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Anesthesia Pharm Doses/MAC/Coefficients > Exam 4: LA Lecture 2-3 > Flashcards

Exam 4: LA Lecture 2-3 Flashcards

(50 cards)

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1
Q

Antiarrhtymic Drug Class for Sodium-channel blockers

A

Class 1

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2
Q

Lidocaine Intraop Dose

Bolus and Infusion

A

1 mg/kg infusion over 1hr

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3
Q

Lidocaine
Amide or Ester
Initial Bolus Dose
Gtt Dose

A

Amide
1-2 mg/kg IV over 2-4 min. (bolus)
1-2 mg/kg/hr (gtt)
Terminated 12-72 hrs

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4
Q

Plasma Lidocaine Concentration Effect
1-5 (mcg/ml)

A

Analgesia

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5
Q

Plasma Lidocaine Concentration Effect
5-10 (mcg/ml)

A

Circum-oral numbness
Tinnitus
Skelatal muscle twitching
Systemic hypotension
Myocardial Depression

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6
Q

Plasma Lidocaine Concentration Effect
10-15 (mcg/ml)

A

Seizures
Unconsciousness

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7
Q

Plasma Lidocaine Concentration Effect
15-25 (mcg/ml)

A

Apnea
Coma

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8
Q

Plasma Lidocaine Concentration Effect
>25 (mcg/ml)

A

CV depression

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9
Q

Name the Esters

A

Procaine
Chloroprocaine
Tetracaine

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10
Q

Procaine
Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH
Fraction Non ionized at 7.6 pH

A

Potency: 1
Onset: Slow
Max single Dose: 500
PK: 8.9
Protein Binding: 6
Fraction Non ionized at 7.4 pH: 3
Fraction Non ionized at 7.6 pH: 5

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11
Q

Chloroprocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Rapid
Max single Dose: 600
PK: 8.7
Protein Binding: n/a
Fraction Non ionized at 7.4 pH: 5
Fraction Non ionized at 7.6 pH:7

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12
Q

Tetracaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 16
Onset: Slow
Max single Dose: 100
PK: 8.5
Protein Binding: 76
Fraction Non ionized at 7.4 pH: 7
Fraction Non ionized at 7.6 pH: 11

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13
Q

Name the Amides

A

Lidocaine
Prilocaine
Mepivacaine
Bupivacaine
Levobupivacaine
Ropivacaine

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14
Q

Lidocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Rapid
Max single Dose: 300
PK: 7.9
Protein Binding: 70
Fraction Non ionized at 7.4 pH:25
Fraction Non ionized at 7.6 pH: 33

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15
Q

Prilocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Slow
Max single Dose: 400
PK: 7.9
Protein Binding: 55
Fraction Non ionized at 7.4 pH: 24
Fraction Non ionized at 7.6 pH: 33

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16
Q

Mepivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Slow
Max single Dose: 300
PK: 7.6
Protein Binding: 77
Fraction Non ionized at 7.4 pH: 39
Fraction Non ionized at 7.6 pH: 50

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17
Q

Bupivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 175
PK: 8.1
Protein Binding: 95
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: 24

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18
Q

Levobupivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 175
PK: 8.1
Protein Binding: >97
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: 24

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19
Q

Ropivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 200
PK: 8.1
Protein Binding: 94
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: N/A

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20
Q

Lidocaine
Max infiltration Plain
Max Infiltration w/ Epi

A

300 mgs
500 mgs

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21
Q

Procaine Lipid Solubility

Study These Flashcards
A

0.6 (Least Esters)

22
Q

Tetracaine Lipid Solubility

Study These Flashcards
A

80 (Most Esters)

23
Q

Lidocaine Lipid Solubility

24
Q

Prilocaine Lipid Solubility

Study These Flashcards
A

0.9 (Least Amides)

25
Mepivicaine Lipid Solubility
1
26
Bupivacaine Lipid Solubility
28 (Most Amides)
27
what is the duration of action for Bupivacaine ER (Exparel)?
Up to 96 hours
28
State the LA equivalent to MAC (volatiles)
MEC or Cm (LAs)
29
How many nodes of ranvier are in a 1 cm block?
At least 2, preferably 3 Nodes of Ranvier
30
**Bupivivacaine** *Protein Bound Arterial Concentration*
Protein Bound: 95 % Arterial Concentration: 0.32
31
**Lidocaine** *Protein Bound Arterial Concentration*
Protein Bound: 95 % Arterial Concentration: 0.32
32
**Prilocaine** *Protein Bound Arterial Concentration*
Protein Bound: 55 % Arterial Concentration: 0.85
33
**Lidocaine Max Infiltration Dose** *Plain w/ Epi*
Plain: 300 mgs w/ Epi: 500 mgs
34
**Prilocaine Max Infiltration Dose** *Plain*
600 mgs
35
**Methylene Blue ** *Over 5 min dose Total max dose*
5 min: 1-2 mgs/kg IV Total Dose: 7-8 mg/kg
36
Benzocaine Dose
200-300 mgs/ brief spray
37
How many mls of 8.4% Sodium Bicarb are added per 30 ml of LA?
1 ml
38
How many mcg/ml of epi are in a 1:200,000 solution of LA w/ epi?
5 mcg/ml
39
Epi SAB/spinal dose w/ bupivacaine or lidocaine
0.2 mg
40
Phenyleprine SAB/spinal dose w/ bupivacaine or lidocaine
2 mg
41
How many mgs/ml in a 1% solution?
10 mgs/ml
42
**Mepivacaine ** *Plain W/ Epi*
Plain: 400 W/ Epi: 500
43
**Bupivacaine ** *Plain W/ Epi*
Plain: 175 W/ Epi: 225
44
Name the 2 components of EMLA cream?
Lidocaine 2.5% Prilocaine 2.5% Total: 5% LA
45
State the SAB calculation for LA
5ft=1 ml Per 1 inch > 5ft= 0.1 1 ml+ (0.1x (in>5ft)=Total Dose
46
What is the diluted % of lidocaine in Tumescent Liposuction?
0.05%-0.10%
47
What is the epi concentration in Tumescent Liposuction?
1:100,00
48
State the regional anesthesia lidocaine w/ epi dose in tumescent liposuction.
7 mg/kg
49
State the diluted lidocaine with epi in tumescent liposuction.
35-55 mg/kg
50
1 gm of SQ can absorb up to ___ mg of lidocaine
1 mg

Anesthesia Pharm Doses/MAC/Coefficients (16 decks)

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