Exam 4 Flashcards

(53 cards)

1
Q

Islet of Langerhans cells

A

Alpha cells: glucagon
Beta cells: insulin and amylin
Delta cells: somatostatin and gastrin

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2
Q

Glucagon

A

stimulated by endocrine syst. in low glucose levels (hypoglycemia)
-acts in the liver as glycogen and increased blood glucose concentration by breaking down stored glucose

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3
Q

Insulin

A

uptakes cellular glucose and through a negative feedback loop
-triggered by hyperglycemia

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4
Q

Amylin

A

promotes satiety (fullness)
-delays gastric emptying

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5
Q

Somatostatin

A

regulates alpha and beta cell function by inhibiting the secretion of insulin, glucagon and pancreatic polypeptide
-prevents hypertrophy
-is NECESSARY

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6
Q

Gastrin

A

secreted gastric (hydrochloric acid) acid which helps to break down food

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7
Q

hormone degradation

A

when the hormone is deactivated while on the way to it’s target

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8
Q

down regulation

A

less receptors

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9
Q

Hyperglycemia

A

-polyuria
-polyphagia
-polydipsia
-fatigue
-weight loss

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10
Q

Hypoglycemia
<40 mg/dl blood glucose

A

-only glucose is needed
-cold and clammy
-fatigue
-diaphoresis
-tremors
-irritability
stupor/coma
-altered mental state
-seizure
-death

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11
Q

polydypsia

A

due to excess volume/ urine loss

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12
Q

polyphagia

A

cells thinking there is not enough sugar to be consumed

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13
Q

polyuria

A

due to a hyperosmolar state which magnetizes water

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14
Q

Metabolic Syndrome

A

-triglyceride: > or equal to 150
-Waist circumference: >40 in. in men, > 35 in. in women. (BMI >25)
-Low HDL level: <40 in men, <50 in women
-Hypertension: < 130/85
-Fasting Plasma Glucose: >100mg/dl

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15
Q

what can metabolic syndrome lead to

A

diabetes, stroke, heart disease

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16
Q

upper urinary system

A

2 ureters
2 kidneys

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17
Q

lower urinary system

A

bladder
urethra

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18
Q

nephron

A

the functional unit of the kidney

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19
Q

Type 1 Diabetes
-cause and information

A

-idiopathic (unknown cause)
-autoimmune/ genetic
-irreversible
-pancreatic dysfunctioning of cells or the cells are destroyed
-NO insulin production
-no glucose enters the cell –> hyperglycemia

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20
Q

Type II Diabetes risk factors

A

-age
-obesity
-sedentary lifestyle
-African Americans & native americans
-hypertension
-prediabetes

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21
Q

Type II diabetes and information

A

Insulin resistance: decreased effectiveness of the cells insulin receptors because of high blood glucose
- leads to hyperglycemia
-pancreatic islet cells become dysfunctional

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22
Q

Macroangiopathy

A

affects large blood vessels
-leads to tissue necrosis
-in small blood vessels: thickening and hardening of the capillary basement membrane (AKA glycation) and tissue necrosis

23
Q

Microvascular

A

Can Cause:
-retinopathy (blindness)
-neuropathy
-nephropathy (damages glomeruli)

24
Q

Macrovascular

A

Causes:
-cardiovascular (accelerated atherosclerosis)
-cerebrovascular (increased risk for ischemic/thrombotic stroke)
-peripheral vascular (damaged nerves - gangrene)
-Infection

25
Hemoglobin A1C
tests the RBCs for how much glucose they have had in the past 90 days - RBCs live for 120 days >6.5% normal: <5.5%
26
Eosinophilic Esophagitis
idiopathic chronic inflammatory disease of the esophagus -WBCs collect in the inner lining causing inflammation and narrowing Manifestations: -dysphagia, food impaction, vomiting, stomach pain Evaluation: Biopsy Treatment: -No cure
27
Constipation
difficult/ infrequent defecation -caused by a sedentary lifestyle, low-residue diet, low fluid intake, medication, OPIOIDS, neurogenic disorders Manifestations: -straining, lumpy/hard stools, <3 bowel movements a week Evaluation: stool diary, description, current medication use Treatments: increase fiber intake, moderate exercise, drink more fluids
28
Diarrhea
-loose/water stools ->3 stools in 24 hours Manifestations: dehydration, weight loss, electrolyte imbalance, fever cramping w/ infection Evaluation: -abdominal imaging, travel questionnaire -biopsies
29
Gi Bleed
-Upper: bleeding in the esophagus (bright red), bleeding from the stomach and duodenum (dark red) -Lower: bleeding in the jejunum, ileum, colon, or rectum\ most common: hemorrhoids (bright red stool) Manifestations: changes in HR and BP Treatment: can resolve on its own depends on where bleed
30
GERD
reflux of acid from the stomach into esophagitis -vomiting, coughing, lifting, bending, obesity, can increased abdominal pressure Manifestations: heartburn, acid regurgitation, dysphagia, laryngitis, upper abdominal pain within 1 hour of eating Evaluation: biopsy, endoscopy Treatment: weight reduction, smoking cessation, head elevation, avoiding tight clothing
31
Pyloric Obstruction
narrowing or blocking of the opening between the stomach and the duodenum -tumors and ulcers can cause obstruction Manifestations: epigastric fullness, nausea, epigastric pain anorexia, weight loss, distention, vomiting severe malnutrition, dehydration' Treatment: nasogastric suctioning to relieve distention, surgery Evaluation: abdominal ultrasound, endoscopy, blood test
32
Intestinal Obstruction
caused by anything that prevents the normal flow of chyme through the intestinal lumen -small bowel obstructions are caused by postop adhesions, tumors, crohn's disease, hernias Manifestations: colicky pains, nausea and vomiting, sweating, tachycardia, rebound tenderness Treatment: early identification, replace fluid and electrolytes, decompression of lumen with suction, surgery Evaluation: CT, X ray, enhanced imaging
33
Duodenal Ulcers
commonly caused by H. pylori infections Manifestations: chronic epigastric pain, pain begin 2/3 hours after eating, pain is rapidly relieved by antacids or food ingestion, bleeding Treatment: the aim is to relieve causes and effects of hyperacidity, antacids neutralize gastric contents and relieve pain, surgery Evaluation: endoscopy, biopsy
34
Kidney Stones
masses of crystals, protein or other substances that are common urinary tract obstruction -common stone types are CALCIUM oxalate or phosphate Manifestations: moderate to severe pain that is radiating lower urinary tract symptoms (urgency/frequency/incontinence) indicate obstruction of the lower ureter Treatment: manage acute pain, promote stone passage, reduce the size of stones that are already formed, prevent new stone formation Evaluation: urinalysis , imaging studies, history
35
Renal Carcinoma
usually occurs in men between the ages of 50 and 60 -risk factors: obesity, cigarette smoking, uncontrolled hypertension Manifestations: hematuria, dull aching flank pain, weight loss Treatment: removal of infected kidney, chemotherapy, radiation, immunotherapy Evaluation: tumor staging, imaging, lab tests
36
Bladder Tumors
bladder cancer is most common in men >60 years risks: people who smoke Manifestations: gross painless hematuria Treatment: cystoscopy with tissue resection, biopsy, chemotherapy, immunotherapy Evaluation: uring cytologic study for screening, imaging, lab tests
37
UTI Cystitis
inflammation of the bladder -infection organisms is most commonly E. coli Manifestation: common- frequency, urgency, dysuria, painful , lower back pain, suprapubic pain severe- hematuria, cloudy urine, back pain - more serious elderly- confusion, abdominal discomfort Evaluation: urine culture Treatment: antibiotics
38
Regeneration
when damaged tissue is replaced with healthy tissue of the original type -by mitoses??
39
Restoration also called resolution (or maturation)
restoration of function and complete healing if the damage is minor with no complications
40
Repair
the replacement of destroyed tissue with scar tissue
41
Scar tissue
composed primarily of collagen - its a substance that fills in the lesion, restoring tissue integrity and strength -results in a LOSS of FUNCTION
42
Wound Healing Phases
1. Inflammation/ Hemostasis 2. Proliferative/ Granulation 3. Remodeling/ Maturation
43
Inflammation/ Hemostasis
-coagulation (blood clot/ scab) -platelets & macrophages & neutrophils 3 to 5 days
44
Proliferation/ Granulation
-angiogenesis (formation of new blood vessels) -epithelialization (sealing of the wound) -fibroblast and collagen formation -wound contraction (shrinking of wound) -lymphocytes
45
Remodeling/ Maturation
-weeks to months (2years?) -continuation of cellular differentiation -scar tissue formation (no function) -scar remodeling -contraction can occur by myofibroblasts
46
Primary Intention
-margins are well approximated - abrasions -3 to 5 days -surgical incision and clean incision most rapid healing minimal tissue loss -suture, staples, butterfly, and glue high risk of getting infection
47
Secondary Intention
would margins are not well approximated -larger wound area requres granulation tissue to fill the gap gaping would open wound and requires alot of tissue replacement longer period of time needed to heal
48
Tertiary Intention
would healing is DELAYED -a would that was open and is now closed large infected or contaminated wound increased granulation and late suturing with the wide scar (dog or human bite)
49
Dysfunctional Wound Healing
can occur at any stage -ischemia excessive bleeding excessing fibrin deposition predisposing disorders : -diabetes -obesity -wound infection -tobacco smoking
50
Dysfunctional Wound Healing: reconstructive phase
Dysfunctional collagen synthesis leads to keloid or hypertrophic scar
51
Dysfunctional Wound Healing: wound disruption
dehiscence (wound splitting open) increases risk of infection
52
Dysfunctional Wound Healing: impaired contraction
contracture (usually at joints and causes a loss of joint function)
53
fasting plasma glucose
>126 md/dl normal : <100