Exam 2- Chapter 6 Flashcards Preview

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Flashcards in Exam 2- Chapter 6 Deck (57)
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1

B cells are kept in (SMALL/LARGE) amounts

Small

2

Source of B cells

Bone marrow stem cells

3

Phase 1 of B Cell development

B cell precursors acquire antigen receptors and go through rearrangement

4

Phase 2 of B cell development

Negative selection

5

Phase 3 of B cell development

Positive selection

6

Phase 4 of B cell development

B cells patrol for pathogens

7

Phase 5 for B cell development

B cell activation (results in proliferation and colonial expansion)

8

Phase 6 of B cell development

B cell differentiation (results in production of effector cells and memory cells)

9

Pluripotent hematopoietic stem cells give rise to:

B / T cells

10

B cell precursors

Pro-B cells

11

What type of gene rearrangement takes place with Pro-B cells?

Heavy chain gene rearrangement

12

What type of B cells undergo light chain gene rearrangements?

Pre-B cells

13

What happens when gene rearrangements are completed?

Pre-B cell becomes an immature B cell

14

Receptor types on a pluripotent hematopoietic stem cell

CD34

15

Receptor types on a common lymphoid progenitor

CD34 and CD10

16

Receptor types on a B cell precursor

CD34
CD10
And CD127

17

Receptor types on a pro-B cell

CD34
CD10
CD127
And CD19

18

Cells that assist with B cell maturation- act as the parents

Stromal cells

19

How long to stromal cells help B cells mature?

Until they are mature enough to leave the bone marrow.

20

How do stromal cells interact with B cells?

Through adhesion molecules

21

What growth factor does the stromal cell produce to help B cell mature?

IL-7

22

Where do B cells travel to after they leave the bone marrow?

Secondary lymphoid organs (lymph nodes, spleen, peyer’s patches)

23

Pro-B cells have to rearrange themselves into:

Productive rearrangement (antibody)

24

If the pro-B cell has an incorrect arrangement, it is called:

What happens if it cannot get to productive?

Non-productive arrangement

Will undergo apoptosis and die

25

Percentage of cells that survive heavy chain rearrangement

50%

26

B cells have ___#___ functional immunoglobulin

1

27

What happens after the first functional immunoglobulin is completed?

Rearrangement and transcription is halted to prevent formation of additional immunoglobulins

28

Choosing one allele over another:

Allelic exclusion

29

Allelic exclusion gives homogenous B-Cell receptors only with”

High avidity binding (single specificity)

30

Percent of B cells that have a successful light chain rearrangement

85%