Exam 3 Set 1 2017 Flashcards
(42 cards)
The antigens that provoke hypersensitivity reactions are referred to as:
A. T-independent antigens B. Superantigens C. Subunit vaccines D. Attenuated vaccines E. Allergens
E. Allergens
Which of the following is matched incorrectly?
A. Type I hypersensitivity: IgE
B. Type II hypersensitivity: IgG
C. Type III hypersensitivity: immune complexes
D. Type IV hypersensitivity: IgG
E. Type IV hypersensitivity: delayed-type hypersensitivity
D. Type IV hypersensitivity: IgG
Which of the following is associated with insoluble antigen?
A. Type I hypersensitivity B. Type II hypersensitivity C. Type III hypersensitivity D. Type IV hypersensitivity E. Mast-cell activation
B. Type II hypersensitivity
An example of type III hypersensitivity is:
A. Contact dermatitis B. Asthma C. Serum sickness D. Tuberculin reaction E. Allergic rhinitis
C. Serum sickness
A reaction to poison ivy is associated with:
A. Mast-cell activation B. An Arthus reaction C. Eosinophil activation D. Complement activation E. Cytotoxic T-cell activation
E. Cytotoxic T-cell activation
Which of the following distinguishes IgE from the other antibody isotypes?
A. IgE binds to Fc receptors on NK cells
B. IgE binds to Fcε receptors in the absence of antigen
C. IgE is found in mucosal secretions
D. IgE binds to matrix-associated antigens
B. IgE binds to Fcε receptors in the absence of antigen
Which cells express FcεRI and contain granules containing inflammatory mediators? (Select. all that apply)
A. Macrophages B. Activated eosinophils C. Mast cells D. Natural killer cells E. Basophils
B. Activated eosinophils
C. Mast cells
E. Basophils
Inhaled allergens possess which of the following features that promote the priming of TH2 cells that drive IgE responses?
A. They are not proteins B. They are processed into peptides that bind HLA class I C. Many are proteases D. They are encountered at high dose E. They are of high molecular weight
C. Many are proteases
The wheal and flare inflammatory reaction is an example of
A. An immediate type I allergic response
B. A late-phase type I allergic response
C. A late-phase type IV allergic response
D. An immediate type III allergic response
E. A late-phase type III allergic response
A. An immediate type I allergic response
Which reaction occurs 6-8 hours after an initial type I allergic response in which mast cells produce leukotrienes, chemokines and cytokines?
A. Arthus reaction B. Late-phase reaction C. Delayed-type hypersensitivity reaction D. Condition known as anaphylactic shock E. Skin rash known as chronic urticaria
B. Late-phase reaction
Which of the following tests is used to determine whether a particular allergen is responsible for asthma?
A. Measure wheal and flare diameter after intradermal injection of allergen
B. Measure of Arthus reaction diameter after intradermal injection of allergen
C. Inject a controlled amount of allergen intradermally and observe urticaria
D. Measure peak expiratory flow rate (PEFR) after inhalation of allergen
E. Measure eosinophils in nasal secretions after inhalation of allergen
C. Inject a controlled amount of allergen intradermally and observe urticaria
Systemic anaphylaxis is caused by the presence of allergen in ______.
A. The gastrointestinal tract B. The respiratory tract C. The circulation D. The skin E. Mismatched blood transfusions
C. The circulation
During the course of a successful desensitization process, the patient’s antibodies will change from an _______ isotype to an ______ isotype
A. IgG; IgE B. IgE; IgM C. IgA; IgM D. IgG; IgM E. IgE; IgG
E. IgE; IgG
What type of hypersensitivity reaction would result from a mismatched blood transfusion?
A. Type I B. Type II C. Type III D. Type IV E. Type V
B. Type II
Which of the following is associated with a type III hypersensitivity reaction?
A. Allergen binding to cell-surface components and creating foreign epitopes
B. Cross-linking of IgE on mast cells
C. Formation of small immune complexes that are deposited in blood vessel walls
D. Inhibition of complement fixation
E. Antibody excess
C. Formation of small immune complexes that are deposited in blood vessel walls
Which of the following can induce a type III hypersensitivity reaction?
A. Pentadecacatechol of poison ivy B. Dust mite feces C. Therapeutic monoclonal antibodies D. Tuberculin E. Immediate reactions
C. Therapeutic monoclonal antibodies
Which of the following can induce a type IV hypersensitivity reaction?
A. Penicillin B. Dust mite feces C. Therapeutic monoclonal antibodies D. Tuberculin E. Mold spores
D. Tuberculin
Which of the following is associated with an immune response towards poison ivy?
A. Immediate reactions B. Highly reactive lipid-like molecule forms covalent bonds with host proteins C. Immune complexes with pentadecatechol D. Mast-cell degranulation E. Activation of Th2 cells
B. Highly reactive lipid-like molecule forms covalent bonds with host proteins
Which of the following is characterized by intestinal atrophy, HLA-DQ2 or DQ8 gluten-derived peptide complexes and anti-transglutaminase autoantibodies?
A. Type I hypersensitivity to food allergens B. Celiac disease C. Contact sensitivity D. Hypereosinophilia E. Eczema
B. Celiac disease
Which one of the following mast cell products is NOT preformed and therefore has to be newly synthesized?
A. Histamine B. Prostaglandins C. Heparin D. Neutral protease E. Eosinophil chemotactic factor (ECF)
B. Prostaglandins
Which type of hypersensitivity cannot be transferred with serum antibody?
A. Type I
B. Type II
C. Type III
D. Type IV
D. Type IV
Anaphylaxis can be triggered by cross-linking of IgE receptors on:
A. Monocytes B. Mast cells C. B-cells D. Eosinophils E. Neutrophils
B. Mast cells
Type IV hypersensitivity is often referred to as:
A. Immediate B. Delayed C. Anaphylactic D. Anergic E. Allotypic
B. Delayed
The major effector molecules involved in type IV hypersensitivity reactions are:
A. Antibodies B. Complement components C. Cytokines D. Prostaglandins E. 5-hydroxytryptamine (5-HT)
C. Cytokines
