Exam 1 Pcol 2 Flashcards

Question

Nalmefene | rev

Answer 1

Mu antagonist | Revex

Answer 2

Mu antagonist | vivitrol

Answer 3

Periphery Mu antagonist | relistor

Answer 4

periphery Mu antagonist | movantik

Answer 5

Periphery Mu antagonist | Symproic

Answer 6

Periphery Mu antagonist | Entereg

Answer 7

Kappa agonist/Mu antagonist | Nubian

Answer 8

Kappa agonist/Mu antagonist

Answer 9

Kappa agonist/Mu antagonist

Answer 10

Mu partial agonist / Kappa antagonist has hugh affinity to Mu receptors but very little intrinsic activity so less withdrawal symptoms | Subutex

Answer 11

Partial mu Agonist / Mu antagonist | Suboxone

Answer 12

Conotoxin peptide drug cause the closing of the N-type Ca2+ channels in the dorsal horn / spinal cord so no activation of the ascending neurons Can treat chronic pain | Prialt

Answer 13

Triptans Activate 5-HT 1B and 5-HT 1D | Imitrex

Answer 14

Triptan Activate 5-HT 1B and 5-HT 1D | Axert

Answer 15

Triptans Activate 5-HT 1B and 5-HT 1D | Zomig

Answer 16

Triptan Activate 5-HT 1B and 5-HT 1D | Amerge

Answer 17

Triptans Activates 5-HT 1B and 5-HT 1D | Maxalt

Answer 18

Triptan Activate 5-HT 1B and 5-HT 1D | Frova

Answer 19

Triptan activate 5-HT 1B and 5-HT 1D | Relpax

Answer 20

Ergots Activate 5-HT 1B , 5-HT 1D, can directly activate A1 receptors that are Gq, activate 5-HT 2a receptors in the uterus

Answer 21

Ergots Activate 5-HT 1B receptor in the blood vessles , 5-HT 1D receptor in the presynaptic, 5-HT 2a receptor in the uterus smooth muscle And directly activates A1 receptor

Answer 22

Ergot Activate 5-HT 2a receptor in the uterus and is use to stop post-partum bleeding | methergine

Answer 23

Ditans Activate 5-HT 1F and reduces the release of CGRP | Reyvow

Answer 24

Gepants CGRP Competitive antagonist | Ubrelvy

Answer 25

Gepans CGRP competitive antagonist | Nurtec ODT

Answer 26

Gepans CGRP competitive antagonist | Quilipta

Answer 27

Gepans CGRP competitive antagonist | Zavzpret

Answer 28

Monoclonal antibody CGRP antagonist

Answer 29

Monoclonal antibody CGRP antagonist

Answer 30

Monoclonal antibody CGRP antagonist

Answer 31

Monoclonal antibody CGRP antagonist

Answer 32

Sumatriptan (imitrex) + Naproxen (naprosyn)

Answer 33

Aspirin + Butalbital + Caffeine

Answer 34

Acetaminophen + Butalbital + Caffeine

Answer 35

Benzodiazepine Positive allosteric modulator enhances GABA by binding to the intercept between Y2 and A1 Short Acting Use for: -Anxiety provoking events -Produces brief sedation for short procedure and calms the pt -Use hypnotic effect--> Pt has trouble falling asleep | Versed

Answer 36

Benzo Positive allosteric modulation --> Enhances GABA Binds to the intercept between Y2 and A1 Use for: -Anxiety provoking events -Produces brief sedation for short procedure and calms the pt -Use hypnotic effect--> Pt has trouble falling asleep | Byfavo

Answer 37

Benzo = -am Positive allosteric modulator enhances GABA by binding to the intercept between Y2 and A1 Short acting Use for: -Anxiety provoking events -Produces brief sedation for short procedure and calms the pt -Use hypnotic effect--> Pt has trouble falling asleep | Halcion

Answer 38

Benzo --> Intermediate acting Postiive allosteric modulator binds in between the Y2 and A1 intercept and enhances GABA activity -Use for anxiety | Xanax

Answer 39

Benzo --> Intermediate acting Positive allosteric modulator enhances GABA by binding in between the Y2 and A1 intercept -Use for anxiety | Prosom

Answer 40

Benzo --> Intermediate acting Positive allosteric modulator --> bind in between the Y2 and A1 intercept and enhances GABA activity -Use for anxiety | Ativan

Answer 41

Benzodiazepine--> Intermediate acting Positive allosteric modulator it binds in between the Y2 and A1 intercept and enhances GABA -Use for anxiety | Serax

Answer 42

Benzodiazepine--> intermediate acting Positive allosteric modulator --> Binds in between the Y2 and A1 intercept and enhances GABA -Use for anxiety | Restoril

Answer 43

Benzodiazepine --> Intermediate acting Positive allosteric modulator binds in between the Y2 and A1 intercept enhacing GABA Use for anxiety | Rohypnol

Answer 44

Benzo--> Long acting Positive allosteric modulator binds in between the Y2 and A1 intercept and will enhance GABA Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | librium

Answer 45

Benzo --> Long acting Binds inbetween the A1 and Y2 intercept and enhances GABA is a positive allosteric Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Onfi

Answer 46

Benzo--> Long acting It binds inbetween the y2 and A1 intercept and enhances GABA activity is a positive allosteric modulation Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Klonopin

Answer 47

Benz--> Long acting Positive allosteric modulator binds next to the intercet of Y2 and A1 and enhances GABA activity Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Tranxene

Answer 48

Benzo --> Long acting Positive allosteric modulator binds in between the Y2 and A1 intercept and enhances GABA Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Valium

Answer 49

Long acting benzo Positive allosteric modulator --> Binds in between the Y2 and A1 intercept and enhances GABA activity Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Dalmane

Answer 50

Long acting Benzo Positive allosteric modulator binds in between the Y2 and A1 intercept and enhances GABA activity Use for: Anxiolytic Hypnotic--> Trouble maintaining sleep Myorelaxant Anticonvulsant | Doral

Answer 51

Benzodiazepine receptor antagonist It binds in between the Y2 and A1 intercept and prevent the benzodiazepines from binding -Has no effect on GABA

Answer 52

Z compound Is a positive allosteric modulator it binds to the GABA A receptor the one that has the A1 receptor that is found primarly in areas of the brain that produces Sedation and hypnotic effects | Ambien

Answer 53

Z-compound Positive Allosteric Modulator it binds to the GABA A receptor the one that has A1 receptor that is in areas of the brain that produces Sedation and Hypnotic effects | Sonata

Answer 54

Z compound Is a positive allosteric modulator it binds to the GABA A receptor the one that has the A1 receptor so is use because of its hypnotic effects | Lunesta

Answer 55

Ultra-Short acting barbiturate Positive allosteric modulator --> Binds to the GABA A receptor that has any A and B subunit and enhances GABA a inhibitor N.S It can also bind to AMPA receptor and block Glutamate from binding (Glutamate is a excitatory N.S) Use IV as pre-anesthesia

Answer 56

Ultra-short acting barbiturates Positive allosteric modulator --> Binds to GABA A receptor the ones that contain any A and B subunit and enhances GABA activity (inhibitory n.s) Cl- enter hyperpolarize the cell -It can also bind to AMPA receptors and block Glutamate from binding (a excitatory n.s) -Use for anesthesia in surgery

Answer 57

Short acting Barbiturate -Positive allosteric modulator --> Binds to GABA A receptor the ones that have A and B subunit and enhances GABA activity (inhibitory N.S and Cl- enter hyperpolarize the cell) -Can bind to AMPA receptors and block Glutamate from binding (excitatory n.s) -Use for physician assistant suicide | Seconal

Answer 58

Short acting Barbiturate Positive allosteric modulator--> Binds to GABA A receptor the ones that have any A and B subunit and enhances GABA activity (inhibitory n.s Cl- enters hyperpolarize the cell) -Can also bind to AMPA receptors and block Glutamate (excitatory n.s ) from binding -Use for pre-anesthesia -Was used for insonmnia | Nembutal

Answer 59

Intermediate Barbiturate -Positive allosteric modulator --> Binds to GABA A receptors the ones that have A and B subunit and enhaces GABA activity (a inhibitory n.s and Cl- enters hyperpolarize the cell) -Can also bind to AMPA receptors and will block Glutamate from binding -Use for sedating the pt -Was used for insomnia

Answer 60

Long acting Barbiturate -Positive allosteric modulator --> Binds to GABA A receptors the ones that have A and B subunit and enhances GABA activity (inhibitory n.s) -Can also bind to AMPA receptors and prevent glutamate from binding (excitatory n.s) -Use as anticonvulsant as a Na+ salt injection -Used to be use for insonmnia by PO | Luminal

Answer 61

MT1 and MT2 receptor agonist MT1 --> Associated with hypnotic effects MT2--> Associated with reset of the circadiam rhythm -Melatonin is produce endogenous by the pineal gland in the bran and follows the circadiam rhythm High during night Low during day

Answer 62

MT1 and MT2 agonist But is somewhat more selective for MT1 MT1 receptor is associated with Hypnotic effects Use Ramelteon (Rozerem) for insomnia | Rozerem

Answer 63

MT1/MT2 agonist Tasimelteon is more selective for MT2 receptor that is associated with reset of circadiam rhythm Is use to treat non-24 sleep wake disorder in a pt that is blind | Hetlioz

Answer 64

DORA's Dual Orexin Receptor Antagonist -Suvorexant (Belsomra) will block oxerin from binding to its receptor --> Therefore Oxerin won't be able to produce its wakefulness effects -Use for hypnotic --> Help pt fall asleep | Belsomra

Answer 65

DORA= Dual Orexin Receptor Antagonist Orexin is peptide in the brain that is associated with Wakefulness But Lemborexant (Dayvigo) will prevent orexin from binding -Use for Hypnotic effect--> Help pt fall asleep | Dayvigo

Answer 66

DORA's Dual Oxerin Receptor Antagonist Oxerin is peptide in the brain that is associated with wakefulness But Daridoxerant (Quviviq) will block oxerin from binding and produces hypnotic effect -Use to help pt fall asleep | Quviviq

Answer 67

5-HT1A Partial agonist It will activate 5-HT1A receptors that are in the pre-synaptic and will cause less release of 5-HT onto post synaptic 5-HT receptors (Serotonin causes anxiety) -By reducing the release of 5-HT from the presynaptic it causes Anxiolytic effects but it takes time weeks to develop the anxiolytic effects -Only use for chronic anxiety not for acute anxiety (event provoking anxiety) -Can also be use in pt that have substance abuse behavior and want to stay away from Benzodiazepines and Z drugs (Zola Zale Son Eszo Lunes) -Does not produce sedation and no hypnotic effects | Buspar

Answer 68

Centrally acting muscle relaxant works in the spinal cord -Work as a GABA B receptor agonist (GABA B is link to Gi) -Use for chronic muscle spasm -Can cause physical dependence so need to tapper down the dose because if the pt suddenly stop can suffer from withdrawals hallucinations | Lioresal

Answer 69

Is a Centrally Acting Muscle relaxant Is a A2 agonist Activates A2 receptors in the pre-synapse --> K+ Channels open K+ leaves and cause hyperpolarization --> Less release of glutamate Activates A2 receptors in the post-synapse motor neuron--> K+ channels open K+ leaves causes the motor neuron to be more negative and wont be able to generate impulses to the skeletal muscle | Zanaflex

Answer 70

Centrally acting muscle relaxant -Works by a indirect mechanism --> Inhibit the reuptake of Norepinephrine at the A2 receptors therefore indirectly causes increase activation of the A2 receptors in the presynaptic neuron --> So less release of glutamate In the postsynaptic--> K+ leaves so the post-synaptic motor neuron wont be able to generate impulses down to the skeletal muscle -Block Histamine H-1 receptors -Block Muscarinic receptors | Flexeril

Answer 71

Centrally acting muscle relaxant -Carisoprodol (Soma) is converted into is active metabolite that is Meprobamate Meprobamate will have similar effects like barbiturates --> Binds to the GABA A receptor and enhances GABA activity at the GABA A so Cl entry --> The post synaptic motor neuron is hyperpolarize and cannot generate impulses to the skeletal muscle -Use as muscle relaxant | Soma

Answer 72

Centrally acting Muscle relaxant -It blocks the NMDA receptor (A ligand gated receptor in the post synaptic motor neuron) and prevent Glutamate from binding so no Na+ entry --> The motor neuron won't be able to generate impulses to the skeletal muscle -Block Histamine-H1 receptors -Block Muscarinic receptors | Norflex

Answer 73

Centrally acting muscle relaxant It blocks NMDA receptors (Ligand gated) in the post-synaptic motor neuron so Block glutamate from binding so no Na+ entry --> No generation of impulses to the skeletal muscle -Block Histamine H1 receptors Block Muscarinic receptors | Robaxin

Answer 74

Direct acting muscle relaxant --> Does not work in the CNS it works directly in the Skeletal muscle -Inhibits the release of Ca2+ from the sarcoplasmic reticulum --> So no Ca2+ to work on the skeletal muscle --> No muscle contraction -Is also use as a antidote when someone uses succinylcholine and the pt has a genetic polymorphism and suffers from malignant hyperthermia | Dantrium

Exam 1 Pcol 2 Flashcards

(98 cards)