Exam 3 - Thrombosis Flashcards Preview

Pharmacotherapeutics III > Exam 3 - Thrombosis > Flashcards

Flashcards in Exam 3 - Thrombosis Deck (31):
1

VTE treatment - UFH regular IV dosing

80 U/kg IV bolus followed by 18 U/kg/hr iV infusion

2

VTE treatment - UFH regular subQ dosing

initial dose of 333 U/kg subQ, followed by 250 U/kg subQ q12hrs

3

UFH renal adjustments

None

4

Is monitoring required for both IV and subQ UFH treatment?

No, only required for IV treatment

5

monitoring parameters for UFH IV treatment

aPTT 6 hrs after bolus and each dose adjustment OR anti-Xa activity for pts with excess factor VII or large doses

6

target range for aPTT

1.5-2.5x the normal value

7

VTE treatment - enoxaparin regular dosing

1 mg/kg subQ q12hrs OR 1.5 mg/kg subQ q24hrs

8

VTE treatment -
enoxaparin renal adjustments

For CrCl < 30 mL/min, 1 mg/kg q24hrs subQ

9

monitoring parameters for enoxaparin

anti-Xa activity for pregnant pts, burn pts, severe renal impairment, pts with extreme weights (< 50 kg/> 190 kg), prolonged therapy

10

VTE treatment - dalteparin regular dosing

100 U/kg subQ q12hrs OR 200 U/kg subQ q24hrs

11

dalteparin renal adjustments

None

12

What is the regular dosing for fondaparinux in VTE treatment?

< 50 kg = 5 mg subQ q24hrs
50-100 kg = 7.5 mg subQ q24hrs
> 100 kg = 10 mg subQ q24hrs

13

What renal adjustments are required with fondaparinux treatment?

CI for CrCl < 30 mL/min

14

What monitoring parameter are required for fondaparinux treatment?

anti-Xa activity

15

What is the regular dosing for apixaban in VTE treatment?

10 mg PO q12hrs for 7 days, followed by 5 mg PO q12hrs

16

What are the renal adjustments required with apixaban treatment?

CI for CrCl < 25 mL/min

17

What is the regular dosing for rivaroxaban in VTE treatment?

15 mg PO q12hrs for 21 days, followed by 20 mg PO q24hrs

18

What are the renal adjustments required with rivaroxaban treatment?

CI for CrCl < 30 mL/min

19

What is the regular dosing for edoxaban in VTE treatment?

60 mg PO daily OR 30 mg PO daily for pts less than or equal to 60 kg

20

What are the renal adjustments required with edoxaban treatment?

CI for CrCl < 15 mL/min

21

What is the regular dosing for dabigatran in VTE treatment?

150 mg PO q12hrs

22

What are the renal adjustments required with dabigatran treatment?

CI for CrCl < 30 mL/min

23

What are the oral therapies that cannot be started right away and the parameters needed prior to administration?

edoxaban and dabigatran cannot administered until 5-10 days of parental anticoagulation therapy is received

24

What is the brand name of enoxaparin?

Lovenox

25

What is the brand name of dalteparin?

Fragmin

26

What is the brand name of fondaparinux?

Arixtra

27

What is the brand name of apixaban?

Eliquis

28

What is the brand name of rivaroxaban?

Xarelto

29

What is the brand name of edoxaban?

Savaysa

30

What is the brand name of betrixaban?

Bevyxxa

31

What is the brand name of dabigatran?

Pradaxa