Extraction Method

Question 1

Give 7 extraction method.

Answer 1

Liquid-liquid extraction (LLE)
Solid phase extraction (SPE) /solid liquid extraction (SLE)
Soxhlet Extraction (SE)
Microwave
Supercritical fluid
Accelerated solvent extraction
Ultrasonic
Blender

Question 2

Ideal properties of
the solvents

Answer 2

:
1. Be highly selective for the compound to be
extracted.
2. Not react with the extracted compound or
with other compounds in the plant
material
3. Have a low price.
4. Be harmless to man and to the
environment.
5. Be completely volatile.
6. Should not mix up with water.
7. Should have the big capacity in relation to
extractive.
8. The density of solvent should be difference
from water density.
9. Should have the minimum viscosity

Question 3

Factors affecting
extraction process (nstpp)

Answer 3

:
❑ Nature of drug
❑ Solvent
❑ Temperature
❑ p H
❑ Particle (size
kurang saiz better)

Question 4

Distribution Law

Answer 4

Aaq Aorg
• Distribution Law – solutes
distribution among two
different liquid phases -
equilibrium –
concentration ratio
constant at given
temperature.
 K = [Aorg]/ (1)
[Aaq]
K – distribution coefficient