Exam 2

Question 1

The rate limiting enzyme in the synthesis of catecholamines is

Answer 1

Tyrosine hydroxylase

Question 2

Which of the following most accurately represents the synthesis of catecholamines

Answer 2

Tyrosine dopa dopamine norepinephrine

Question 3

Catecholamines can be decreased by _____ which serves to ______

Answer 3

A-methyl-para-tyrosine / block tyrosine hydroxylate

Question 4

Once synthesis has occurred a protein called the ______ is responsible for packaging molecules of Dopamine into membrane packets for release

Answer 4

Vesicular monoamine transporter

Question 5

Activation of terminal autoreceptors inhibits dopamine release by

Answer 5

Decreasing Ca2+ entry into the terminal

Question 6

Which of the following about genetically engineered mice lacking the D2 autoreceptor is false

Answer 6

They had enhanced release of DA

Question 7

The first means of an activation of the catecholamines is

Answer 7

Reuptake by transporter proteins

Question 8

____ and ____ exert their pharmacological effects by blocking monoamine reuptake

Answer 8

Cocaine ; tricyclic antidepressants

Question 9

The two most important enzymes in the metabolism of monoamines are

Answer 9

Catechol-o-methyltransterase and monoamine oxidase

Question 10

Dopemenergic cell bodies in the vta send projections to the nucleus accumbens and the amygdala via the ______ dopamine pathway

Answer 10

Mesolithic

Question 11

The dopamine pathway most important for regulating movement is the ____ pathway

Answer 11

Nigrostriatal

Question 12

The major difference between D1 and D 2 dopamine receptor subtypes is that one

Answer 12

Inhibits and one stimulates adenylyl clyclase and CAMP

Question 13

Dopamine transporter knockout mice are hyperactive relative to wild type mice because

Answer 13

The dopaminergic neurons cannot remove dopamine from the synaptic cleft

Question 14

Which of the following isn’t a catecholamine

Answer 14

Glutamine

Question 15

The most prevalent mechanism for removing catecholamines from the synaptic cleft is

Answer 15

Presynaptic reuptake by membrane-bound transporter proteins

Question 16

6- hydroxydopamine (6-OHDA) is a(n) _______ used to _______

Answer 16

Neurotoxin ; damage catecholamine

Question 17

The ______ dopamine pathway has been implicated as an important mechanism contributing to drug abuse

Answer 17

Mesolimbic

Question 18

Dopaminergic cell bodies are found primarily in the ______ while adrenergic cell bodies are found in the ______

Answer 18

Midbrain ; pons and medulla

Question 19

The main location of the Noradrenergic cell bodies in the CNS is the

Answer 19

Locus coeruleus

Question 20

Like dopamine receptors, all norepinephrine receptors are

Answer 20

Metabotropic

Question 21

In the passive avoidance learning paradigm, learning is demonstrated by

Answer 21

Increase latency to enter the dark compartment

Question 22

The treatment of generalized anxiety with b-receptor antagonist is effective because beta blockers

Answer 22

Reduce sympathetic automatic nervous system activity thereby reducing some of the physical symptoms associated with anxiety