Ex 2. L2: Multi Dose II

Question 1

Dosing regimen steps

Answer 1

1. Know the target concentration range
2. Determine the max dosing interval (TauMax) round to reasonable interval (E.g., q6h, q8h, q12 and once daily)
3. Determine maintenance dose (DM). Choose Cssave to fall in the middle of target concentration range
4. Check whether Cssmax and Cssmin fall within the expected range. Adjust dosing regimen (dose or Tau) if they do not fall within the required range
5. If necessary, determine loading dose (DL)

Question 2

1: Know the target concentration range

Answer 2

We know that at conc. above 100mg/L Drug X shows signs of toxicity. We also know that at conc. Less than 20mg/L, drug shows no effect.
Range must be between 20-100

Question 3

2: Determine the max dosing interval (Tmax), round to reasonable interval

Answer 3

Max time interval over which the upper and lower concentrations can occur

Question 4

3. Determine Maintenance dose

Answer 4

(Dose/T)/CL * Tau * CL

Question 5

4. Check whether Cssmax and Cssmin fall within expected range

Answer 5

Make sure it is good as the concentration fluctuates within the therapeutic range window

Question 6

5. If necessary, determine loading dose

Answer 6

Time to reach SS

-Will reach ss after the second dose
-Loading dose is likely
unnecessary

Question 7

5. If you do not want to wait to reach therapeutic concentrations: Loading dose

Answer 7

DM = DL - DL * e^-Kt