Everything Flashcards
(51 cards)
HLA A3
Hemochromatosis
HLA B27
Psoriatic Arthritis, Ankylosing spondylitis, arthritis of IBD, Reactive arthritis (PAIR - seronegative arthropathies)
DQ2/DQ8
Celiac disease
DR2
MS, hay fever, SLE, Goodpasture
DR3
DM1, SLE, Graves Disease, Hashimoto thyroiditis
DR4
Rheumatoid arthritis, DM1
DR5
Pernicious anemia (vitamin B12 def), Hashimoto thyroiditis
What cell has CD40R / what cell has CD40L
CD40 Receptor = B cell, CD40L = Th cell (B cell activation and class switching)
What cell has CD28, What cell has B7?
CD28 = Naive T cell, B7 = dendritic cell (Naive T cell activation)
C1 esterase inhibitor deficiency
hereditary angioedema (no ACEi!)
C3 deficiency
severe, recurrent pyogenic sinus/respiratory tract infections, increase susceptibility to T3HS rxns
C5-C9 deficiency
Susceptibility to recurrent Neisseria bacteremia
DAF (GPI anchored enzyme, CD55) deficiency
Complement mediated lysis of RBCs, paroxysmal nocturnal hemoglobinuria
IL-1 (osteoclast activating factor??)
Fever (HOT), activates endothelium to express adhesion molecules, induces chemokine secretion to attract WBCs
IL-2
stimulates T cells (Th, Tc, Treg, NK), can be secreted by T cells or macrophages
IL-3
stimulates Bone marrow stem cell growth and differentiation (like GM-CSF)
IL-4
stimulates IgE production, promotes Th2 differentiation, B cell growth
IL-5
stimulates IgA production, promotes differentiation of B cells, growth and differentiation of eosinophils
IL-6
Fever, stimulates production of acute phase reactants
IL-8
chemotactic factor for neutrophils (clean up on aisle 8!)
IL-12
induce differentiation of T cells into Th1, activate NK cells
TNF-alpha
Mediates septic shock, activates endothelium, WBC recruitment, vascular leak (cachexia in malignancy)
IFN-Y (gamma) effects on Macrophages
Macrophages secrete IL-12 –> NK cells secrete IFN-Y –> stimulate macrophages to kill phagocytosed pathogens
IFN-Y (gamma) effects on NK cells
Induces NK cells to kill virus infected cells
