL

A

NO LOSS of conciousness

one limb movement

29
Q

complex partial

A

sensory hallucinations
motor dysfunction
mental distortion

30
Q

generalized seizures

A

tonic clonic
absence
myoclonic
atonic

31
Q

tonic clonic

A 
loss of conciousness
cont contraction and rapid cont and relaxation
hypoglycemic
LAMOTRIGINE
LEVITERACETUM
TOPIRAMATE
32
Q

absence

A

brief abrupt self limiting loss of consciousness
atare and rapid eyeblinking
from 3-5 years of age for 3 sec
divaproex/limotrigine

33
Q

myoclonic

A

brief jerks of limbs
3-5 mins
divaproex/levitiracetum

34
Q

atonic

A

drop attacks

sudden loss of muscle tone

35
Q

west syndrome

A

infantile spasms
CORTICOTROPHIN
VIGABACTRIN

36
Q

BENIGN ROLANDIC

A

gabapentin

lamotrigine

pharm antiepileptics (5 decks)

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