Exam 3 - Ott (MS) Flashcards
Route of Admin? Interferon B1a (Avonex)
IM once weekly
Route of Admin? Interferon B1a (Rebif)
SQ 3 x week
Route of Admin? Interferon B1b (Betaseron, Extavia)
SQ QOD
Route of Admin? Peginterferon B1a (Plegridy)
SQ q 14 days
needs titration!!
Route of Admin?
Glatiramer (Copaxone)
SQ QD
Route of Admin?
Fingolimod (Gilenya)
PO QD
Route of Admin?
Teriflunomide
PO QD
Route of Admin? Dimethyl Fumarate (Tecfidera)
PO BID
Route of Admin?
Natalizumab
IV q 4 weeks
Route of Admin?
Mitoxantrone
IV q 3 mos
Route of Admin?
Alemtuzumab
IV infusion over 4 hours
1st course x 5 days
2nd course x3 days (given 1 yr after first course)
Route of Admin?
Daclizumab
SQ once monthly
Route of Admin?
Ocrelizumab
IV at least 3.5 hours q 6 months
which MS drug should be premedicated with corticosteroids
alemtuzumab (lemtrada) done for 1st days of each course
also…
ocrelizumab
which MS drug is Pregnancy X/Contraindicated in pregnancy
Teriflunomide (Aubagio)
which MS drugs are given IM
interferon B1a (Avonex)
which MS drugs are given SQ
Interferon B1a (Rebif) Interferon B1b (Betaseron, Extavia) Peginterferon B1a (Plegridy) Glatiramer Acetate (Copaxone) Daclizumab (Zinbryta)
which MS drugs are given orally
Fingolimd (Gilenya)
Teriflunomide (Aubagio)
Dimethyl Fumarate (Tecfidera)
which MS drugs are given IV
Natalizumab (Tysabri)
Mitoxantrone (Novantrone)
Alemtuzumab (Lemtrada)
Ocrelizumab (Ocrevus)
which drug has AV block as a risk
Fingolimod (Gilenya)
what is measured in MS drug clinical trials to measure impact/efficacy
EDSS - expanded disability status scale
EDSS:
what would 0 mean? and what would 10 mean?
0 = normal neurological examiniation 10 = death from MS
in RRMS, progression ot SPMS is about _____ years
20 - 25
what type of MS typically starts in pts over 50 y.o
PPMS (primary progressive)