Exam 2

Question 1

James Murphy

Answer 1

(1911) observed that small lymphocytes likely responsible
for resistance to tuberculosis, cancer, and tissue transplant rejection.

Question 2

George Snell & Peter Gorer

Answer 2

(1946) genetically mapped Hantigens
and showed these were responsible for tissue
rejection

Question 3

Bruce Glick, Robert Goode, and Max Cooper

Answer 3

showed that T cells still develop in chickens lacking Bursa of
Fabricus but not in thymectomized chickens.

Question 4

Graham Mitchell & Jacque Miller

Answer 4

(1966) showed that bone
marrow cells could restore graft rejection in sublethally
irradiated mice, but not if mice were also thymectomized

Question 5

Lloyd Old & Edward Boyse

Answer 5

(1975) developed antibodies to
Lyt-2 antigen (CD8α) to permit isolation of T cells for use

Question 6

Kendall Smith

Answer 6

(1980) identified and cloned T cell growth factor gene
(interleukin 2) to permit growth of large numbers of T cells in laboratory
for use