Exudate and leuk migration Flashcards
Exudate fx
Dilute toxins
Distribute clotting factors and mediators around tissues
Distrib complement and Ab
Continuosly drained by lymphatics
Describe serous
Abundant Watery Clear/cloudy Low pro and cell Can coag at necropsy form loose jelly dep on fibrinogen content
Wear is serous found
Mild react involving serous mem synovial men and CT
Describe fibrinous
Abundant
Fibrinogen rich (most go to fibrin (can form yellow white elastic shaggy deposit))
Serous component w/in fibrin mesh pockets or accum as collections of clear yellow watery exudate
Where fibrinous found
More severe react involv serous mem CT alveoli
Describe catarrhal
Varies: Abundant cloudy thin mucinous to restricted thick sticky white mucinous
Large mucinous content
Rich in desquamated epi cells and neutrophils
Where cattarhal found
Assoc with inflam of muc mem of nasopharynx uterus airways mucous glands and lower alimentary tract
DescribeSuppurative/purulent
Opaque variable colour viscosity odour
Cont dead/dying neutr nevrotic tissue debris partly liquiefied
Breakdown products presenr eg fats soaps cholesterol
Colour dep onRBC presence and haemoglob breakdown and chomagenic bact pigments
Odour dep on breakdown products
Viscosity dep on DNA content
Where suppurative found
Usually localised (diffuse - cellulitis) Assoc with pyogenic bact
Describe haemorrhagic and where found
Frank haemorr may occur and dom exudate appearance esp in organ rich in vascular supply
Esp if agent dam vessel walls and alter coag mech
How necrotising arise and where
Result of ischaemia after vasc spasm or thrombosis or of acute venous congestion and stasis post strangulation or thrombosis of venous return
Vasc crisis may result from combination with necrotising toxins
Cause of incr lymphatic flow
Distension if tissue space by exudate cause wall of lymphatics to open wide
Drainage interference of lymphatic cause
Severe react - fibrin coag in lymphatics
Result of incr lymph flow
Bact or agent can be circulated around the body and set up 2o infect site (maybe in lymphatic tissue) or spread further and reach blood. Lymphatic vessels can become inflamed themselves
2 stages of leuk migration
Neutro margination on changed vasc endo acoimpanied by slowing blood flow
Active emigration through gaps between endo cells through Bm perivasc sheath and into tissue spaces
