Flashcards in Exam 2 Deck (93)
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1
What is the site of synthesis of Calcitonin including type of cells
"C" cells of the thyroid gland
2
Chemical class of calcitonin
PPP
3
2 primary functions of calcitonin
Decrease plasma calcium and decrease osteoclast cell synthesis and activity
4
3 secondary functions of calcitonin
Decrease digestion, plasma phosphorus, and plasma sodium
5
True of false calcitonin lowers phosphate in plasma
true
6
True or false calcitonin increases bone reabsorption
False, it inhibits it
7
Name two clinical uses for calcitonin
Osteoporosis and Paget's disease
8
What is osteoporosis
Bone mass and strength decreased
9
What is Paget's disease?
Disorder of the normal bone remodeling (example of old men talking about their hats not fitting because they're getting smarter)
10
True or false the bone that develops from Paget's disease is strong and normal
False, it is weak, abnormal and enlarged
11
What is the site of synthesis for Erythropoietin in adult
Kidney
12
What is the site of synthesis for Erythropoietin in a fetus
Liver
13
What is the chemical class of Erythropoietin
PPP
14
What is the function of Erythropoietin
Stimulate the development of RBC
15
Name 3 hormones that control the secretion of Erythropoietin
STH, Substance P, and Thyroxine
16
What is Erythropoietin EPO and what produces it
A hormone produced by the kidney
17
What does Erythropoietin EPO do?
promotes the formation of red blood cells by the bone marrow
18
What clinical treatment would Erythropoietin EPO be used for
Patients with amenia
19
What famous athlete used Erythropoietin EPO and why was it beneficial
Lance Armstrong, using the drug in a healthy body increases the RBC count and thus can increase an athletes VoMax
20
Name three things that can cause an increase in Erythropoietin
Performance enhancing drugs, heart attack or stroke, and thickening of the blood
21
True or false you would never prescribe Erythropoietin EPO to a patient with improperly functioning Kidneys
False, you WOULD prescribe Erythropoietin EPO (well...not you because you won't prescribe drugs)
22
Name the 2 sites of synthesis for Vitamin D
Liver and Kidney
23
Name the chemical class of vitamin D
Seco-steroid
24
What is the name of Vitamin D after hydroxylation in liver
25-hydroxcholecalciferol
25
What is the name of Vitamin D after hydroxylation in kidney
1, 25-Dihydroxycholecalciferol
26
What is the name of the form of Vitamin D in the kidney before it becomes hydroxylated again
1, 25-OH2D3
27
1-alpha-hydroxylase in the kidneys tightly regulates Vitamin D, what hormone controls 1-alpha-hydroxylase
Parathyroid hormone
28
What is the name of fully active form of vitamin D?
1, 25-Dihydroxycholecalciferol
29
Name the two primary functions of Vitamin D
Increase linear height, and increase plasma calcium
30
