Epithelial Surface Specializations Flashcards Preview

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Flashcards in Epithelial Surface Specializations Deck (48):
1

Microvilli

cell membrane invaginations to increase surface area, in stomach and kidney, use actin

2

terminal web

bottom of the microvilli, binds to actin, can contract

3

stereocilia

long micrvilli, present in epididymis and inner ear, functions for absorbtion and mechanosensory

4

cilia and flagella

motile apical projections, contain microtubules, in trachea and bronchi and oviducts

5

basal bodies

anchors cilia

6

axoneme

9X2+2 structure of microtubules in cilia

7

dynein

motor protein of cilia, powered by ATP

8

Kartagener syndrome (immotile ciliary syndrome)

absence of dyenin arms, problem with mucus clearing and fertility, also situs inversus, bronchiectasis and chronic sinusitus

9

glycocalyx

carbohydrate residues outside of cells, well developed in cells with microvilli

10

Junctional complex

made up of zonula occludens, zonula adherens, and desmosomes,

11

terminal bar

darkly stained structure made up of the junctional complex

12

Zonula occuldens

tight junctions, form a selective barrier, prevent membrane proteins from moving to lateral side, regulate the apical border seal

13

Claudin, occludin

makes up tight junctions

14

Zonula adherens

confers adherence between cells, uses cadherins and actin, responds to stretching of cells

15

E-cadherin

component of zonula adherens

16

desmosomes

macula adherens, fasten cells to one another, spot welds, uses keratin filaments, desmoglein and desmocollin

17

keratin intermediate filaments

important in desmosomes

18

Desmogelin, desmocolin

adhesive components of desmosomes

19

pemphigus

autoimmunity against desmoglein components of desmsomes, results in blistering

20

impetigo

Staph infection that attacks desmoglein proteins of desmosomes, results in blisters (serine protease)

21

Gap junction

Cell communication allows passage of ions and chemical/electrical signals

22

connexon

protein used in forming a gap function

23

Hemidesmosome

involved in adhering cell to basal membrane, uses integrins and collagen type XVII

24

integrin

involved in hemidesmosomes

25

tonofilaments

associated with desmosomes and hemidesmosomes, made of keratin

26

collagen type IV

component of the basal lamina

27

Collagen type III

component of the reticular lamina

28

Collagen type VII

connects colagen 3 to collagen 4

29

bullous pemphigoid

autoimmune reaction against hemidesmosomes (collagen 17), leads to blistering

30

basal infoldings

involved in ion transport and water movement, involve mitochondria, increases surface area

31

basal outfolding

found in SSKE of skin for increasing surface area

32

striated border

same as brush border, comprised of microvilli and important for absorbtion or secretion

33

Primary cilia dyskinesia

affecting dyenin arms of proteins (cilia), leads to complications in lungs (mucous clearance), ears (mucous clearance), and fertility

34

transmembrane proteins of tight junctions

occludin and claudin

35

cytoskeletal proteins of tight junctions

actin

36

Intracellular peripheral membrane proteins of tight junctions

ZO1, ZO2, ZO3, cingulin

37

zonulin

loosens tight junctions to allow water to expel bacteria in intestine

38

transmembrane protein of zonula adherens

Cadherins (E-cadherin)

39

cytoskeleton proteins of zonula adherens

actin

40

transmembrane proteins of desmosomes

cadherins - desmoglein and desmocollin

41

peripheral membrane proteins of desmosomes

plakoglobin and desmoplakin

42

cytoskeleton proteins of desmosomes

keratin

43

transmembrane proteins of gap junctions

connexins and connexons

44

transmembrane proteins of hemidesmosomes

integrins and collagen XVII

45

peripheral proteins of hemidesmosomes

plectin BP230

46

cytoskeletal proteins of hemidesmosomes

keratin (tonofilaments)

47

Junctional Epidermolysis bullosa

mutations in anchoring filaments (laminin 5)

48

Dystrophic epidermolysis bullosa

mutations in collagen 7