Exanthems

Question 1

Slapped cheek appearance

Answer 1

Parvo B19

Question 2

Reticulated rash on trunk, child looks fine

Answer 2

Parvo B19

Question 3

Parvo B19 in pregnancy can cause

Answer 3

Hydrops featalis

Question 4

Why does Pavo B19 cause aplastic crisis in SS patients?

Answer 4

It causes a maturation arrest at pronormoblast and proerythroblast stage

Question 5

Papular-purpuric gloves and socks syndrome

Answer 5

Parvo B19

Question 6

What virus causes erythema infectiosum?

Answer 6

Parvo B19

Question 7

How do you diagnose Parvo B19?

Answer 7

Clinical & epi, IgM, PCR, BM biopsy (maturation arrest)

Question 8

Are children with Parvo rash infectious?

Answer 8

No

Question 9

Parvo B19 virology

Answer 9

ssDNA, icosahedral

Question 10

ssDNA, icosahedral

Answer 10

Parvo B19

Question 11

ssRNA, icosahedral, capsule

Answer 11

Rubella

Question 12

ssRNA, helical

Answer 12

Measles

Question 13

High fever followed by rash beginning on trunk

Answer 13

Roseola

Question 14

Koplik spots, rash spreads from face to trunk, sick child

Answer 14

Measles

Question 15

URI & systemic symptoms, petechiae on softr palate, quick-spreading rash

Answer 15

Rubella

Question 16

Can cause giant cell pneumonia in AIDS patients

Answer 16

Measles

Question 17

Can cause subacute sclerosing panencephalitis years later

Answer 17

Measles

Question 18

Blueberry muffin baby (dermal hematopoesis)

Answer 18

Rubella (late congenital)

Question 19

Low BW, cataracts, deafness, glaucoma, heart disease, mental retardation

Answer 19

Rubella (early congenital)

Question 20

Most common heart disease in early congenital rubella

Answer 20

PDA

Question 21

Pathogenesis of measles

Answer 21

Respiratory, epithelial cells (URI), viremia, reticulondothelial cells, viremia, WBC & macrophages, skin & resp tract

Question 22

What is the pathogenesis of Koplik spots?

Answer 22

T cells attack endothelial cells in dermal capillaries

Question 23

Forcheimer’s sign

Answer 23

petichiae on soft pallate (Rubella)

Question 24

Exanthem that can cause arthritis

Answer 24

Parvo B19

Question 25

Measles diagnosis

Answer 25

Clinical, epi, IgM

Question 26

T or F | Live attentuated Measles vaccine can serve as post-exposure prophylaxis

Answer 26

True, up to 72 hrs after exposure

Question 27

surface spikes contain hemagglutinin

Answer 27

Rubella

Question 28

What is the pathogenesis of ther rash in Rubella?

Answer 28

T cell attack on dermal capillaries * Ag-Ab complex mediated vasculitis

Question 29

Rash similar to measles but less red

Answer 29

Rubella

Question 30

dsDNA, eveloped

Answer 30

Herpes (roseola, varicella)

Question 31

Beta herpes virus

Answer 31

Roseola

Question 32

High fever, rash that starts on trunk

Answer 32

Roseola

Question 33

Can cause febrile seizures

Answer 33

Roseola

Question 34

Roseola diagnosis

Answer 34

PCR

Question 35

Eosinophilic intranucelar inclusiions & multinucelated giant cells in kidney cell culture

Answer 35

varicella-zoster

Question 36

Dewdrop on a rose petal

Answer 36

Varicella

Question 37

What shoudl you test for if a young, healthy individual presents with Zoster?

Answer 37

HIV

Question 38

May cause post-herpetic neuralgia

Answer 38

Zoster

Question 39

Patients with Hodgkin's treated with irradiationa nd chemo develop

Answer 39

Zoster

Question 40

What are the 2 major complications of Zoster?

Answer 40

Pneumonia (adults, immunosuppressed) Encephalitis (diffuse)

Question 41

Most common cause fo death for complicated varicella

Answer 41

Pneumonia

Question 42

Transmission of varicella occurs through

Answer 42

Respiratory droplets

Question 43

when is the varicella patient contagious?

Answer 43

1-2 days before rash

Question 44

Hutchinson's sign

Answer 44

V1 involvement of Zoster, refer to ophthamologist

Question 45

Ramsay-Hunt syndrome

Answer 45

CN VII involvement of varicella. may cause palsy, hearing & taste problems

Question 46

Mutinucleated giant cells seen on base of skin lesions

Answer 46

varicella (infected keratinocytes)

Question 47

Vesicular lesions of erythemetous base

Answer 47

Varicella

Question 48

What disease do enteroviruses cause?

Answer 48

hand-mouth-foot disease (herpangina)

Question 49

Examples of Enteroviruses

Answer 49

Echovirus, coxsackie, enterovirus, poliovirus

Question 50

Child 1-4, white vesicle on palms & soles, vesicles & erosions in uvula, tonsils, gigiva, palate, tongue, Lymphadenopathy, constitutional.

Answer 50

Coxsackie

Question 51

6 childhood exanthems

Answer 51

1. measles 2. Scarlet fever (strep pyogenes) 3. Rubella 4. Dukes 5. Parvo B19 6. Roseola (HHV-6/7)

Question 52

Treated with vitamin a

Answer 52

Measles

Question 53

When are Rubella patients infective?

Answer 53

A week before rash to 2 weeks after onset of rash

Question 54

Can have intermittent flares from enviornment

Answer 54

PArvo B19

Question 55

What causes exanthema subitum?

Answer 55

HHV-6

Question 56

Reactivation of this virus with drug exposure could lead to drug-induced hypersensitivity

Answer 56

HHV-6

Question 57

Pink macules and papules surrounded by white halos, beginning on trunk

Answer 57

Roseola

Question 58

Where does Roseola establish latency?

Answer 58

T lymphocytes (maybe salivary glands)

Question 59

Can cause mono-like illness in adults

Answer 59

Roseola (HHV-6)

Question 60

Alpha herpes

Answer 60

Varicella & Zoster

Question 61

When do varicella patients stop being infectious?

Answer 61

After all vesicles have crusted

Question 62

Most common varicella complication

Answer 62

Staph or GABHS superinfection

Question 63

Varivax vs Zostavax

Answer 63

Zostavax is 14X concentrated