Exam 3 - Nutrition and Metabolism Flashcards

(40 cards)

1
Q

Nutrition

A

The process by which the body obtains and uses certain components of food. The process includes:
1) Digestion
2) Absorption
3) Transportation
4) Cell metabolism

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2
Q

Nutrients

A

Substances taken into the body that are used by the cells of the body to produce energy, to provide building blocks for new molecules, and to function in other chemical reactions. Divided into six major classes:
1) Carbohydrates
2) Lipids
3) Proteins
4) Vitamins
5) Minerals
6) Water

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3
Q

Essential nutrients

A

Indispensable nutrients
Substances that must be ingested because the body cannot manufacture them at all or cannot manufacture adequate amounts of them. Include:
1) Certain amino acids and fatty acids
2) Most vitamins
3) Minerals
4) Water
5) A few carbohydrates

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4
Q

Kilocarloies

A

1000 calories
Used to express the larger amounts of energy supplied by foods and released through metabolism
Amount of energy (heat) necessary to raise the temperature of 1000g of water 1 degree C

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5
Q

MyPlate

A

A food icon to replace the former food icon, myPyramid
MyPlate is a simple visual reminder of how to build a healthful meal
Shows a plate and glass with portions representing foods from fruits, vegetables, grains, proteins, and dairy food groups

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6
Q

Dietary sources of carbohydrates

A

Most come from plants, with the exception of lactose. Complex carbohydrates: Whole grains, legumes, vegetables, fruits
Simple carbohydrates: Table sugar, honey, candy, fruit juices

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7
Q

Carbohydrate uses in body

A

1) Energy production: Carbohydrates are broken down into glucose, which fuels all body cells, especially the brain, muscles, and red blood cells
2) Glycogen storage:
Disaccharides and polysaccharides are converted to glucose, or stored as glycogen, which is a short-term energy-storage molecule that the body can store in liver and muscles in limited amounts
3) Sparing protein: Carbohydrates prevent body from breaking down muscle protein for energy
4) Digestive health: Dietary fiber, a type of carbohydrate, promotes healthy digestion and helps regulate sugar

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8
Q

Daily recommended amounts of carbohydrates in diet

A

General recommendations: 45-65% of daily calories
Fiber recommendations: 25g/day for women and 38g/day for men

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9
Q

Types of carbohydrates

A

1) Monosaccharides: Glucose, fructose, galactose
2) Disaccharides: Sucrose, maltose, lactose
3) Polysaccharides (complex): Starch, glycogen, cellulose; Cellulose is indigestible
Disaccharides and polysaccharides are converted to glucose

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10
Q

Types of lipids and their dietary sources

A

1) Triglycerides: Used for energy or stored; 95%; Includes saturated fats, like meat fats, whole milk, cheese, and eggs, and unsaturated fats, like olive and peanut oil
2) Cholesterol: Steroid found in liver, egg yolks, but not found in plants
3) Phospholipids: Major components of plasma membranes
4) Linoleic acids: Essential fatty acids. Found in seeds, nuts, legumes, grains, and green leaves

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11
Q

Uses of lipids in the body

A

Triglycerides: Produce ATP. Excess stored in adipose tissue or liver
Cholesterol: Ingested or made in body. Used in plasma membranes, bile salts, and steroids
Eicosanoids: Derived from fatty acids. Used for inflammation, blood clotting, tissue repair, smooth muscle contraction
Phospholipids: Used in plasma membrane, myeline sheath, bile

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12
Q

Dietary sources of protein

A

Chains of amino acids. Two types:
1) Essential: Must be obtained in a diet
2) Nonessential: Body can synthesize
Complete proteins: Contain all necessary amino acids, like meat, fish, poultry, milk, cheese, and eggs

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13
Q

Uses of protein in the body

A

1) Protection: Antibodies
2) Regulation: Enzymes and hormones
3) Structure: Collagen
4) Muscle contraction: Actin and myosin
5) Transportation: Hemoglobin and ion channels

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14
Q

Metabolism

A

Total of all the chemical reactions that occur in the body. Consists of catabolism and anabolism

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15
Q

Catabolism

A

Includes the energy-releasing process by which large molecules are broken down into smaller molecules
Hormones: Glucagon, epinephrine, cortisol

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16
Q

Anabolism

A

Includes the energy-requiring process by which small molecules are joined to form larger molecules
Hormones: Testosterone, growth hormone, IGF-1, insulin

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17
Q

Glycolysis

A

Beginning of carbohydrate metabolism
Series of chemical reactions that result in the breakdown of glucose into two pyruvate molecules
Four phases:
1) Input of ATP: Two ATP used in phosphorylation, where phosphate group is transferred from ATP to glucose
2) Sugar cleavage
3) NADH production:
4) ATP and pyruvate production: One glucose produces four ATP molecules, two NADH, and two pyruvate molecules. Final yield of each glucose molecules is two ATP, two NADH, and two pyruvate molecules

18
Q

Citric acid cycle

A

Two acetyl-CoA molecules enter the citric acid cycle, which produces four CO2, six NADH, two FADH2, and two ATP

19
Q

Electron-Transport chain

A

Uses NADH and FADH2 to produce 28 ATP. Process requires O2, which combines with H+ to form H2O

20
Q

Aerobic respiration process

A

Glycolysis
Citric acid
Electron-transport chain
Each glucose molecule produces a net gain of 32 ATP molecules: 2 from glycolysis, 2 from citric acid cycle, and 28 from electron-transport chain

21
Q

Lipid metabolism

A

Triglycerides are broken down into glycerol and fatty acids. Glycerol enters glycolysis to produce ATP. Fatty acids are broken down by beta-oxidation into acetyl-CoA, which enters the citric acid cycle to produce ATP and electron carriers. Acetyl-CoA can also be used to produce ketone bodies. Glucose is converted to glycerol, and amino acids are converted to acetyl-CoA molecules. Acetyl-CoA molecules can combine to form fatty acids. Glycerol and fatty acids join to form triglycerides

22
Q

Absorptive metabolic state

A

Absorptive: Period immediately after a meal, when nutrients are being absorbed through the intestinal wall into the circulatory and lymphatic systems. Usually lasts about 4 hours after each meal. Cells use most of the glucose that enters the body for energy they require. Remainder is converted into glycogen or lipids. Most absorbed lipids are deposited in adipose tissue. Many absorbed amino acids are used by cells for protein synthesis or energy. Secretion stimulated by increased blood glucose, increased blood amino acids, and the hormones, gastrin, CCK, and secretin. Food in gut

23
Q

Minerals

A

Inorganic and necessary for normal metabolic functions
Functions: Establish resting membrane potentials, generate action potentials, add strength to bones and teeth, buffers, involved in osmotic balance, are components of coenzymes, vitamins, and hemoglobin
Obtained from animal and plant sources

24
Q

Vitamins

A

Provitamins: Organic molecules in minute quantities of food. Can be conerted to functioning vitamins
Classifications:
1) Lipid-soluble: A, D, E, K. Can be stored in fatty tissues
2) Water-soluble: B, C, and all others. Remain short time then are excreted
Function: Coenzymes combine with enzymes and make the enzyme functional

25
Developmental aspects
Lack of proteins during fetal growth to 3 years of age: Metabolic problems in kids, even without genetic issues (except diabetes mellitus I)Agents prescribed for age-related medical problems that influence nutrition
26
Agents prescribed for age-related medical problems that influence nutrition
1) Diuretics: For heart failure. Can lead to hypokalemia, or low K+ in the blood 2) Antibiotics: Inhibit digestion/absorption 3) Mineral oil: Interference with fat solute vitamin absorption 4) Excess alcohol consumption: Malabsorption, deranged metabolism, vitamin deficiency, liver and pancreas damage
27
Nutrient timing
Suzuki 1999: Fed CHO mix immediately post-exercise, which led to 70% increased fat oxidation enzyme and 24% decreased abdominal fat, vs. 4 hour delay, which resulted in no change over months Esmarck 2001: Fed CHO/protein mix immediately, which led to muscle increased by 8% and strength increased by 15%, vs. 2 hour delay, which resulted in no change over months
28
Insulin effects
1) Sedentary individual with high carb diet: Insulin stimulates fat storage 2) Strength athlete can harness effect if timed correctly Stimulate: Protein synthesis, amino acid transport, glucose uptake, muscle glycogen storage, muscle blood flow Inhibit: Protein degradation and cortisol release
29
Oxerin
Self stimulating hormone Produced in hypothalamus Plays a role in regulating wakefulness and arousal, appetite and energy homeostasis, and reward systems Increases hunger/appetite enhancement
30
2 sets of hypothalamus neurons
Regulation of food intake 1) LHA neurons promote hunger when stimulated by neuropeptides 2) VMN neurons cause satiety through release of CRH when stimulated by appetite-suppressing peptides
31
Postabsorptive metabolic state
Postabsorptive: Occurs after absorptive state has concluded. Blood glucose levels are maintained by conversion of other molecules to glucose. As glycogen stores are depleted, the body uses lipids as an energy source. Amino acids can be converted to glucose as well. Major metabolic thrust; Catabolism and replacing food in blood
32
Amino acid metabolism
1) Transamination: Amine group is switched from amino acid to keto acid 2) Oxidative deamination: The amine group of glutamic acid is removed as ammonia and combined with CO2 to form urea 3) Keto acid modification: Keto acids formed during transamination are altered so they an easily enter Krebs cycle pathways This happens when: 1) Excess protein in diet; Amino acids cannot be stored 2) Too low kcal intake; Break down muscle when fat is gone
33
Non-dietary factors affecting cholesterol
Low density levels increased by smoking, stress, coffee High density levels increased by aerobic exercise and estrogen
34
Body shape correlates with cholesterol levels
1) Apple: Excess weight on upper body; Correlated with higher cholesterol and LDL levels 2) Pear: Excess weight on hips and thighs; Correlated with lower cholesterol and LDL levels
35
Cholesterol
Structural basis of bile salts, steroid hormones, and vitamin D Transport HDL from tissues to liver Transport LDL to tissues for use and determines regulation for how much cholesterol is needed VLDL transport triglycerides to tissues for use
36
Why liver produces cholesterol
At basal level, regardless of dietary intake In response to saturated fatty acids
37
Saturated fatty acids
Stimulate liver synthesis of cholesterol Inhibit cholesterol excretion from body
38
Unsaturated fatty acids
Enhance excretion of cholesterol
39
Transverse fats
Increase LDLs and reduce HDLs
40
Unsaturated Omega-3 Fatty acids
In cold-water fish Lower proportions of saturated fats and cholesterol Have anti-arrhythmic effects on heart Help prevent spontaneous clotthing Lower blood pressure