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PHA 430 - Immunopharmacology and Biotechnology > Exam 2 - Cytokines (part 2) > Flashcards

Exam 2 - Cytokines (part 2) Flashcards

(60 cards)

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1
Q

What does CSF stand for?

A

Colony Stimulating Factors

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2
Q

T/F: Colony Stimulating Factors are a family of glycoproteins.

A

TRUE

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3
Q

Colony stimulating factors support _____ colony formation.

A

Colony stimulating factors support HEMATOPOIETIC colony formation.

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4
Q

Name the cytokines that stimulate hematopoiesis.

A

COLONY STIMULATING FACTORS (CSFs)

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5
Q

What are colony stimulating factors also known as?

A

Blood-forming cytokines

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6
Q

T/F: Colony stimulating factors support the survival, proliferation, and maturation of Hematopoietic Progenitor Cells.

A

TRUE

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7
Q

What function do CSFs modulate?

A

CSFs modulate the function of MATURE EFFECTOR CELLS

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8
Q

T/F: CSFs include only lineage specific cytokines.

A

FALSE

-CSFs include both lineage specific and multipotential cytokines

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9
Q

What term describes cytokines that only acts on one type of cell?

A

Lineage specific

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10
Q

What term describes cytokines that act on more than one type of cell through proliferation, maturation, etc.?

A

Multipotential

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11
Q

T/F: CSFs protect patients from infection and allow increase in cytotoxic agents.

A

TRUE

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12
Q

CSFs prevent ______ - ______ neutropenia.

A

CSFs prevent CHEMOTHERAPY-INDUCED neutropenia.

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13
Q

When do CSFs stimulate heamopoiesis?

A

In BONE MARROW FAILURE

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14
Q

CSFs promote cell _____.

A

CSFs promote cell DIFFERENTIATION.

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15
Q

Do CSFs assist in marrow transplantation?

A

YES

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16
Q

What is effector cell function?

A

What a cell does

-CSFs augment effector cell function

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17
Q

T/F: CSFs stimulate monocyte’s anticancer effects.

A

TRUE

-Increase tumor killing ability of monocytes

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18
Q

What does G-CSF stand for?

A

Granulocyte-CSF (colony stimulating factor)

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19
Q

What secretes G-CSF?

A

Macrophages, Endothelium, and Leukocytes

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20
Q

What does ADCC stand for?

A

Antibody Dependent Cell-mediated Cytotoxicity

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21
Q

One function of IgG is ____.

A

One function of IgG is ADCC.

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22
Q

G-CSF is considered a ____ ____ cytokine.

A

G-CSF is considered a LINEAGE SPECIFIC cytokine.

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23
Q

What does G-CSF stimulate?

A

NEUTROPHILS ONLY

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24
Q

T/F: Granulocyte-CSF is responsible for the survival of eosinophils.

A

FALSE

-Granulocyte-CSF is responsible for the survival of NEUTROPHILS

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25
G-CSF stimulates ____ ____ to produce neutrophils and then direct their migration to the peripheral blood.
G-CSF stimulates BONE MARROW to produce neutrophils and then direct their migration to the peripheral blood.
26
What is a growth factor for the proliferation, differentiation, effector function, and survival of neutrophils?
G-CSF
27
T/F: G-CSF causes proliferation of endothelial cells.
TRUE
28
T/F: G-CSF decreases the phagocytic activity of neutrophils.
FALSE | -G-CSF enhances the phagocytic activity of neutrophils
29
Does G-CSF cause ADCC?
YES | -It causes antibody-mediated cellular toxicity by neutrophils
30
Name the drug that is a G-CSF.
Filgrastim
31
What type of cytokine is Filgrastim?
G-CSF
32
How is Filgrastim produced?
By recombinant DNA technology
33
Who receives Filgrastim?
Pts receiving cytotoxic chemotherapy for advanced cancer
34
What does Filgrastim cause in terms of neutropenia?
A dose-dependent amelioration of neutropenia associated with cancer-chemotherapy.
35
Filgrastim has been well tolerated and may reduce the ____ and ____ rate associated with chemotherapy.
Filgrastim has been well tolerated and may reduce the MORBIDITY and MORTALITY rate associated with chemotherapy.
36
What does Filigrastim do to cytotoxic agents?
It permits the used of high doses of cytotoxic agents and a greater anti-tumor response
37
What is the name of the drug that stabilizes neutrophils?
Filgrastim
38
What does GM-CSF stand for?
G - Granulocyte | M - Macrophage
39
What does granulocyte mean?
NEUTROPHILS
40
What cell types produce GM-CSF?
Macrophages, T cells | -Also: mast cells, fibroblasts, endothelial cells
41
What does GM-CSF do?
It stimulates stem cells to produce neutrophils and monocytes -Monocytes migrate into tissues and differentiate into macrophages
42
T/F: GM-CSF cytokines are multilineage cytokines.
TRUE
43
What type of cytokine is Sargramostim?
GM-CSF
44
What kind of side effects does Sargramostim exhibit?
Flu-like symptoms
45
T/F: Sargramostim is a human recombinant GM-CSF.
TRUE
46
When does Sargramostin exhibit beneficial effects?
On bone marrow function in pts getting high dose chemo in the setting of autologous bone marrow transplantation as well as in the treatment of advanced cancers
47
What disease states has Sargramostim been used for to stimulate bone marrow function?
- AIDS - Myelodysplastic Syndrome - Aplastic Anemia
48
What do high doses of Sargramostim result in?
- Weight gain - Generalized edema - Hypotension
49
GM-CSF causes _____ -_____ asymptomatic eosinophilia.
GM-CSF causes DOSE-DEPENDENT asymptomatic eosinophilia.
50
What produces IL-11?
BONE MARROW STROMA
51
What does IL-11 activate?
- B cells - Plasmacytomas - Hepatocytes - Megakaryocytes
52
IL-11 plays a role in ____ ____ proliferation and increases ____ levels after chemo.
IL-11 plays a role in BONE CELL proliferation and increases PLATELET levels after chemo.
53
T/F: IL-11 does not modulate antigen-antibody responses.
FALSE | -IL-11 does modulate antigen-antibody responses
54
What cell types does IL-11 promote differentiation in ?
- Progenitor B cells | - Megakaryotes
55
Name the drug that is an Interleukin-11 drug.
Oprelvekin (Neumega)
56
____ is recombinant human IL-11.
OPRELVEKIN is recombinant human IL-11.
57
What is Oprelvekin used for?
To stimulate bone marrow to induce PLT production in pts on chemo
58
When Oprelvekin administered?
SC | 6-24 hours after chemo
59
What side effects does Oprelvekin have?
- Flu-like - Fluid retention - Tachycardia - Edema - N/V - SOB
60
What is Oprelvekin used to treat?
PLT deficiency (cancer, genetic abnormality)

PHA 430 - Immunopharmacology and Biotechnology (9 decks)

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