Exam 1 Koh- Cornea Biochem 1 Flashcards Preview

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Flashcards in Exam 1 Koh- Cornea Biochem 1 Deck (80)
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61

Where are GAGs located?

Primarily on the surface of cells or in the ECM

62

What are the functions of GAGs?

High viscosity, low compressibility, rigidity provides structural integrity to cells (migration), negatively charged (hydration)

63

Because of their large number of negative charges, these heteropolysaccharide chains tend to be _____ in solution

Extended

64

What is the most abundant GAG in the body?

Chondroitin and 4 and 6 sulfates

65

Where is chondroitin and 4 and 6 sulfates found?

Cartilage, tendons, ligaments, and aorta

66

What do chondroitin and 4 and 6 sulfates form?

Proteoglycan aggregates often aggregating noncovalently with hyaluronic acid

67

What does chondriotin and 4 and 6 sulfates do in cartilage?

Bind collagen and hold fibers in a tight, strong network

68

What are the most heterogenous gylcosaminoglycans?

Keratan sulfates I and II

69

Where is keratan sulfate II found?

In loose CT proteoglycan aggregates with chondroitan sulfate

70

Where is Keratan sulfate I found?

In cornea

71

What is the only GAG not limited to animal tissue but also found in bacteria?

Hyaluronic acid

72

What is hyaluronic acid serve as?

Lubricant and shock absorber

73

Where is hyaluronic acid found?

Synovial fluid of joints, vitreous humor of the eye, the umbilical cord, loose CT and cartilage

74

Where is dermatan sulfate found?

Skin, blood vessels, and heart valves

75

Alpha linkage joins what?

Sugars

76

Unlike other GAGs that are ________ compounds, heparin is an ________ component of mast cells that line arteries especially in the liver, lungs and skin

Extracellular, Intracellular

77

What serves as an anticoagulant?

Heparin

78

Where are glycosaminoglycans degraded?

Lysosomes

79

What are the second most abundant corneal constituents?

Proteoglycans

80

What are the 3 major proteoglycans?

Lumican, keratocan, mimecan