Liver tests/normal values Flashcards Preview

GI > Liver tests/normal values > Flashcards

Flashcards in Liver tests/normal values Deck (24):
1

AST (SGOT) normal?

10-45 U/L

2

ALT (SGPT) normal?

8-40 U/L

3

Alkaline Phosphatase normal?

40-129 U/L

4

Total Bilirubin normal?

0.2-1.0 mg/dL

5

Direct Bilirubin normal?

0-0.2 mg/dL

6

INR normal?

0.9-1.3

7

Albumin normal?

3.5-5 g/dL

8

GGT normal?

0-50 U/L

9

What does elevated ALT & AST indicate?

hepatocyte injury, ALT is more specific than AST

10

What does elevated alkaline phosphatase indicate?

biliary obstruction or cholestatic process

11

Where is alkaline posphatase usually found?

on the surface of the liver cells that is adjacent to the bile canaliculi

12

What does an elevated alkaline phosphatase with and elevated GGT indicate?

confirms reason for elevated alk phos elevation, if GGT also elevatd indicates a biliary cause
(hepatic, biliary tract, pancreas)

13

What can increased direct (CB) bilirubin indicate?

liver injury
bile duct problems
rare metabolic problems

14

What can increased indirect (UCB) bilirubin indicate?

hemolysis
Gilbert's

15

What do albumin and INR levels correspond to?

liver synthetic function
can be affected by poor nutrition and severe infections

16

What does an ALT >500 indicate?

hepatitis A or B infection

17

What does an AST:ALT ratio of >2:1 suggest?

alcoholic liver disease

18

Transaminases usually remain below what level in alcoholic liver disease?

300

19

What is cholestasis?

any condition in which the flow of bile from the liver is inhibited or blocked

20

What are the 2 isoforms of AST?

GOT1-cytoplasmic
GOT2-mitochondrial
(both require PLP cofactor)

21

What does ALT require as a cofactor?

PLP

22

Which is more specific for hepatocellular damage: ALT or AST?

ALT

23

Where is ALP found in the cell?

on the membrane

24

What conditions, besides biliary/cholestatic processes can cause an elevated ALP?

bone disorders and during growth and pregnancy