Ex. 2 L4: Noncompartmental Analysis Flashcards
Noncompartmental analysis
Do not look at compartments; just try to obtain information from the concentration vs time profile
Noncompartmental variables
AUC, AUMC, MRT, CL, Vdss
Clearance and compartmental analysis
Clearance for compartmental and noncompartmental are the same
Mean Residence time (MRT)
Drug X (MW = 300) 1 mg admin as IV bolus
of molecules in 1 mg:
0.001g/(300g/1 mole) * (6.023*10^23)molecules/1 mole =
2x10^18 molecules
MRT of drug X would mean the average time one drug molecule spends in the body from dosing to elimination
t * C is called
the first-moment of the concentration
AUMC
Area under the moment curve
MRT =
AUMC/AUC
ti =
the time ith molecule spends in the body
n =
Total number of molecules
When looking at a curve, always use (early/late) phase to estimate K
Late
After IV admin, AUC and AUMC can be
estimated regardless of peak shapes
MRT and CL can be estimated
Can we simplify two compartment to one compartment?
Major phase concept
What would be average drug concentration at steady state
Superstition principle
Major phase concept, 2 compartment model
A/alpha + B/Beta
Superstition principle
After multiple doses, AUCss,0-t = AUCsingle dose, 0-infinity
The last AUC is the sum of all of the other AUCs, = each other
