exam 1 hematology

Question 1

what makes up the hematologic system?

Answer 1

blood,spleen, BM, liver, thymus

Question 2

composition of blood

Answer 2

60-80ml/kg = 5L

Question 3

albumin

Answer 3

volume and osmotic pressure

Question 4

serum globulins

Answer 4

transport of lipid, bilirubin, immune functions

Question 5

fibrinogen

Answer 5

coagulation

Question 6

prothrombin

Answer 6

coagulation

Question 7

plasminogen

Answer 7

coagulation

Question 8

MCV

Answer 8

mean corpuscular volume
volume in each cell (size)

Question 9

MCH

Answer 9

mean corpuscular hgb
hgb in each cell (color)

Question 10

MCHC

Answer 10

mean corpuscular hgb concentration
hematocrit for each cell (shape)

Question 11

mild anemia

Answer 11

hb 10-14
may go w/o s
palpitations, external dyspnea, diaphoresis

Question 12

moderate anemia

Answer 12

hb 6-10
increased cardiopulmonary s
dyspnea

Question 13

severe anemia

Answer 13

hb <6
pallor, jaundice (increase serum bilirubin), pruritus, glossitis, blurred vision, tacky, mi,

Question 14

iron deficiency anemia causes

Answer 14

most common
blood loss GI/U, diet, malabsorption, hemolysis

Question 15

iron deficiency anemia s/sx

Answer 15

pallor, glossitis

Question 16

best way to absorb iron?

Answer 16

ferrous sulfate in acidic, no food

Question 17

megaloblastic anemia

Answer 17

group of disorders caused by impaired DNA synthesis
large RBCs

Question 18

types of megaloblastic anemia

Answer 18

cobalamin/ b12
folic acid

Question 19

pernicious anemia

Answer 19

absence of IF so cannot absorb b12

Question 20

aplastic anemia

Answer 20

decreased production of bone marrow elements

Question 21

hemolytic anemia

Answer 21

destruction or hemolysis of RBCs that exceeds production

Question 22

thalassemia

Answer 22

defective synthesis of hemoglobin
increased rigidity of erythricytes

Question 23

G-6-PD

Answer 23

defective synthesis of hemoglobin
essential for membrane stability

Question 24

anti sickling agent

Answer 24

hydroxyurea, erythropoietin, bone marrow transplant

Question 25

thrombocytopenia

Answer 25

decrease in circulating platelets, < 100,000

Question 26

thrombocytopenia s/sx

Answer 26

petechiae and purpura

Question 27

hemophilia A

Answer 27

deficiency in VIII
necessary for stabilization of fibrin clots

Question 28

hemophilia B

Answer 28

deficiency in factor IX
vitamin dependent beta globulin essential in stage 1 intrinsic coagulation

Question 29

von wile brand’s disease

Answer 29

deficiency of vWF, necessary for VIII activity and platelet adhesion

Question 30

disseminated intravascular coagulapathy

Answer 30

abnormal initiation of clotting and simultaneous hemorrhage

Question 31

hodgkins

Answer 31

peak 15-35
single lymph node and infiltrates the spleen, lung, liver

Question 32

non hodgkins

Answer 32

most common
50-70y
viral infection, immune, genetics
reed-sternberg absent
outside lymph and infiltrates