Flashcards in Exam 2- Chapter 6 Deck (57)
B cells are kept in (SMALL/LARGE) amounts
Source of B cells
Bone marrow stem cells
Phase 1 of B Cell development
B cell precursors acquire antigen receptors and go through rearrangement
Phase 2 of B cell development
Phase 3 of B cell development
Phase 4 of B cell development
B cells patrol for pathogens
Phase 5 for B cell development
B cell activation (results in proliferation and colonial expansion)
Phase 6 of B cell development
B cell differentiation (results in production of effector cells and memory cells)
Pluripotent hematopoietic stem cells give rise to:
B / T cells
B cell precursors
What type of gene rearrangement takes place with Pro-B cells?
Heavy chain gene rearrangement
What type of B cells undergo light chain gene rearrangements?
What happens when gene rearrangements are completed?
Pre-B cell becomes an immature B cell
Receptor types on a pluripotent hematopoietic stem cell
Receptor types on a common lymphoid progenitor
CD34 and CD10
Receptor types on a B cell precursor
Receptor types on a pro-B cell
Cells that assist with B cell maturation- act as the parents
How long to stromal cells help B cells mature?
Until they are mature enough to leave the bone marrow.
How do stromal cells interact with B cells?
Through adhesion molecules
What growth factor does the stromal cell produce to help B cell mature?
Where do B cells travel to after they leave the bone marrow?
Secondary lymphoid organs (lymph nodes, spleen, peyer’s patches)
Pro-B cells have to rearrange themselves into:
Productive rearrangement (antibody)
If the pro-B cell has an incorrect arrangement, it is called:
What happens if it cannot get to productive?
Will undergo apoptosis and die
Percentage of cells that survive heavy chain rearrangement
B cells have ___#___ functional immunoglobulin
What happens after the first functional immunoglobulin is completed?
Rearrangement and transcription is halted to prevent formation of additional immunoglobulins
Choosing one allele over another:
Allelic exclusion gives homogenous B-Cell receptors only with”
High avidity binding (single specificity)