Estrogens and progestins

Question 1

most potent natural estogen

Answer 1

estradiol

Question 2

estrogen drug with first pass effect

Answer 2

estradiol

Question 3

administration of estradiol

Answer 3

oral, transdermal, transvaginal

Question 4

equine conjugated estrogen

Answer 4

estrone

Question 5

most common estrogen therapy

Answer 5

estrone

Question 6

used for vasomotor sx of estrigen deficiency

Answer 6

cenestin (synthetic estrogen)

Question 7

pro-drug concerted to ethynyl estradiol

Answer 7

mestranol

Question 8

increased risk of vaginal/cervical adenocarcinoma

Answer 8

DES

Question 9

non-steroidal estrogen

Answer 9

DES

Question 10

uses of estrogens

Answer 10

OCP
menopause
Osteoporosis
breast cancer
prostate cancer

Question 11

uses of estrogens that may have high risks

Answer 11

menopause and osteoporosis

Question 12

adverse effects of estrogens

Answer 12

nausea
breast engorgement
endometrial hyperplasia and cancer
birth defects
possibly headaches and breast cancer

Question 13

competetive estrogen antagonists

Answer 13

clomiphene and tamoxifen

Question 14

inhibitors of estrogen sythesis

Answer 14

leuprolide and GnRH analogs

Question 15

physiological antagonists

Answer 15

progestins and androgens

Question 16

tamoxifen class

Answer 16

SERM

Question 17

MOA of tamoxifen

Answer 17

competive partial agonist of estrogen in the breast - blocks the receptor

Question 18

adverse effects of tamoxifen

Answer 18

may increase endometrial cancer
vasomotor sx
n/v

Question 19

tissue at which tamoxiphen is BOTH more efficious and more potent

Answer 19

endometrium

Question 20

tissue at which tamoxiphen is less efficious and more potent

Answer 20

breast

Question 21

SERM used for postmenopausal osteoporosis

Answer 21

raloxifine

Question 22

effects of raloxafine

Answer 22

estrogenic effect on bone

antogonstic effect on uterus and breast

Question 23

infertility drugs

Answer 23

hMG/hCG

clomiphene

Question 24

administration of hMG/hCG

Answer 24

IM

Question 25

effect of hMG

Answer 25

increases FSH and LH to stimulate follicular development and maturation

Question 26

effect of hCG

Answer 26

LH surge increases ovulation

Question 27

confirms ovulation

Answer 27

progesterone

Question 28

pregancy rate for hMG/hCG

Answer 28

50%

Question 29

oral infertility drug

Answer 29

clomiphene

Question 30

blocks Estrogen receptors in feedback loop

Answer 30

clomiphene

Question 31

SE of infertility treatment

Answer 31

abdominal pain ovarian cyst rupture multiple kids

Question 32

infertility drug more likely to give multiple births

Answer 32

hMG/hCG

Question 33

use of IM progesterone

Answer 33

endometrial/renal cancer amenorrhea, abnormal uterine bleeding IUDs

Question 34

synthetic long-lasting progesterone

Answer 34

medroxyprogesterone

Question 35

use of medroxyprogesterone

Answer 35

injectable contraceptive

Question 36

SE of medroxyprogesterone

Answer 36

irregular bleeding, possible lowered bone density

Question 37

racamatic OC progesterone component

Answer 37

norgestrel

Question 38

sub-dermal OC (norplant)

Answer 38

levonorgestrel

Question 39

norethindrone

Answer 39

Prosterone in OCPs

Question 40

ethynodiol diaetate

Answer 40

progesterone OCPs

Question 41

uses of progetrins

Answer 41

OCP dysfunctional uterine bleeding endometrosis endometrial, breast, renal cancer

Question 42

adverse effects of progestrins

Answer 42

abnormal menstrual bleeding | weight gain, demema, depression

Question 43

contraindications of progestrins

Answer 43

pregnancy

Question 44

MOA of mifepristone

Answer 44

competitive antagonist at progesterone and glucocorticoid receptors

Question 45

use of mifepristone

Answer 45

abortion

Question 46

possible uses of mifepristone

Answer 46

meningioma, breast cancer, cushings, glaucoma

Question 47

estogens in combo OCPs

Answer 47

ethinyl estradiol/mestranol

Question 48

progestins in Combo OCPs

Answer 48

``` norgesterel levonorgesterel norethindrone ethyndiol diacetate desogesteral norgestimate drospireone ```

Question 49

progerterin in Yaz

Answer 49

drospirenone

Question 50

MOA of combo OCP

Answer 50

supression of ovulation | changes in cervical mucus and endometrium

Question 51

use of mini-pilla

Answer 51

when Combo OCPs and contraindicated or not tolerated

Question 52

SE of emergency contraception

Answer 52

n/v breast tenderness

Question 53

drugs in emergency contraception

Answer 53

levonorgestrel and ethinyl estradiol

Question 54

drugs in plan B

Answer 54

levonorgesteral

Question 55

OCP side effects

Answer 55

thromboit effects MI hypertension cancer??

Question 56

OCP + this is bad news

Answer 56

smoking