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Flashcards in Exam 1 - ANS Deck (87):
1

the PNS is also known as the _____ system

PEACE, rest and digest

2

the SNS is also known as the _____ system

STRESS, fight/flight

3

what is the NT at all SNS and PNS PREganglionic neurons

ACh

4

what is the RECEPTOR on all SNS and PNS PREganglionic neurons

nicotinic

5

what is the NT at all POSTsynaptic neurons in the PNS

ACh

6

what NT are at the POSTsynaptic neurons in the SNS

norepinephrine and epinephrine

7

what are the RECEPTORS in the PNS

nicotinic and muscarinic

8

what are the RECEPTORS in the SNS

a1, a2, b1, b2, b3

9

receptors in the PNS are also known as ____ receptors

CHOLINERGIC

10

receptors in the SNS are also known as ____

adrenergic

11

effects of the PNS

rest and digest
1. pupils constrict
2. INC salivation
3. INC mucus production
4. INC peristalsis
5. INC bladder contraction (sphincter relaxes, urine prod INC)
6. blood shunts to GI to skeletal muscle

12

effects of SNS

fight/flight effects
1. dilation of pupils
2. DEC salivation
3. DEC mucus production
4. bronchodilation
5. INC HR
6. INC BP
7. glucogenolysis
8. DEC urine production (bladder relaxes and sphincter contracts)
9. cardiac and skeletal muscle contraction

13

cholinergic agonists have a ___ effect

INC PNS effect

14

cholinergic antagonists have a ___ effect

INC SNS effect

15

anti-cholinesterase have a ____ effect

INC PNS effect

16

adrenergic agonists have a _____ effect

INC SNS effect

17

adrenergic antagonists have a _____ effect

INC PNS effect

18

list the five adrenergic receptors

a1, a2, b1, b2, b3

19

where are the a1 adrenergic receptors located

eyes, BV

20

where are the a2 adrenergic receptors located

presynaptic junction

21

where are the b1 adrenergic receptors located

heart

22

where are the b2 adrenergic receptors located

lungs

23

where are the b3 adrenergic receptors located

detrusor muscle

24

MOA of anti-cholinesterase drugs

inhibit the enzyme that degrades ACh so they INC ACh at the synapse and have neuromuscular effects and activation of cholinergic receptors

25

2 non-clinical uses of anti-cholinesterase drugs

1. pesticides
2. nerve gas

26

list 3 anti-cholinesterase drugs

DEE
1. edrophonium
2. echothiophate
3. donepezil

27

edrophonium use

myasthenia gravis dx

28

echothiophate use

glaucoma therapy

29

donepezil use

alzheimers

30

list 7 clinical uses of muscarinic antagonists

1. opthamology
2. bradyarrythmias
3. motion sickness
4. COPD
5. peptic ulcer
6. antiparkinsonian
7. OAB

31

list 4 AE of muscarinic antagonists

1. dry mouth
2. blurred vision
3. constipation
4. urinary retention

32

list 4 muscarinic antagonist drugs

STAB
1. scopolamine
2. atropine
3. trihexphenidyl
4. benztropine

33

scopolamine use

motion sickness

34

atropine uses

bradyarrythmias, opthamology (pupil dilation)

35

2 antiparkinsonian drugs

triphenidyl, benztropine

36

nicotine stimulates nicotinic receptors in _____ and leads to release of

SNS and leads to release of epinephrine

37

CV effects of nicotine

INC HR and BP

38

partial agonist smoking cessation med

varenicline

39

MOA of botox

it is a cholinergic antagonist, it inhibits the release of ACh at NMJ which can lead to temporary paralysis

40

5 uses of botox

strabismus, axillary hyperhidrosis, prevention of migraine, OAB with neurological component, wrinkles

41

list 5 catecholamines/ simpathomimetics/ adrenergic agonists

1. norepinephrine
2. epinephrine
3. dopamine
4. isoprotenol
5. dobutamine

42

MOA of catecholamines

norepinephrine acts on adrenal medulla to release epinephrine into blood which stimulates more norepinephrine

43

only ____ works at dopamine receptor sites

dopamine

44

2 uses of epinephrine

anaphylaxis and glaucoma

45

2 catecholamine drugs to use for prolonged action of local anesthetics

epinephrine and norepinephrine

46

catecholamine drug used for shock

dopamine

47

agonists with B1 selectivity are for ___ and ____

hypoTN and cardiac stimulation

48

agonists with A1 selectivity are for _____

nasal decongestion

49

agonists with B3 selectivity are for _____

bladder relaxation

50

agonists with B2 selectivity are for ____

hypoTN

51

the only agonist for HTN is

clonidine/catapres, an A2 selective agonist

52

____ and ____ adrenergic ____ treat HTN

A1 and B1 adrenergic ANTAGONISTS treat HTN

53

A1 selective antagonists treat

BPH

54

MOA of beta blockers

adrenergic receptor blockers, catecholamines from receptors (BLOCK SNS response)

55

list the 5 cardiac uses of beta blockers

1. HTN
2. angina
3. MI
4. CHF
5. anti-arrhythmic

56

B1 selective drugs avoid blocking

b2 receptors on lungs

57

B2 receptors are important for the tx of

asthma

58

B1 partial agonists _____ less than newer more selective beta blockers

DEC HR

59

bethanechol use

urinary retention

60

pilocarpine use

glaucoma

61

three types of drugs for glaucoma

selective B1 antagonists
anticholinesterase
musacrinic agonists
(INC PNS)

62

an atypical antidepressant used for smoking cessation

bupropion

63

4 OAB drugs

DOTS
1. darifenacin (M3)
2. oxybutynin (M3)
3. tolterodine (M2/3 - non selective)
4. solifenacin (M3)

64

two types of neuromuscular blocking agents (anti-cholinergic competitive agonists)

non-depolarizing and depolarizing

65

non-depolarizing neuromuscular agents MOA

blocks nicotinic receptors at NMJ, no CNS effects (lasts 20-40 min)

66

clinical use of non-depolarizing neuromuscular agents

relaxation during surgery

67

two non-depolarizing neuromuscular agents

vercuronium, rocronium (20-40 min)

68

depolarizing neuromuscular agent MOA

partial agonist, persistent depolarization leads to muscle resistance to ACh stimulation (preferred, short acting 4-6 min)

69

clinical use of depolarizing neuromuscular agent

intubation

70

1 depolarizing neuromuscular drug

succinylcholine (4-6 min)

71

beta antagonist used for glaucoma

timolol

72

MOA of beta antagonists

blocks SNS, expect PNS

73

non selective beta 1 and 2 blocker

propanolol

74

selective b1 blockers (3)

BAM
1. atenolol
2. bisprolol
3. metoprolol

75

1 partial agonist beta blocker

acebutolol

76

2 non selective beta blockade

(CALALILLY - CL)
carvedilol
labetolol

77

alpha 1 antagonists treat ____ and ____

HTN and BPH

78

2 alpha 1 antagonist drugs for HTN

prazosin
terazosin

79

2 alpha 1 antagonist drugs for BPH

tamsulosin
finasteride

80

name the A1 selective agonist and what it treats

phenlyephrine for nasal decongestion

81

3 uses of A2 selective agonist and its name

CLONIDINE: HTN, migraine, opioid withdrawal

82

B2 selective agonists MOA

bronchodilation and uterine relaxation

83

B2 selective agonists uses and the drugs

asthma (albuterol), prevention of preterm labor (terbutaline)

84

B3 selective agonists use

OAB

85

MOA of muscarinic antagonists

block muscarinic receptors from picking up ACh, blocks PNS effects so expect SNS effects

86

list a b3 selective agonist drug used for OAB

mirabegron

87

pilocarpine MOA

contraction of iris sphincter that facilitates outflow of aqueous humor and DEC ICP