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Flashcards in Fast Pharm Deck (30):
1

Cimetidine, raniditdine, famotidine, nizatidine

histamine H2 blockers, reduce acid secretion, used to tx gastric/duodenal ulcers and GERD
cimetidine inhibits CYP450s

2

Bismuth subsalicyclate

w/magnesium aluminum silica clay antidiarrheal for treating travelers diarrhea
antimicrobial, anti inflammatory, antisecratory actions for sometimes treating ulcers
one arm of H. pylori tx

3

Metronidazole, clarithromycin, amoxicillin, tetracyclin

kill H. pylori, results in protection from GI wall associated bacterial-facilitated ulcer, used in combo w/bismuth subsalicylate, PPIs or H2 blockers

4

Misoprostol

prevents NSAID induced ulcers by prostaglandin replacements
contraindicated in pregnant/those planning to get pregnant

5

Omeprazole, esomeprazole, lansoprazole

PPIs (K/H/ATPase blockers)
inhibit acid secretion
drug of choice for ZE syndrome
for gastric/duodenal ulcers and GERD

6

Antacids

neutralize secreted acid
simethicone added as antifoaming agent to reduce gas

7

Mg(OH)2

antacid
can cause diarrhea and is cautioned in patients w/renal insufficiency

8

Al(OH)3

antacid
can cause constipation

9

Sucraflate

octasulface of sucrose and Al(OH)3
forms a polymer gel to coat stomach lining and protect it

10

Octreotide

somatostatin agonist used for carcinoid syndrome associated diarrhea

11

Metoclopramide

prokinetic, used for severe GERD and diabetic gastroparesis

12

Ondanseron, Granisetron

5-HT3 blockers which attenuate vomiting by both action at CTZ and visceral afferents
can be combined with dexamethasone to enhance effectiveness

13

Prochlorperazine

a DA2 antagonist used to treat nausea and vomiting

14

Dronabinol

THC used to treat chemo induced vomiting centrally, perhaps acting at the vomiting center in the medulla
used in cases where other therapies are ineffective

15

Erythromycin

prokinetic used to treat diabetic gastroparesis induced vomiting, non-antibiotic effect: acts like motilin to increase gastric emptying and duodenal motility

16

Dimenhydrinate

histamine-1 blocker, used to treat motion-induced vomiting

17

Scopolamine

antimuscarinic agent, historical treatment for motion sickness
it acts on the cortex & inner ear

18

Aprepitant

substance P receptor antagonist
used in combination therapy for the treatment of chemo assoc. nausea

19

Diphenoxylate

meperidine analog (opiod receptor agonist)
used to treat diarrhea
CNS effects at high dose

20

Loperamide

opiod receptro agonist
used to treat diarrhea
does not penetrate into the CNS

21

Docusae salts

reduces surface tension in stool (surfactant cathartic)
used to tx constipation

22

Lactulose

a nonabsorbed sugar fermented by bacteria to organic acids and causes osmotic retention of fluid
used to treat portal systemic encephalopathy and constipation

23

Polyethylene Glycol

is not absorbed and causes osmotic retention of water
used to treat constipation

24

Bisacodyl

a diphenylmethane, causes enteric mucosal irritation/inflammation to increase intestinal fluid accumulation
used to tx constipation

25

Lubiprostone

activates chloride channels to increase intestinal fluid secretion and intestinal motility. used to treat chronic constipation in adults and women w/IBS constipation

26

Methylnaltrexone

a peripherally acting opioid receptor antagonist used for the treatment of opioid induced constipation

27

Prednisone

a glucocorticoid anti-inflammatory used to treat acute attacks of inflammatory bowel disease or ulcerative colitis

28

Budesonide

an enteric release steroid used to treat Crohn's disease

29

Sulfasalazine, Olsalazine, Mesalamine

5-aminosaliclates (5-ASAs) used for the treatment of IBD

30

Infliximab

an immunoglobulin based therapy that binds TNFa
used to treat moderate to severe crohn's and ulcerative colitis