EXAM 3 - Neurocognitive Disorders Flashcards

1
Q

Neurocognitive Disorders

A

Affect learning, memory, and consciousness

Most develop later in life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Types of neurocognitive disorders

A

Delirium
Major or mild neurocognitive disorder
Amnestic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Delirium

A

– temporary confusion and disorientation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Major or mild neurocognitive disorder

A

– broad cognitive deterioration affecting multiple domains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amnestic

A

Amnestic – refers to problems with memory that may occur in neurocognitive disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

delirium

A

Central features – impaired consciousness and cognition
Develops rapidly over several hours or days
Appear confused, disoriented, and inattentive
Marked memory and language deficits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DSM5 criteria for Delirium

A

A. Disturbance in attention (i.e., reduced ability to direct, focus, sustain, and shift attention) and awareness (reduced orientation to the environment).
Patient will be able to see and acknowledge you however they will not be able to sustain the attention
B. The disturbance develops over a short period of time (usually hours to a few days), represents an acute change from baseline attention and awareness, and tends to fluctuate in severity during the course of a day.
Patient will have an abrupt change in cognition from baseline and symptoms will be fluctuating. Patient will go in and out of a state of confusion. Sundowning.
C. An additional disturbance in cognition (e.g. memory deficit, disorientation, language, visuospatial ability, or perception).
Patient has difficulty with attention and is accompanied by an additional disturbance in cognition.
Very Low Mini Mental Score
D. The disturbances in Criteria A and C are not better explained by a pre-existing, established or evolving neurocognitive disorder and do not occur in the context of a severely reduced level of arousal such as coma.
Not a progression of a pre-existing dementia (dementia predisposes) , remember acute.
Patient has to be able to respond to verbal stimulation.
E. There is evidence from the history, physical examination or laboratory findings that the disturbance is a direct physiological consequence of another medical condition, substance intoxication or withdrawal (i.e. due to a drug of abuse or to a medication), or exposure to a toxin, or is due to multiple etiologies.
There is always a medical reason for delirium, trick is to find it.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Delirium Facts and statistics

A

Affects up 20% of adults in acute care facilities (e.g., ER)
More prevalent in certain populations, including:
Older adults
Those undergoing medical procedures
AIDS patients and cancer patients
Full recovery often occurs within several weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Medical Conditions Related to Delirium

A

Medical conditions
Dementia (50% of cases involve temporary delirium)
Drug intoxication, poisons, withdrawal from drugs
Infections
Head injury and several forms of brain trauma
Sleep deprivation, immobility, and excessive stress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Delirium Treatment

A

Attention to precipitating medical problems
Psychosocial interventions
Reassurance/comfort, coping strategies, inclusion of patients in treatment decisions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Delirium Prevention

A

Address proper medical care for illnesses, proper use and adherence to therapeutic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Nature of dementia

A

Gradual deterioration of brain functioning
Deterioration in judgment and memory
Deterioration in language / advanced cognitive processes
Has many causes and may be irreversible
Individual is able to function independently with some accommodations (e.g., reminders/lists)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

DSM5 criteria for MAJOR dementia

A

pic - NOT POSSIBLE TO LIVE INDEPENDENTLY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

DSM5 criteria for MILD dementia

A

pic - POSSIBLE TO LIVE INDEPENDENTLY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

DSM-5 Types of Major and Mild Neurocognitive Disorder

A
Due to Alzheimers Disease
Frontotemporal
Vascular
With Lewy bodies
Due to traumatic brain injury
Substance/medication induced
Due to HIV infection
Due to prion disease
Due to Parkinson’s Disease
Due to Huntington’s disease
Due to another medical condition
Due to multiple etiologies
Unspecified
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Causes of Neurocognitive Disorder: The Example of Alzheimer’s Disease

A

Features of brains with Alzheimer’s disease
Neurofibrillary tangles (strandlike filaments)
Amyloid plaques (gummy deposits between neurons)
Brains of Alzheimer’s patients tend to atrophy

Example of Hugh and Burt, identical twins

17
Q

Cause of Alzheimer’s Disease : GENETIC

A

Multiple genes are involved in Alzheimer’s disease
Include genes on chromosomes 21, 19, 14, 12
Chromosome 14
Associated with early onset Alzheimer’s
Chromosome 19
Associated with late onset Alzheimer’s

18
Q

Medical Treatment of Neurocognitive Disorders

A

Few primary treatments exist
Most treatments attempt to slow progression of deterioration, but cannot stop it
Future directions
Glial cell-derived neurotrophic factor, stem cells: may slow deterioration
Some drugs target cognitive deficits
Cholinesterase-inhibitors: Aricept, Exelon, Reminyl
Long-term effects not well demonstrated