Extra Cellular Matrix Flashcards
(49 cards)
What is the complex in which cells hold onto eachother
Junctional complex
Ehich complex holds the cell to the external environment
Extracellular matrix
In cell motion what do microtubules do
Organise movement in the cell interior
What do actin microfilaments do in cell motion
Allows cells to move from one location to another
In cell motion what do intermediate filaments do
Maintain cell structure and resist external forces caused by movement
Cells adhere to ECM via which protein
Integrin
Function of collagen
Structural support
Which is the most abundant fibre
Collagen
How many sub units is collagen made of
3
Which is the repeated amino acid sequence in collagen
Glycine X amd Y
What gives collagen extra strength in terms of bonds
Covalent cross links between triple coil for extra strength
Examples of fibril collagen
Bone, cornea, internal organs, ligaments, skin, tendons,
Example of fibril associated collagen
Cartilage
Example pr network forming collagen
Basal lamina
Example of transmembrane collagen
Hemidesmosomes
Function of fibril collagen in terms of strength
Very strong along a single axis
Describe the strength of network collagen
Can withstand stretch in multiple directions
What does a FACIT do
Binds fibrils and network together
Define exocytosis
Intracellular trafficking through the secretory pathway
Where does fibril assembly begin
Fibripositors
Where is the fibril assembly completed
Extracellular space
Which modification is essential to form fibrils
Procollagen to mature collagen ii
Procollagen peptidase requires which co factor
Vitamin C
Mutations in the alpha proteins cause which diseases
Osteogenesis imperfecta or brittle bone disease
