Exam 4 Flashcards

(49 cards)

1
Q

Parasites as prey

A

Things that exist as large numbers are food for other species
- another creature can feed
- organisms that eat parasites because compatibility filter are closed, they can be eaten

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2
Q

majority of environments

A

parasites play nonlegable roles in food webs

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3
Q

Metabolic theory

A

relationship between body size and reprodoctive rate
- larger organisms require more energy

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4
Q

Smaller organisms with higher metabolic rate

A

lose heat faster but require fewer resources

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5
Q

Parasites are outliers of metabolic theory

A
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6
Q

Parasites interact with other stressors to modulate host fitness

A

Temporary are more stressful environments. orgs could try to compete with water is drying

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7
Q

Control

A

infection/Transmission vs. Morbidity

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8
Q
  1. Elimination of disease
A

as a public health problem

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9
Q
  1. Elimination of infections
A

in a defined geographic area

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10
Q
  1. Eradication
A

no longer “out there”

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11
Q
  1. Extinction
A

no longer ANYWHERE

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12
Q

Why should we seek to eliminate parasitic disease?

A

expensive and vicious cycle of disease

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13
Q

role of human condition in parasitic transmission

A
  • disease of poverty
  • lack of access to adequate sanitation
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14
Q

Access to water, sanitation, hygeine…

A

critical for all parasitic disease with fecal-oral (trophoc accident) transmission to and/or from humans

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15
Q

(3) the toles of human behavior in oarasitic transmission

A
  1. dietary choices, eating raw meat/fish
  2. use of human feces for fertilizer
  3. use of raw animal flesh as poultice
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16
Q

(4) How to prevent trophically transmitted infections

A
  1. modern farming practices + food inspections
  2. cook at meat
  3. no consumption of game
  4. going veg(etari)an
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17
Q

Anasakiasis

A
  • nematode infection
  • L3 larvae penetrate human stomach lining after comsumption
  • fishing, when they didnt gut first, they got sick
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18
Q

(2) targeting vectors to control vector borne disease

A
  1. behavioral interventions - teach humans to avoid bites
  2. improve dwellings - screens on windows, rood made w/ non infestive material
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19
Q

biological control (targeting vectors to control vector borne diseases

A

introduce (or increase abundance) of a species that will kill the vector

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20
Q

Biological control consequences

A

becomes invasive when they have no natural predators

21
Q

Tse Tse flies

A

blue colors in mesh that has insecticide attracts flies that has T. brucei gambiense

22
Q

transgenic vectors

A
  • reducing pop. fecundity
  • making the vectors resistant to infection
23
Q

inducible toxin expression

A

tet repressor prevents expression of a dominant lethal gene in males
in the absence of tetracycline, males die

24
Q

why are there more anti-parasitic vaccines available to vetinary use

A

safety thresholf is lower than for human vaccines

25
(5) effective vaccine characteristics
1. safety 2. protective 3. sustained protection 4. induction of humoral and cell-mediated responses 5. practical considerations
26
(5) Why is it so difficult to make a good anti-parasitc vaccine?
1. Absence of natural sterililizing immunity after exposure to infection 2. antigenic variation 3. strain-specific variation of key antigens 4. need for a strong cellular (not humoral) response 5. Developmental variations
27
what are the 2 antiparasitic vaccines for human use?
1. Unlicensed leishmania vaccine (live parasite). Discontinued 2. RTS,S subunit vaccine, Plasmodium liver stage
28
Vaccine strategies: Whole Organism
1. Vaccinate wtih a closely related strain/species that is safe 2. Heat-killed 3. Attenuated
29
Vaccine strategies: Recombinant, subunit vaccines
acellular vaccines that target one (or a few) parasites proteins
30
Whole Organism Vaccines: Pros and cons
Pro: Greater efficacy Con: lesser safety
31
Subunit Vaccines: Pros and cons
Pro: Greater safety Con: Lesser efficacy
32
Conjugate vaccine: subunit vaccine
multiple antigens to procoke strong B cell and T cell responses
33
DNA vaccine
Human transfecction The vaccinee will produce the protein to drive the immune response
34
mRNA Vaccine
35
Adjuvant
- something that enhances the immune response to an antigen - adjuvants do not induce immunity by themselves - usually critical for subunit vaccines
36
Antimalarial/antiplasmodial vaccines
anti-sporozoites anti-liver stage ant-asexual blood stage anti-gametocytes
37
Targetint the sporozoite/liver stage
requires an abortive liver stage
38
Chemoprevention (prophylaxis)
Use of small molecules (aka drugs) to PREVENT a disease/infection
39
Chemotherapy
use of small molecules (aka drugs) to TREAT a disease
40
What makse a good antiparasitic drug?
Specificity: kills parasites, but not hosts
41
Therapeutic index
Toxic(human) dose / Effective (antiparasitic) dose
42
How do antiparasitic drugs work? + ideal
many different mechanisms of action but IDEALLY target an essential enzyme or pathway in the parasite not found in humans
43
ATP competitive inhibitors
drugs could work by competing with ATP for occupancy of the bidning pocket
44
Targeting Vectors - Drugs (insecticides)
DDT (dichlorodiphenyltricloroethane -killed chickens and birds. therefore inhibition of calcium, weak eggs
45
DDT resistance in mosquitos
in the card
46
How does drug resistance emerge
- naturally - resistance alleles are always present, can be selsected by drug pressure
47
Monotherapies select for drug resistance
Drug with all possible resistance drugs instead of one by one combination therapy
48
Praziquantel
key therapy for schistomiasis
49