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Things to memorize for Step 1 > Everything > Flashcards

Flashcards in Everything Deck (51)
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1

HLA A3

Hemochromatosis

2

HLA B27

Psoriatic Arthritis, Ankylosing spondylitis, arthritis of IBD, Reactive arthritis (PAIR - seronegative arthropathies)

3

DQ2/DQ8

Celiac disease

4

DR2

MS, hay fever, SLE, Goodpasture

5

DR3

DM1, SLE, Graves Disease, Hashimoto thyroiditis

6

DR4

Rheumatoid arthritis, DM1

7

DR5

Pernicious anemia (vitamin B12 def), Hashimoto thyroiditis

8

What cell has CD40R / what cell has CD40L

CD40 Receptor = B cell, CD40L = Th cell (B cell activation and class switching)

9

What cell has CD28, What cell has B7?

CD28 = Naive T cell, B7 = dendritic cell (Naive T cell activation)

10

C1 esterase inhibitor deficiency

hereditary angioedema (no ACEi!)

11

C3 deficiency

severe, recurrent pyogenic sinus/respiratory tract infections, increase susceptibility to T3HS rxns

12

C5-C9 deficiency

Susceptibility to recurrent Neisseria bacteremia

13

DAF (GPI anchored enzyme, CD55) deficiency

Complement mediated lysis of RBCs, paroxysmal nocturnal hemoglobinuria

14

IL-1 (osteoclast activating factor??)

Fever (HOT), activates endothelium to express adhesion molecules, induces chemokine secretion to attract WBCs

15

IL-2

stimulates T cells (Th, Tc, Treg, NK), can be secreted by T cells or macrophages

16

IL-3

stimulates Bone marrow stem cell growth and differentiation (like GM-CSF)

17

IL-4

stimulates IgE production, promotes Th2 differentiation, B cell growth

18

IL-5

stimulates IgA production, promotes differentiation of B cells, growth and differentiation of eosinophils

19

IL-6

Fever, stimulates production of acute phase reactants

20

IL-8

chemotactic factor for neutrophils (clean up on aisle 8!)

21

IL-12

induce differentiation of T cells into Th1, activate NK cells

22

TNF-alpha

Mediates septic shock, activates endothelium, WBC recruitment, vascular leak (cachexia in malignancy)

23

IFN-Y (gamma) effects on Macrophages

Macrophages secrete IL-12 --> NK cells secrete IFN-Y --> stimulate macrophages to kill phagocytosed pathogens

24

IFN-Y (gamma) effects on NK cells

Induces NK cells to kill virus infected cells

25

IFN-Y (gamma) effects on cells in general

Increase MHC expression and antigen presentation

26

IFN-Y gamma effects on T cells

Promotes Th1

27

IL-10 + TGF-beta

Decrease MHC class II expression and Th1 cytokines (attenuate immune response), inhibit activated macrophages and dendritic cells (secreted by Tregs)

28

IFN-alpha and beta

Innate host defense against viruses (glycoproteins synthesized by virus infected cells that act locally on un-infected cells, priming them for viral defense to selectively degrade viral nucleic acid protein)

29

Anti-Ach receptor

Myasthenia Gravis

30

Anti-basement membrane

Goodpasture