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Ortho 1 > Euflexxa > Flashcards

Euflexxa Flashcards

(45 cards)

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1
Q

Which of the following bones is not part of the knee?

  • Tibia
  • Femur
  • Radius
  • Patella
A

Radius

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2
Q

What type of biomechanical factors can predispose an individual to knee osteoarthritis? (select all that apply)

  • Knee Injury
  • Occupations involving excessive bending
  • Malalignment of the knee
A
  • Knee injury
  • Occupations involving excessive bending
  • Malalignemnt of the knee
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3
Q

Which of the following is the most common adverse event related to intra-articular hyaluronic acid?

  • Vomiting
  • Injection-site reactions
  • pseudosepsis
  • Headache
A
  • Injection-site reactions
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4
Q

The ____ is the most commonly involved joint in osteoarthritis?

  • Ankle
  • Hip
  • knee
  • Elbow
A

Knee

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5
Q

Studies have demonstrated that a ____ weight loss is associated with a 50% reduction in the risk for developing symptomatic knee osteoarthritis?

  • 2.5-kg (5.5lb)
  • 7.5kg(16.5lb)
  • 5kg(11lb)
  • 10kg(22lb)
A

5kg (11lb)

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6
Q

True or False? Patients can receive an unlimited number of intra-articular corticosteroid injections each year without damaging the articular cartilage.

A

False

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7
Q

True or False? In the knee, the femoropatellar joint acts primarily as a hinge joint to allow flexion and extension?

A

False

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8
Q

Which of the following is the most common type of joint in the body?

  • Synovial
  • Gomphosis
  • Cartilaginous
  • Fibrous
A

Synovial

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9
Q

True or False? In a process called weeping lubrication, synovial fluid is forced out from the articular cartilage during joint compression and seeps back in when the compression ceases.

A

True

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10
Q

True or False? Articular cartilage lacks nerve fibers, blood vessels, and lymphatic tissues, resulting in a limited capability for healing and repair.

A

True

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11
Q

True or False? In osteoarthritis, inflammatory mediators disrupt the synthesis of hyaluronic acid and proteinases cleave the hyaluronic acid molecules into lower MW molecules.

A

True

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12
Q

Which of the following are common physical findings of knee osteoarthritis? (Select all that apply)

  • Mediolateral instability
  • Increased joint flexion
  • increased warmth
  • Crepitus
A

Mediolateral instability
Increased Warm
Crepitus

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13
Q

Which of the following components of the synovial joints is the fluid that occupies all free space in the articular capsule?

  • Pleural Fluid
  • Synovial Fluid
  • Extracellular Fluid
  • Amoniotic Fluid
A

Synovial Fluid

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14
Q

Which of the following are distinguishing features of a synovial joints?

  • Joint Cavity
  • Elastic Cartilage
  • Ligaments
  • Articular Capsule
A

Joint Cavity
Ligaments
Articular Capsule

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15
Q

The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) consists of 24 items that are divided into which of the following subscales? (Select all that apply)

  • Quality of Life
  • Stiffness
  • Physical Function
  • Pain
A

Stiffness
Physical function
Pain

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16
Q

EUFLEXXA is an ____ injectable.

  • Intra-vascular
  • Intra-venous
  • Intra-Articular
  • Intra-muscular
A

Intra-articular

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17
Q

EUFLEXXA is indicated for the treatment of ____ in osteoarthritis of the knee.

  • Swelling
  • pain
  • infection
  • inflammation
A

Pain

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18
Q

Results of the pivotal study (published by Drs. Kirchner and Marshall) showed that EUFLEXXA provided______ safety and efficacy when compared to the cross-linked competitor, meeting the primary end point.

  • Equivalent
  • Inferior
  • non-inferior
  • Superior
A

-Non inferior

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19
Q

The ___ assessed the safety and effectiveness of Euflexxa therapy for knee osteoarthritis for 26 weeks.

  • FLEXX Trial
  • Pivotal Study (results published by Dris. Kirchner and Marshall)
  • FLEXX trial extension study
  • None
20
Q

Results of the FLEXX trail extension study showed that the most frequent treatment-related adverse events were _______.

  • Joint swelling, Headache, Fatigue, and diarrhea
  • Nausea, Arthralgia, Cough, and Hypertension
  • Arthralgia, joint swelling, Peripheral edema, and injection site pain
  • Headache, nausea, fatigue, and dizziness
Study These Flashcards
A

Arthralgia, joint swelling, Peripheral edema, and injection site pain

21
Q

True or False? in the FLEXX Trial there were no joint effusions reported as adverse events in the EUFLEXXA group.

22
Q

Results of the FLEXX Trial showed that the EUFLEXXA group had a __ median % reduction in pain from baseline, while the buffered saline group had a __ median % reduction in pain from baseline.

  • 53%,38%
  • 73%,51%
  • 45%, 23%
  • 67%,44%
23
Q

True or False? HA is more viscous with low joint stress, but it becomes more elastic when joint stress is increased.

24
Q

Synvisc, which is a cross-linked structure of intra-articular hyaluronic acid, has a molecular weight of around ___ million Da.

  • 3.6
  • 6.0
  • .5
  • 9.2
25
The pivotal study (results published by Drs. Kirchner and marshall) was a _____ study that evaluated patients with confirmed osteoarthritis of the knee. - Open -label, multicenter - Prospective, Single center, randomized, double-blind - prospective, multicenter, randomized, double blind - retrospective, single center
prospective, multicenter, randomized, double blind
26
Results of the pivotal showed that the incidence of joint effusion was significantly higher in the cross-linked hyaluronan (CL-HA) group than in the EUFLEXXA group, with 15 episode in __patents of the CL-HA group and 1 episode in 1 patent for the EUFLEXXA group. - 13 - 15 - 9 - 7
13
27
Results of the pivotal study showed that __ of patients in the EUFLEXXA group were symptom free compared to ___ in the cross-linked hyaluronan (CLHA) group. - 46%, 39% - 75%, 61% - 63%, 52% - 59%, 47%
- 63%,52%
28
Hyaluronic acid binds to which cell surface receptor listed below? - CD44 - CD4 - CD28 - CD80
- CD44
29
True or False? In the pivotal study, the five WOMAC subscales used to assess outcomes were: 1. Walking on a flat surface, 2. going up and down stairs, 3. resting during the night, 4. sitting or lying , and 5. standing upright.
True
30
``` Results of the pivotal study showed that over the full study period, patients in the _______ group used significantly more acetaminophen tablets as rescue medication than patients in the _____ group. - EUFLEXXA, single chain - single-chain, Synvisc - Crosslinked HA, EUFLEXXA -EUFLEXXA, crosslinked - ```
Crosslinked HA, EUFLEXXA
31
Which of the following is one of the most common adverse events for Supartz? - Hypertension - Arthralgia - Nausea - Infection
-Arthralgia
32
Which of the follow intra-articular hyaluronic acid products is manufactured by bacterial fermentation? - Monovisc - Gel-One - Supartz - Synvisc
- Monovisc
33
The safety and effectiveness of intra-articular injections of hyaluronic acid has not been established in which of the following patient populations? (Select all that apply). - Geriatrics - Pediatrics - Pregnant Women - Adults
Pediatrics | Pregnant women
34
What are the potential consequences of discussing profitability with customers? - Suspension without pay - 100 fine - Immediate dismissal - Community service
Immediate dismissal
35
Synvisc, which is a cross-linked structure of intra-articular hyaluronic acid, has a molecular weight of around ___ million Da
6.0
36
True or False? The safety and effectiveness of intra-articular hyaluronic acid have been established for locations other than the knee.
False
37
Hyalgan is administered by ___ intra-articular injections. (Select all that apply) - 2 - 1 - 3 - 5
3 and 5
38
True or False? A joint effusion does not need to be removed before an intra-articular injection of hyaluronic acid.
False
39
Concomitant use of disfectants containg quaternary ammonium salts for skin preparation should be avoided with which of the following intra-articular products? - Monovisc - Synvisc - Hyalgan - All of the above
- All of the above
40
Which of the following intra-articular hyaluronic acid products has an injection volume of 6ml? - Monovisc - Synvisc-One - Hyalgan - Supartz
Synvisc-One
41
Monovisc has contraindications to which of the following? (selection all that apply) - Systemic Bleed disorders - Infections or skin diseases in the area of the injection site or joint - Joint effusion - Hypersensitivity to hyaluronate preparations
- Systemic Bleed disorders - Infections or skin diseases in the area of the injection site or joint - Hypersensitivity to hyaluronate preparations
42
Gel-One is extracted from which of the following sources? - Bacterial Cells - Porcine nasal Cartilage - Bovine tracheal Cartilage - Chicken Comb
- Chicken Comb
43
Intra-articular hyaluronic acid products are approved for the treatment of ____ in patient who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics. - Osteoarthritis of the knee and hip - Osteoarthritis of the hand - Inflammation of osteoarthritis of the knee - Pain in osteoarthritic of the knee
Pain in osteoarthritis of the knee
44
Which of the follow is a contraindication of the class of intra-articular hyaluronic acid products? ( Select all that apply)
- Do not administer to patients with known hypersensitivity to sodium hyaluronic preparations - Do not inject in the knees of patients with infections or skin disease or infections in the area of the injection site
45
Intra-articular hyaluronic acid products prepared by animal extractions should be used with caution which of the following allergies. (select all that apply) - Gram positive bacterial proteins - Feathers - Egg products - Avain proteins
- Feathers - Egg products - Avain proteins

Ortho 1 (2 decks)

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