Exam 2 Flashcards
(22 cards)
The rate limiting enzyme in the synthesis of catecholamines is
Tyrosine hydroxylase
Which of the following most accurately represents the synthesis of catecholamines
Tyrosine dopa dopamine norepinephrine
Catecholamines can be decreased by _____ which serves to ______
A-methyl-para-tyrosine / block tyrosine hydroxylate
Once synthesis has occurred a protein called the ______ is responsible for packaging molecules of Dopamine into membrane packets for release
Vesicular monoamine transporter
Activation of terminal autoreceptors inhibits dopamine release by
Decreasing Ca2+ entry into the terminal
Which of the following about genetically engineered mice lacking the D2 autoreceptor is false
They had enhanced release of DA
The first means of an activation of the catecholamines is
Reuptake by transporter proteins
____ and ____ exert their pharmacological effects by blocking monoamine reuptake
Cocaine ; tricyclic antidepressants
The two most important enzymes in the metabolism of monoamines are
Catechol-o-methyltransterase and monoamine oxidase
Dopemenergic cell bodies in the vta send projections to the nucleus accumbens and the amygdala via the ______ dopamine pathway
Mesolithic
The dopamine pathway most important for regulating movement is the ____ pathway
Nigrostriatal
The major difference between D1 and D 2 dopamine receptor subtypes is that one
Inhibits and one stimulates adenylyl clyclase and CAMP
Dopamine transporter knockout mice are hyperactive relative to wild type mice because
The dopaminergic neurons cannot remove dopamine from the synaptic cleft
Which of the following isn’t a catecholamine
Glutamine
The most prevalent mechanism for removing catecholamines from the synaptic cleft is
Presynaptic reuptake by membrane-bound transporter proteins
6- hydroxydopamine (6-OHDA) is a(n) _______ used to _______
Neurotoxin ; damage catecholamine
The ______ dopamine pathway has been implicated as an important mechanism contributing to drug abuse
Mesolimbic
Dopaminergic cell bodies are found primarily in the ______ while adrenergic cell bodies are found in the ______
Midbrain ; pons and medulla
The main location of the Noradrenergic cell bodies in the CNS is the
Locus coeruleus
Like dopamine receptors, all norepinephrine receptors are
Metabotropic
In the passive avoidance learning paradigm, learning is demonstrated by
Increase latency to enter the dark compartment
The treatment of generalized anxiety with b-receptor antagonist is effective because beta blockers
Reduce sympathetic automatic nervous system activity thereby reducing some of the physical symptoms associated with anxiety
