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Fungi Flashcards

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1
Q

4 superficial mycoses

A

Ø Pityriasis (Tinea) versicolor
Ø Tinea nigra
Ø Black piedra
Ø White piedra

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2
Q

Cutaneous mycoses

A

Dermatophytosis

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3
Q

Subcutaneous mysoses

A

Sporotrichosis

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4
Q

Nodules on hair shaft caused by Piedraia hortae

A

Black piedra

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5
Q

Nodules on outside fo hair shaft caused by Trichosporon species

A

White Piedra

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6
Q

Hortaea (Exophiala) werneckii is the fungus reponsible for

A

Tinea negra

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7
Q

Disease? Organism?

A

Malassezia furfur

Tinea versicolor

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8
Q

Malassezia furfur causes which disease?

A

Tinea versicolor

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9
Q

Disease? Organism?

A

Tenia versicolor

Malassezia furfur

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10
Q

This disease causes catheder-associated sepsis in patients receiving prolonged intravenous lipids

A

Tenia versicolor

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11
Q

This disease has yellow-green flurescence under wood’s light

A

Tenia versicolor

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12
Q

Spaghetti & meatballs

A

Tenia versicolor

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13
Q

Disease?

A

Tenia versicolor

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14
Q

Needs long-chain fatty acids in media to grow

A

Tenia versicolor

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15
Q

Disease?

A

Tinea negra

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16
Q

Disease?

A

Tinea negra

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17
Q

Fungus found in soil and wood which causes macules in palms & soles

A

Tinea negra

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18
Q

How do you treat Tinea negra?

A

Topical drugs

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19
Q

Disease?

A

Tinea negra

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20
Q

Disease?

A

Tinea negra

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21
Q

Disease?

A

Black piedra

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22
Q

Disease?

A

White piedra

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23
Q

What are dermatophytes?

A

Keratonophilic fungi

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24
Q

What are the 3 genera of dermatophytes? what parts of the body do they infect?

A

Microsporum (hair, skin)

Epidermophyton (skin, nail)

Trichophyton (hair, skin, nail)

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25
What do **endothrix ** and **exotrhix** mean?
Hypahe fragment into conidia inside or outside of hair shaft
26
what is the **infective form** of dermatophytes?
Arthroconidia
27
What conditions do you use to culture dermatophytes?
Sabouraud's dextrose @ 25C pH = 5.2, Chloramphenicol & cycloheximide
28
Which dermatophytes has spherical microconidia that cluster along hyphae and few macroconidia?
trichophyton
29
Dermatophyte genera?
trichophyton
30
Dermatophyte genera?
Microsporum
31
Dermatophyte with spindle-shaped macroconidia and few microconidia?
Microsporum
32
Which dermatophyte has club-shaped macroconidia and no microconidia?
epidermophyton floccosum
33
Organism?
Epidermophyton fluccosum
34
Pathogenesis of dermatophytes
1. Arthospores adhere to keratinocytes 2. spores germinate and form mycelum 3. Proteinases and kinases secreted 4. Slow-growing, chronic infection 5. May cause id reactions
35
Disease? Most common organisms?
Tinea capitis Trychophyton tonsurans & microsporum canis
36
Disease? Most common organisms?
Tinea capitis Trichophytum tonsurans, microsporum canis
37
Disease? Most common organism?
Tinea corporis Trychopytum species
38
Disease? Most common organisms?
Tinea corporis Trychopytum species
39
Disease? Most common organisms?
Tinea cruri Epidermophyton floccosum, T. rubrum, T. mentagrophytes
40
Disease?
Tinea fasciae
41
Disease?
Tinea barbae
42
Disease?
Tinea pedis
43
Disease?
Tinea unguium
44
How do you treat onychomycosis?
Oral atifungals for 6-12 weeks (get incorporated into nail as it grows)
45
Sporothrix schenckii is the causative agent of
sporotrichosis
46
**Asteroid bodies** on biopsy
Sporotrichosis
47
Finding? Disease?
Asteroid body Sporotrichosis
48
Finding? Disease?
Cigar-shaped budding yeast Sporotrichosis
49
Finding? Disease?
daisy microconidia Sporotrichosis
50
Finding? Disease?
Linear subq nodules Sporotrichosis
51
Which fungi has centrally uncerated nodules & daisy microconidia?
Sporotichosis
52
Finding? Disease?
Cigar bodies Sporotrichosis
53
Finding? Disease?
Daisy microconidia (+septate hyphae) Sporotrichosis
54
How do you get infected with sporotrichosis?
Direct innoculation Aspiration (alcoholics & COPD)
55
What is the reservoir for sporotrichosis
Soil, decaying wood, vegetation
56
Disease most likely seen in rose handlers or those in contact with moss
Sporotrichosis
57
Pathogenesis of **Sporotrichosis**
1. Spores bind to extracell matrix 2. Local multiplication 3. Mixed pyogenic & granulomatous inflammation 4. Spread via lymphatics \*lesions are granulomas surrounded by PMNs, histiocytes, giant cells, lymphocytes, plasma cells
58
Clincial finding is sporotrichosis
* PRIMARY LESION * Painless papule evoled into pustule, then ulcerates * Minimal constitutional symptoms * SECONDARY LESION * ​spread up lymphatics proximally * suppurative, can caused lymphadenopathy
59
Disease?
Primary sporotrichosis
60
Disease?
Primary sporotrichosis
61
Disease?
Secondary sporotrichosis
62
Disease?
Secondary sporotrichosis
63
Major differential for sporotrichosis?
Non-TB mycobateria
64
Where can sporotrichosis disseminate?
Bone, lungs, CNS (multisystem)
65
Disease?
Sporotrichosis
66
T or F Sporotrichosis is dimorphic
True!
67
What is the **treatment** for sporotrichosis?
- Potassium iodide (localized or lymphatic) - Itraconazole or terbinafine - Amphotericin B (disseminated)
68
Myco that causes verrucous cauliflower-like lesions in extremities, especially legs
Chromoblastomycosis
69
How do you treat chromoblastomycosis?
Surgical removal + antifungals
70
Demataceous fungi (Fonsecaea, Phialphora, Cladosporium, Exophiala) cause which disease?
Chromoblastomycosis
71
disease? Organism?
Chromobalstomycosis Phialphora verrucosa
72
Finding? Disease?
Granulomatous inflammation, sclerotic (penny) bodies Chromoblastomycosis
73
Myco that causes suppurative & granulomatous inflammation with sclerotic bodies
Chromoblastomycosis
74
Myco that causes tumor-like growths, draining sinus tracts, & granules from traumatic implantation of organisms
Mycetoma (maduromycosis)
75
Which organisms can cause Mycetoma (maduromycosis)?
Bacterial (actinomycotic): nocardio, actinomyces, actinomadura, streptomyces Fungal (eumycotic): maduerlla, acremonium, apergillus... Black grain: most cmmon, dematicous fungi White grain : Pseudoallescheria boydii/scedosporium apiospermum most common
76
What are Dematiaceous fungi?
Dark-colored fungi (produce melanin)
77
Indolent myco that discolors skin, causes sinus tracts, and can spread to fascia, muscle, bone over decades
Mycetoma (maduromycosis)
78
disease?
Maduromycetoma (foot)
79
Disease?
Eumycotic mycetoma
80
Disease?
Actinomycotic mycetoma
81
Treatment fro mycetoma
Resection and/or amputation
82

Multisystem (5 decks)

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