Exam 3- Diabetic Meds Flashcards Preview

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Flashcards in Exam 3- Diabetic Meds Deck (47)
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1

Metformin/Glucophage

Biguanides

2

Chlorpropamide/Diabinese

Sulfonylurea (1st gen)

3

Tolbutamide/Orinase

Sulfonylurea (1st gen)

4

Glipizide/Glucotrol

Sulfonylurea (2nd gen)

5

Glyburide/Micronase, Diabeta

Sulfonylurea (2nd gen)

6

Glimepiride/Amaryl

Sulfonylurea (2nd gen)

7

Nateglinide/Starlix

Meglitinides

8

Repaglinide/Prandin

Meglitinides

9

Rosiglitazone/Avandia

Thiazolidinediones (Glitazones)

10

Pioglitazone/ACTOS

Thiazolidinediones (Glitazones)

11

Troglitazone/Rezulin

Thiazolidinediones (Glitazones) (LETHAL SE)

12

Acarbose/Precose

Alpha-glucosidase inhibitors

13

Miglitol/Glyset

Alpha-glucosidase inhibitors

14

Sitagliptin/Januvia

Dipeptidyl peptidase-4 (DPP-4) inhibitors

15

Pramlinitide/Smylin

Aylin Agonist Analog (Injectable)

16

Exenatide/Byetta

Incretin mimetics (Injectable)

17

#1 Dec liver production of glucose #2 increase insulin sensitivity in the periphery

Biguanide (Metformin/Glucophage)

18

Increase insulin production in the pancreas (secretagogues); bind ATP sensitive K+ channels in beta cells = inc insulin release

Sulfonylurea (Glipizide/Glucotrol); Meglitinides (Nateglinide/Starlix)

19

dec peripheral insulin resistance in skeletal m., fat cells, and liver cells by affecting gene expression of PPAR gamma #2 dec liver production of glucose

Thiazolidinediones (TZDs) / Glitazones (Rosiglitazone/Avandia)

20

Interferes with carbohydrate absorption at the GI Brush border

Alpha-glucosidase inhibitors (Acarbose/Precose)

21

Diminish the inactivation of GLP-1 and GIP, which serves to increase the secretion of insulin and suppress release of glucagon.

Dipeptidyl peptidase-4 (DPP-4) inhibitors

22

Slow gastric emptying and suppress glucagon production

Aylin agonist analogs (Pramlintide/Symlin)

23

Enhance glucose-dependent insulin secretion and suppress increased glucagon secretion and also slow gastric emptying (mimics Glucagon-like peptide 1)

Incretin mimetics (Exenatide/Byetta)

24

Do not give to people with sulfa allergies

Sulfonylureas: Chlorpropamide/Diabinese, Tolbutamide/Orinase, Glipizide/Glucotrol, Glyburide/Micronase, Diabeta, Glimepiride/Amaryl

25

B12 def

Biguanide (Metformin/Glucophage)

26

Lactic acidosis, esp in ppl with renal impairment

Biguanide (Metformin/Glucophage)

27

weight loss

Biguanide (Metformin/Glucophage)

28

weight gain

Sulfonylureas (Glipizide/Glucotrol)

29

Ineffective after 5-10 years

Sulfonylureas (Glipizide/Glucotrol)

30

Med induced hypoglycemia

Sulfonylureas (Glipizide/Glucotrol) and Meglitinides (Nateglinide/Starlix)

31

Do not use with Sulfonylureas

Meglitinides (Nateglinide/Starlix)

32

Rapid absorption, rapid clearance

Meglitinides (Nateglinide/Starlix)

33

Takes 6-14 wks for full effects

Glitazones (TZDs) (Rosiglitazone/Avandia)

34

CHF

Glitazones (TZDs) (Rosiglitazone/Avandia)

35

Only ACTOS with insulin

Glitazones (TZDs) (Rosiglitazone/Avandia)

36

Liver function tests

Glitazones (TZDs) (Rosiglitazone/Avandia)

37

Inc bone fractures

Glitazones (TZDs) (Rosiglitazone/Avandia)

38

Fatal hepatic failure (rare)

Alpha-Glucosidase Inhibitors (Acarbose/precose)

39

If hypoglycemia, use glucose not sucrose

Alpha-Glucosidase Inhibitors (Acarbose/precose)

40

C/I with intestinal dz

Alpha-Glucosidase Inhibitors (Acarbose/precose)

41

Inc risk for pancreatitis

Dipeptidyl peptidase-4 (DPP-4) Inhibitors (Sitagliptin/Januvia)

42

Ok with Metformin, TZDs, Sulfonylureas but NO INSULIN

Dipeptidyl peptidase-4 (DPP-4) Inhibitors (Sitagliptin/Januvia)

43

First approved injectable since insulin

Aylin Agonist Analogs (Pramlintide/Symlin)

44

Synthetic version of amylin (produced with insulin in beta cells)

Aylin Agonist Analogs (Pramlintide/Symlin)

45

Synthetic exendin-4

Incretin mimetics (Exenatide/Byetta)

46

Gila monster spit

Incretin mimetics (Exenatide/Byetta)

47

Used for both Types 1 and 2 DM

Incretin mimetics (Exenatide/Byetta); Aylin Agonist Analogs (Pramlintide/Symlin)