PG And LT Flashcards
Eicosanoids
20C lipid mediator with homeostasis and inflamm roles. Effects mediated through GPCR eg PG and LT
AA synth
Most mammals (not cats) from linoleic acid (omega 6) PUFA
PG where synthed, action type and bio synth pathway
Prod in most body cells with autocrine and paracrine action
Synth de novo
Triggered by cytokine, ADP, bradykinin, trauma
PLA2 release AA
COX (target for aspirin and other PG synth inhibitors) convert it to PGH2
PGH2 can then be made into a variety of PGs
TXA2 story
Platelets produce
Cause vasoconstrict
Aggregation
PGI2 story
Endo cells prod
Cause vasodil
Disaggreg
PGF2 story
Uterus produced
Contraction and parturition
PGD2 story
Mast cell
Chemotaxis (lymphocyte)
Asthma (lung epi)
PGE2
Other cells Pain (spinal neuron) Pyrexia (neuron in POA) Bone resorption (osteoclast) Ovulation (ovarian cell)
PG action area
Act locally when transport out of cell as short 1/2 life, effect med by GPCR
LT production cells
Mast
Macroph
Polymorphonuclear leukocytes
LT biosynth
Bact peptide or imm complex trigger Release AA FLAP act 5LO 5LO and PLA2 convert AA to LTA4 LTA4 converted to diff LTs
LT effects
Med by GPCR 4 rec IDed Chemoattractant Neutrophil secretion Airway smooth m contraction Vascular endo cell express adhesion molecules
PG modifying drugs
NSAIDS target COX enz
COXIBs are COX-2 selective (COX type involved with inflam)
LT modifying drugs
5LO inhibitors and receptor antagonists
Used to manage asthma
