Flashcards in Everything Deck (51)
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1
HLA A3
Hemochromatosis
2
HLA B27
Psoriatic Arthritis, Ankylosing spondylitis, arthritis of IBD, Reactive arthritis (PAIR - seronegative arthropathies)
3
DQ2/DQ8
Celiac disease
4
DR2
MS, hay fever, SLE, Goodpasture
5
DR3
DM1, SLE, Graves Disease, Hashimoto thyroiditis
6
DR4
Rheumatoid arthritis, DM1
7
DR5
Pernicious anemia (vitamin B12 def), Hashimoto thyroiditis
8
What cell has CD40R / what cell has CD40L
CD40 Receptor = B cell, CD40L = Th cell (B cell activation and class switching)
9
What cell has CD28, What cell has B7?
CD28 = Naive T cell, B7 = dendritic cell (Naive T cell activation)
10
C1 esterase inhibitor deficiency
hereditary angioedema (no ACEi!)
11
C3 deficiency
severe, recurrent pyogenic sinus/respiratory tract infections, increase susceptibility to T3HS rxns
12
C5-C9 deficiency
Susceptibility to recurrent Neisseria bacteremia
13
DAF (GPI anchored enzyme, CD55) deficiency
Complement mediated lysis of RBCs, paroxysmal nocturnal hemoglobinuria
14
IL-1 (osteoclast activating factor??)
Fever (HOT), activates endothelium to express adhesion molecules, induces chemokine secretion to attract WBCs
15
IL-2
stimulates T cells (Th, Tc, Treg, NK), can be secreted by T cells or macrophages
16
IL-3
stimulates Bone marrow stem cell growth and differentiation (like GM-CSF)
17
IL-4
stimulates IgE production, promotes Th2 differentiation, B cell growth
18
IL-5
stimulates IgA production, promotes differentiation of B cells, growth and differentiation of eosinophils
19
IL-6
Fever, stimulates production of acute phase reactants
20
IL-8
chemotactic factor for neutrophils (clean up on aisle 8!)
21
IL-12
induce differentiation of T cells into Th1, activate NK cells
22
TNF-alpha
Mediates septic shock, activates endothelium, WBC recruitment, vascular leak (cachexia in malignancy)
23
IFN-Y (gamma) effects on Macrophages
Macrophages secrete IL-12 --> NK cells secrete IFN-Y --> stimulate macrophages to kill phagocytosed pathogens
24
IFN-Y (gamma) effects on NK cells
Induces NK cells to kill virus infected cells
25
IFN-Y (gamma) effects on cells in general
Increase MHC expression and antigen presentation
26
IFN-Y gamma effects on T cells
Promotes Th1
27
IL-10 + TGF-beta
Decrease MHC class II expression and Th1 cytokines (attenuate immune response), inhibit activated macrophages and dendritic cells (secreted by Tregs)
28
IFN-alpha and beta
Innate host defense against viruses (glycoproteins synthesized by virus infected cells that act locally on un-infected cells, priming them for viral defense to selectively degrade viral nucleic acid protein)
29
Anti-Ach receptor
Myasthenia Gravis
30
