Exam

Question 1

How common is prostate cancer?

Answer 1

2nd most common in men

Question 2

In 2021 how many men were diagnosed with prostate cancer?

Answer 2

248,530

Question 3

Average age of prostate cancer diagnosis?

Answer 3

66

Question 4

Prostate cancer occurs most common in?

Answer 4

African Americans (2x more likely to develop)

Question 5

What are the zones of the prostate gland?

Answer 5

Anterior, Central, Peripheral, Transitional

Question 6

What is prostate cancer screening & what is involved?

Answer 6

PSA- (PSA Velocity-rate of change over time)- Prostate Specific Antogen
DRE- Digital rectal exam

Question 7

What is the normal level of PSA in a healthy man?

Answer 7

< 4ng/mL

Question 8

What is a prostate biopsy?

Answer 8

Taking samples of 12 cores throughout prostate gland to assign Gleason score and rating the cancer.

Question 9

T Categories? (staging)

Answer 9

T1-T2 are localized and locally advanced, T3-T4 are advanced disease (outside of the prostate capsule)

Question 10

TNM stands for and is used for?

Answer 10

Tumor, Nodes, Metastises- measures how far its spread?

Question 11

Active Surveillance is used when?

Answer 11

Cancer isn’t aggressive and has low risk of increasing in severity.

Question 12

Surgery is a common curative treatment when?

Answer 12

Prostate cancer is still within the capsule (confined to the prostate gland.)

Question 13

What are the major side effects of radical prostatectomy?

Answer 13

Urinary incontinence and E/D

Question 14

What type of treatment is Eligard and what does it do to the patient?

Answer 14

LhRh agonist that reduces Testosterone in the body, as well as testicular production of Testosterone.

Question 15

How many doses of Eligard are there and what are they?

Answer 15

7.5mg, 22.5mg, 30mg and 45mg

Question 16

How often is each dose injected?

Answer 16

7.5mg=monthly
22.5mg=every 3 months
30mg=every 4 months
45mg=every 6 months

Question 17

How much volume is injected with each dose?

Answer 17

7.5mg= .25mL
22.5mg= .375mL
30mg= .5mL
45mg= .375mL

Question 18

Where can Eligard be injected?

Answer 18

Avoid areas with brawny, or fibrous tissue, or that can be rubbed, or compressed (waistline.) Can be injected anywhere with sufficient subcutaneous tissue (buttocks, abdomen, thigh, or arm.)

Question 19

What are each dose of Eligard’s respective needle gauges and length?

Answer 19

7.5mg, 22.5mg and 30mg= 20 gauge and 5/8”
45mg=18 gauge and 5/8”

Question 20

What are the most common injection site AE’s in the Eligard clinical studies?

Answer 20

Transient burning and stinging, pain, erythema, bruising.

Question 21

How many patients from the clinical trials discontinued Eligard due to AE’s?

Answer 21

0

Question 22

The most frequently reported possibly systemic adverse event that occured in >2% was?

Answer 22

Hot flashes/sweats
Malaise and fatigue

Question 23

At what temperature should Eligard be stored?

Answer 23

2-8 degrees celsius

Question 24

After being brought to room temperature, how long is Eligard able to be used?

Answer 24

8 weeks

Question 25

How many doses of Lupron are there and what are they?

Answer 25

7.5mg, 22.5mg, 30mg and 45mg

Question 26

How often are Lupron's doses injected?

Answer 26

4 weeks, 12 weeks, 16 weeks and 24 weeks

Question 27

What timeframe must Lupron be injected in, once mixed?

Answer 27

2 hours

Question 28

What constitutes a tumor flare?

Answer 28

50% rise above baseline level of Testosterone, caused during initial 2-4 weeks of ADT.

Question 29

What temperature is Lupron stored?

Answer 29

25 degrees celsius.

Question 30

Why should Trelstar be administered immediated upon reconstituting?

Answer 30

To avoid separation of the suspension

Question 31

What are Trelstar's needle gauges and volume?

Answer 31

21 gauge and 2 mL for all doses

Question 32

Zoladex is administered how and where?

Answer 32

Subcutaneously in the anterior abdomen with aseptic (45 degree) technique.

Question 33

What are the approved doses of Zoladex and how often are they administered?

Answer 33

3.6mg every 28 days and 10.8mg every 12 weeks

Question 34

Is Firmagon an agonist, or antagonist? Explain the difference.

Answer 34

Firmagon is an antagonist. An agonist binds to the receptors and overloads it. The negative feedback loop tells the pituitary glad to stop producing. An antagonist binds to primary site and stops production (right at the pituitary gland.)

Question 35

What is the injection volume for each dose of Firmagon?

Answer 35

Loading dose of 2 3mL, then maintenance dose of 4mL monthlt.

Question 36

Out of 3 reported AE's for all products, which is the most common?

Answer 36

Hot flush/flushing

Question 37

What drug was Firmagon compared to in the active controlled study?

Answer 37

Leuprolide

Question 38

What type of delivery system is Orgovyx and what's the dosing?

Answer 38

Oral tablet. Loading dose of 360mg, with a daily maintenance dose of 120mg.

Question 39

If treatment with Orgovyx is interrupted for 7 days, or more what's required?

Answer 39

To restart the loading dose of 360mg.

Question 40

Camcevi is what molecule? How is it administered and dosed?

Answer 40

Camcevi is Leuprolide Mesolate. It's administered with a 45 degree angle subcutaneous injection in the abdomen. The only approved dose is 42mg for 6 months.

Question 41

What is Camcevi's needle gauge, length and volume?

Answer 41

18 gauge needle, 5/8" length with a .50mL

Question 42

What were the mean testosterone levels for each dose in the Eligard clinical studies?

Answer 42

7.5mg= 6.1ng/mL 22.5mg= 10.1ng/mL 30mg= 12.4ng/mL 45mg= 12.6 ng/mL