export_viral stis ii Flashcards
(33 cards)
HSV primary infection
Lesion progresses from macules, papules, vesicles, pustules, to ulcers
Duration ~3 weeks
Symptoms more severe in women
Other HSV diseases
Herpetic whitlow, herpes labialis, herpes simplex keratitis, herpes simplex encephalitis
Neonatal herpes infection transmission and dissemination
Transmission most common when mother is experiencing primary infection
Requires treatment, or severity increases
Can disseminate to brain, liver, lungs, eyes
Treatment for neonatal herpes infection
IV administration of antivirals for all cases
HSV family and features
Herpesvirus family
Enveloped, dsDNA
HSV-1 viruses most commonly cause?
Oral lesions
HSV-2 viruses most commonly cause?
Genital lesions
HSV diagnosis
Clinical appearance of lesions (1-2 mm, in groups, vesicles - pustules - ulcers)
PCR can determine between HSV-1 and HSV-2
Oral HSV treatment
Usually not treated with antivirals
Genital herpes treatment
Primary - oral antivirals
Recurrent - long term oral antivirals
Neonatal HSV treatment
IV antiviral treatment
Ocular HSV treatment
Topical antiviral treatment
Nucleoside analogue
Prevents DNA polymerase from working appropriately
Nonnucleoside inhibitor
Inhibits viral DNA polymerase
Used in acyclovir-resistant HSV infections
Acyclovir, Famiciclovir, and Valacyclovir
Nucleoside analogue drugs for HSV
Foscarnet
Nonnucleoside inhibitor treatment for HSV
HPV disease
Genital warts
HPV symptoms
Most warts are asymptomatic
Others may experience itching, pain, or burning
Respiratory papillomatosis
Nodules on ciliated and squamous epithelial junction of the larynx
Need to be surgically removed
HPV family and features
Papovaviridae family
Non-enveloped, dsDNA
What comorbidity is commonly associated with HPV?
Cervical cancer
HPV virulence
Produces E6, which inhibits p53, and E7, which inhibits Rb
This allows the virus to produce its virions most effectively
What does E2 do?
This is a gene in the host cell that downregulates E6 and E7 expression
How does HPV result in cervical cancer?
The genome of the HPV is integrated into the host cell genome (randomly, this is NOT the normal event for HPV)
E2 is almost always disrupted in this process, resulting in uncontrolled E6/E7 production, which results in uncontrolled cell growth
Virion production is eliminated in these cells
