Exam 2 GI Inf Flashcards
(27 cards)
Most common GI Inf in developed countries
1) Camplyobacter
2) Salmonella
3) Shigella
1 GI in underdeveloped countries
Cholera
Campylobacter
EXOGENOUS
NEGATIVE SPIRAL ROD
#1 Diarrhea in developed (USA)
40% Guillermo barre + for campylobacter.
Source: CHX (Normal chx flora), unpasteurized milk, contaminated water
Tans: consume improper cooked
Results : Gastroenteritis
Dysentery stool with blood
E. Coli 0157
EHEC-
NEGATIVE, EXOGENOUS
Source: Cattle normal flora, undercooked beef,
Trans: hand/mouth, fecal/oral, consumption
Results: Hemorrhagic colitis, kidney damage
LOW ID50
Salmonella Enteritidis
EXOGENOUS, gram negative
ID50>1000
Source: chx, egg, mayo
Trans: consumption, room temp
Results:GASTROENTERITIS
Shigella
S. Dysentry- bacillary dysentry
EXOGENOUS
Most common diarrhea dz
Source: fecal/oral, daycare
Trans: Hand/Mouth
Results: GASTROENTERITIS
ID50<200
WW
sanitation & water chlorination
Staph Areus
ENDOGENOUS
Produces enterotoxin
Source: food contamination, potatoe salad
Trans: room temp ^^^ toxins
Results: INTOXICATION
Exogenous organisms are all NEGATIVE except:
Staph Aureus + Cocci
Clostridium difficile + Bacillus
Endogenous are all + EXCEPT
Coil forms (ECOLI)
Endogenous organisms
Streptococcus +
Enterococcus +
Coliforms (e. Coli) -
Clostridium +
ALL CAUSE DIVERTICULITIS, APPENDIX ABCESS, HEPATOBILIARY SEPSIS,
Exogenous organisms
Contaminated food/water
Hospital environment (c. Diff)
Oral/oral, oral/fecal - H.Pylori
Nausea vomiting w/i 6 hrs
Travelers Diarrhea
Intoxication
ETEC - Enterotoxigenic or EAEC- Enteroaggretive
Improperly cooked food
Food Poisoning
Intoxication vs infection
Intoxication: 2-8 hrs, severity:depends on amount of toxin
Infection:L 12 hrs-days
Severity: pathogen virulence ID50
Nosocomial INF
E.COLI
C.DIFF
Hospital employees & contaminated food
Streptococcus mutants
Biofilm dental caries , dental abcess
ETEC- Enterotoxigenic ecoli
TRAVELERS DIARRHEA
FECAL/ORAL
Toxin: heat liable&stabile
ENTEROTOXIGENIC
WATERY DIARRHEA
Hypersecreation
EPEC -ENTEROPATHOGENIC ECOLI
FECAL/ORAL
ENTEROPATHOGENIC
WATERY DYSENTRY
Covering of small intestine
EIEC- ENTEROINVASIVE ECOLI
INVADE FOOD
ENTEROINVASIVE
Severe diarrhea 12-70 hours
DYSENTRY
Invasion/.inflammation
EHEC- ENTEROHEMORRAHGIC
ENTEROHEMORRAHGIC
LOW ID50
SHIGA TOXIN
FECAL/ORAL & CATTLE
BLOODY DIARRHEA
EAEC- enteroaggretative
Travelers diarrhea #2
Mucoid watery diarrhea
Salmonella Infections
Gastroenteritis- stomach & intestines, improper food handle
Bacteremia- acute gastroenteritis->septic shock, pathogens->meninges,bones,site of malignancy
Enteric fever- sustained bacteremia, profound inf of organs, LN,Liver,spleen
Chronic inf- bilary tract,serious in blood, myocarditis, intravascular coag encephalopathy
Typhoid- salmonella enterica typhoid, bact in gallbladder
Fecal/oral- survive in macrophages, Peters patch>necrotic
Salmonella tx’s
All treated with fluids and electrolyte replacement
NO ABX- increase duration I & frequency of carrier state. —Only prophylactic
Vaccine available
Clean water and treat carriers
Vibrio Intoxication
Gram negative, facultative anaerobe
Low tolerance for acidic
Produce devastating toxin
COMMA SHAPED
RICE WATER DIARRHEA
NO FEVER OR BLOOD IN STOOL
TX- fluid replacement , tetracycline shortens diarrhea
Helicobacter Pylori
LPS
More toxic than other gram -
TLR-4
Generate ammonia - survive in acidic environment b/c UREASE
Stomach ulcers. POLAR
Pesto bismol
