Exam 1 What is red in a lecture Flashcards
Lecture 1
What is the big idea of receptors?
Binding
High affinity (low amount of drug)
Low amount of drug
Slower ending of effect
Binding has an effect
If a drug is an agonist it activates the receptor
Lecture 1
What is the dissociation constant? (Kd)
Dissociation constant, measure of affinity/
potency. (Also is a ratio of the off rate of receptor binding to the on rate.)
Lecture 1
Heart: β agonists increase heart rate & force of contraction. How do they do it?
G-protein mediated signal transduction, a kinase activation
Lecture 1
Lungs: β agonists relax smooth muscle and dilate bronchioles instead of increasing contraction. How do they do it?
A kinase inhibition
Lecture 2
How do antagonists influence a graph of an agonist?
Bind & don’t activate receptor
Flat dose-response curve by themselves
Shift (to the right) the dose-response curve of an agonist
Lecture 2
True or false:
Some receptors may shift from active to inactive states without drugs
true
Lecture 2
When is ED50 lower than Kd?
When spare receptors are present…? Only need to activate a fraction of them to get maximal response
Lecture 3
Effect of a drug depends on…?
concentration
[Drug] = Drug (g)/Volume(l)
Lecture 3
What should you not give in an intravenous injection?
Don’t give oils, suspensions IV
Lecture 3
what is the importance of Apparent volume of distribution = Vd?
not only need to know g and mg but the volume as well to understand
where drug is going to be found and in what concentration has to be measured for you
Lecture 5
When does a drug maintain a steady state?
What should you know about dosing in a steady state?
After the drug reaches an equilibrium of uptake vs elimination it maintains a steady state concentration
Increases in dosing rate lead to a proportional increase in steady state plasma concentration
Lecture 6
name an acidic and basic drug
ampicillin and atropine
Lecture 6
What doe sp-glycoprotein remove and transport?
ivermectin and digoxin
Lecture 6
How much variation can happen?
a 9 fold
Lecture 7
true or false:
if the variability is large, even safe drugs become dangerous
true
