Epinephrine 1:1000

Question 1

Epinephrine 1:1000
Classification

Answer 1

Sympathomimetic
Sympathetic agonist
Catecholamine

Question 2

Epinephrine 1:1000
Mechanism of Action

Answer 2

-a1 agonist: second messenger release of calcium in VSMC, peripheral vasoconstriction, increased SVR, increased BP
-b1 agonist: increased intracellular Ca in cardiac cells, positive inotropy, chronotropy, dromotropy
-b2 agonist: bronchial smooth muscle relaxation, bronchodilation
-Blocks realse of calcium in and subsequent destruction of MAST cells

Question 3

Epinephrine 1:1000
Onset of action

Answer 3

<2 min IV
3-10 min IM

Question 4

Epinephrine 1:1000
Peak Effects

Answer 4

<5 min IV
20 min IM

Question 5

Epinephrine 1:1000
Duration of Effect

Answer 5

5-10 min IV
20-30 min IM

Question 6

Epinephrine 1:1000
Half-life

Answer 6

5 min IV

Question 7

Epinephrine 1:1000
Indications/Field Use

Answer 7

Cardiac Arrest
Anaphylaxis/Severe Reactive airway desease/asthma
Symptomatic bradycardia/hypotension

Question 8

Epinephrine 1:1000
Contraindications

Answer 8

Tachydysrhythmias

Question 9

Epinephrine 1:1000
Side Effects/Adverse Reactions

Answer 9

Anxiety
HA
Dysrhythmias
Tremulousness
Dizziness
N/V

Question 10

Epinephrine 1:1000
Adult Dose

Answer 10

Anaphylaxis/Asthma 0.3-0.5mg IM (1:1000)

Question 11

Epinephrine 1:1000
Pedi Dose

Answer 11

Anaphylaxis/Asthma 0.01mg/kg IM (1:1000) max 0.3mg

Question 12

Epinephrine 1:1000
Precautions

Answer 12

-Should be protected from light, caution with CAD and pregnancy
-Leads to increased myocardial oxygen demand

Question 13

Epinephrine 1:1000
Drug-drug interactions

Answer 13

-pH dependent, deactivated by alkaline solutions
-effects intensified with pts taking antidepressants
-reacts with CaCl and NaHCO to form PPT (in IV tubing)