Exam 3: Vasodilators & Tx of Angina Pectoris Flashcards
(24 cards)
Most common CV disease in developed countries:
Ischemic Heart Disease
Name 2 groups of drugs used for the prophylaxis of angina pectoris:
Calcium Channel Blockers and Beta Blockers
Mainstay therapy for immediate relief of angina pectoris:
Organic Nitrates. Ex: Nitroglycerin
Most common cause of angina
Coronary Artery Disease (CAD). Atheromatous plaque
3 main classification of drugs used in treatment of angina pectoris:
Nitrates
Beta blockers
Calcium channel blockers
Which statement is false concerning claudication?
A. Disappears with rest
B. Results from obstruction (atheroma) in large & medium arteries
C. Occurs in skeletal muscles
D. Occurs during exercise
E. Treat with vasodilators
E. Conventional vasodilators are useless because vessels distal to obstruction are already dilated at rest
2 drugs used almost exclusively for peripheral artery dse:
Pentoxifylline: Xanthine derivative that reduces viscosity of blood
Cilostazol: PDE3 inhibitor. Probably has selective anti-platelet and vasodilating effects. MOA poorly understood
A patient has unstable angina with recurrent ischemic episodes at rest. What is the principle cause?
Recurrent platelet rich non-occlusive thrombus formation
First line therapy in treatment of CAD?
Reducing/stopping the risk factors like Smoking HTN Hyperlipidemia Obesity Clinical depression
In preventing MI, what are the 2 classification of drugs given? Give best answer
Anti-platelets: aspirin, ADP receptor blocker
Lipid lowering agents: statins
Antiangina drug that works by reducing late sodium current (I sub NA). Remember late sodium channel helps calcium entry by sodium calcium exchanger. Resulting in dec intracellular calcium concentration A. Propranolol B. Verapamil C. Ranolazine D. Atosiban
C
What’s the point of using metabolic modulators like pFOX inhibitors as an antianginal drug?
They slightly inhibit fatty acid oxidation pathway in heart. This fatty acid oxidation uses oxygen. So by inhibiting the FA oxidation, you spare precious O2. Lessens the degree of ischemia
Direct effect or reflex effect of nitroglycerin? A. Dec HR B. Dec venous capacitance C. Inc afterload D. In cardiac force
D
Common SE of nitroglycerin: A. Apnea B. Diuresis C. Headache D. Dizziness
C. Throbbing headache
Drug useful in the prophylaxis of angina: A. Amyl nitrate B. Diltiazem C. Esmolol D. Sublingual isosorbide dinitrate
B
Beta blockers for patients with chronic angina help because they:
A. Block exercise induced tachycardia
B. Dec. end diastolic ventricular volume
C. Inc double product
D. Inc cardiac force
A
The drugs prazosin and nitroglycerin have this in common: A. Bradycardia B. SLE like symptoms C. Orthostasic hypotension D. Throbbing headache
C
Pt comes to the ER because of a drug OD. He is hypotensive and has severe tachycardia. He has been receiving therapy for hypertension and angina. Which drug causes tachycardia? A. Isosorbide dinitrate B. Clonidine C. Propranolol D. Verapamil
A
Man presents with SOB, brownish cyanosis appearance and hypotension. Which drug causes methemoglobinemia? A. Amyl nitrate B. Isosorbide dinitrate C. Isosorbide mononitrate D. Sodium cyanide
A
Which drug inhibits PDE5 that inactivates cGMP? A. Sildenafil B. Hydrazaline C. Terbutaline D. Atenolol
A
Calcium chancel blockers and beta blockers both have an effect on: A. End diastolic cardiac size B. Heart rate C. Increasing cardiac force D. Vascular tone
A
What do you give during a digoxin OD?
Digoxin antibodies or Digibind
Which drug class prolongs life in CHF? A. Beta blockers B. Dobutamine C. Digoxin D. Spironolactone
A
Which drug decreases mortality in CHF patients? A. Beta blockers B. Dobutamine C. Digoxin D. Spironolactone
D
