export_immunomodulators Flashcards
(10 cards)
1
Q
Immune Mediated Haemolytic Anaemia (IMHA)
A
Secondary (inf, vaccines, drugs, Ag, neoplasia) or primary autoimmune disorder
2
Q
Name three types of immunosuppresive drugs:
A
- IL-2 inhib
- inhib cytokines
- inhib DNA synth
3
Q
What produced IL-2
A
Th1 CD4+
4
Q
What does IL-2 do?
A
- Th clonal expansion of CD8+
- B cell prolif
- Activate mphage/NK cells
5
Q
Name an IL-2 inhibitor
A
Cyclosporin.
- prev CD4+ activation
6
Q
What is cyclosporin used for?
A
Dry eye tx
= ‘Optimune’
7
Q
Name a Cytokine production inhibitor
A
Dexamethosone.
G-corticoid
8
Q
G-corticoid are risky, name some side effects
A
- Dependance : adrenal cortex will ‘turn off’, so must wean off steroids.
- Cortex also produced mineralocorticoids - animal wont have any reduce Ag and Ab presentation and recognition
9
Q
Drugs inhibiting DNA synth, particularly inhibit the synthesis of ______________ and __________
A
Pyramidine and Purines
10
Q
Purine synthesis is inhibited by
A
MMF
