Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Endocrine > thyroid drugs > Flashcards

thyroid drugs Flashcards

1. Describe the synthesis and release of thyroid hormone and describe the relationship between T3 and T4 in terms of production, potency, protein binding, and metabolism. 2. Describe the rationale for the approaches used in the pharmacological treatment of hyperthyroidism. 3. List the prototype oral drugs used to treat hyperthyroidism, describe their mechanism of action and list their major side effects and clinical uses. 4. Explain the source and function of circulating iodide and its dual a (39 cards)

Start Studying
1
Q

Levothyroxine

A

Thyroid replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

liothyronine

A

Thyroid replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

liotrix

A

Thyroid replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

thyroglobulin

A

Thyroid replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

DOC for hypothyroidism

A

levothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

levothyroxine mimics

A

T4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

liothyronine

A

T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

issue with generic levothyroxines

A

different generics are absorbed at different rates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

rapid onset, short DOA Thyroid replacement

A

liothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

can cause myxedema coma

A

liothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

can be cardiotoxic

A

liothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

mixture of T3 and T4

A

liotrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

purified hog thyroid extract

A

thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

instable, variable product that can cause antigenic issues

A

thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

most potent Thyroid replacement

A

liothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

general SE of Thyroid replacement drugs

Study These Flashcards
A

hyperthyroidism

CV side effects

17
Q

population needed to be cautious with with Thyroid replacement drugs

Study These Flashcards
A

elderly, esp with CV disease

18
Q

MOA of Propylthiouracil

Study These Flashcards
A

interferes with deionization of T4 into Active T3

19
Q

organification

Study These Flashcards
A

creating I2 out of ionized Iodine

20
Q

coupling

Study These Flashcards
A

DIT to T4 step

21
Q

hormone created by the thyroid

22
Q

active thyroid hormone

23
Q

MOA of thioamides in general

Study These Flashcards
A

prevents synthesis of active T3 by blocking organification, coupling or deiodination

24
Q

SE of thioamides in general

Study These Flashcards
A

skin rash, headache, nausea, leukopenia, agranulocytosis

25
MOA of iodides
decreases the size and vascularity of the hyperplastic thyroid gland. blocks organification and release of T4
26
drug to use before thyroid removal
iodide
27
contraindications to iodides
use before I 131
28
increased iodine stores will
delay thionamide onset
29
withdrawal of iodide therapy can
precipitate thyrotixicosis
30
iodide drugs (3)
lugol's solution, KI Sodium ipodate
31
used to asess thyroid responsiviness
Radioactive iodide
32
destroys iodide tissues
I 131
33
suppresses clinical sx of hyperthyroidism
propranolol
34
use of propranolol in thyroid dx
shortterm until definitive therapy
35
steps of Thyroid hormone biosynthesis
trapping, organification, incorporation, coupling, proteolysis and release
36
intermediate thyroid hormone products
``` thyroglobiln MIT DIT T4 T3 ```
37
T4 converted to T3 where?
bloodstream
38
amino acid used in thyroid hormone sythesis
thyrosine
39
effect of THs and catcholamines
potientate each other

Endocrine (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions