Exam 3: Cancer Pharmacology Flashcards Preview

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Flashcards in Exam 3: Cancer Pharmacology Deck (14):
1

"Guardian of the genome":

P53 tumor suppressor gene

2

Two-hit hypothesis:

Both alleles for tumor suppressor gene must mutate for gene to lose function

3

MoA of methotrexate:

Prevents reduction of FH2 to FH4, interfering with DNA synthesis

4

MoA of doxorubicin:

Inhibits topoisomerase II, which relaxes the DNA coil, thus interfering with DNA replication

5

MoA of cyclophosphamide:

Attach alkyl groups to guanines, causing guanines on the helix to link and "stick" DNA in its coil, interfering with DNA replication

6

MoA of vincristine:

Binds to microtubules, preventing their polymerization and arresting the cell in metaphase

7

MoA of tamoxifen:

Antagonizes estrogen at the receptor level

8

Two ways monoclonal antibodies work:

Block growth signals
Stop new blood vessels from forming

9

MoA of cetuximab:

Binds to mutated growth factor receptor and prevents its downstream signalling

10

MoA of bevacizumab/Avastin:

Inhibits vascular endothelial growth factor A, thus blocking angiogenesis

11

MoA of tyrosine kinase inhibitors:

Prevent the phosphorylation of the tyrosine kinase, which prevents the signaling cascade that leads to cell proliferation

12

Define BCR-Abl:

Philadelphia chromosome
Chromosome 22 translocates with chromosome 9

13

BCR-Abl associated with this cancer:

CML

14

Example of a tyrosine kinase inhibitor:

Gleevec (imantinib)