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Flashcards in Exam 2 Deck (305)
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1

cox enzymes convert ___ into _____

convert aracadonic acid/ prostaglandin H2

2

what cofactor goes with alcohol dehydrogenase?

Zn2+

3

difunisal is

a cox inhibitor

4

frovatriptan is a

5-HT1 receptor agonist

5

what kind of enzyme is farnesyl diphosphate synthase?

transferase

6

farnesylated proteins are incorporated into proteins such as ____ and have effects on signaling through these

small GTPase proteins

7

EGFR complex with erlotinib is ___ inhibitor with respect to ATP

a competitive inhibitor

8

ketanserin is

a 5-HT2 antagonist

9

pamidrone is

a 2nd generation bisphosphonate

10

what enzyme do bisphosphynate drugs for the treatment of osteoporosis inhibit?

farnesyl diphosphate synthase

11

panitumumab is

an antibody to EGFR. Prevents EGFR signaling

12

PKC is

a serine/threonine kinase

13

for a noncompetitive inhibitor, Km

appears unaltered

14

Gefitinib is

a small molecule EGFR inhibitor

15

diltiazem is a _____ ______

benzothiazepine calcium channel blocker

16

alendronate is a ___ generation bisphosphonate

2nd

17

Cox __ inducible, primarily in __ during __

2/ macrophages/ inflammation

18

methyl salicylate is

a cox inhibitor

19

naratriptan is

a receptor 5-HT1 agonist

20

celecoxib is

a Cox inhibitor

21

a ________ is exposed in Cox-2, allowing for specificity

hydrophobic pocket

22

raloxifene is

an estrogen receptor antagonist

23

raloxifene is

a bisphosphonate

24

cetuximab is

an antibody to EGFR. prevents EGFR signaling

25

risedronate is ____ with respect to IPP

un-competitive

26

the NR3 subfamily includes the

steroid hormone receptors

27

mianserin is

a 5-HT2 antagonist

28

what cofactor goes with cytochromes?

Fe3+ or Fe2+

29

zolendronate is

a 3rd generation bisphosphonate

30

tamoxifen is

an estrogen receptor antagonist