Exam 1: Intro to Clinical Toxicology Flashcards

1
Q

What is the NOEL? What is the NOAEL?

A

NOEL = 10mg/kg
NOAEL = 30mg/kg

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2
Q

NOEL & NOAEL

A
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3
Q

What is the LOEL? What is the LOAEL?

A

LOEL = 20mg/kg
LOAEL = 40mg/kg

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4
Q

LOEL & LOAEL

A
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5
Q
A

LOEL = 20/kg
LOAEL = 100g/kg
NOEL = 10g/kg
NOAEL = 60g/kg

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6
Q

What is the equation for therapeutic index?

A
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7
Q

What is the equation for the standard safety margin?

A
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8
Q
A

TI = 50/10 = 5
MoS = 15/25 = 0.6

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9
Q

Compare Acute v Chronic Exposure

A

Acute: exposure to one or multiple doses over a 24 hour period
Chronic: exposure for 3 months or longer

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10
Q
A
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