Flashcards in Exam 1 Koh- Cornea Biochem 1 Deck (80)
Where are GAGs located?
Primarily on the surface of cells or in the ECM
What are the functions of GAGs?
High viscosity, low compressibility, rigidity provides structural integrity to cells (migration), negatively charged (hydration)
Because of their large number of negative charges, these heteropolysaccharide chains tend to be _____ in solution
What is the most abundant GAG in the body?
Chondroitin and 4 and 6 sulfates
Where is chondroitin and 4 and 6 sulfates found?
Cartilage, tendons, ligaments, and aorta
What do chondroitin and 4 and 6 sulfates form?
Proteoglycan aggregates often aggregating noncovalently with hyaluronic acid
What does chondriotin and 4 and 6 sulfates do in cartilage?
Bind collagen and hold fibers in a tight, strong network
What are the most heterogenous gylcosaminoglycans?
Keratan sulfates I and II
Where is keratan sulfate II found?
In loose CT proteoglycan aggregates with chondroitan sulfate
Where is Keratan sulfate I found?
What is the only GAG not limited to animal tissue but also found in bacteria?
What is hyaluronic acid serve as?
Lubricant and shock absorber
Where is hyaluronic acid found?
Synovial fluid of joints, vitreous humor of the eye, the umbilical cord, loose CT and cartilage
Where is dermatan sulfate found?
Skin, blood vessels, and heart valves
Alpha linkage joins what?
Unlike other GAGs that are ________ compounds, heparin is an ________ component of mast cells that line arteries especially in the liver, lungs and skin
What serves as an anticoagulant?
Where are glycosaminoglycans degraded?
What are the second most abundant corneal constituents?