Exam 1: Intro to Clinical Toxicology Flashcards
1
Q
What is the NOEL? What is the NOAEL?
A
NOEL = 10mg/kg
NOAEL = 30mg/kg
2
Q
NOEL & NOAEL
A
3
Q
What is the LOEL? What is the LOAEL?
A
LOEL = 20mg/kg
LOAEL = 40mg/kg
4
Q
LOEL & LOAEL
A
5
Q
A
LOEL = 20/kg
LOAEL = 100g/kg
NOEL = 10g/kg
NOAEL = 60g/kg
6
Q
What is the equation for therapeutic index?
A
7
Q
What is the equation for the standard safety margin?
A
8
Q
A
TI = 50/10 = 5
MoS = 15/25 = 0.6
9
Q
Compare Acute v Chronic Exposure
A
Acute: exposure to one or multiple doses over a 24 hour period
Chronic: exposure for 3 months or longer
10
Q
A