Fatty Acid Synthesis Flashcards
What are triglycerides?
Fats
Where does fatty acid synthesis mainly occur?
In the liver
What are the essential ingredients of fatty acid synthesis?
Acetyl CoA, NADPH and malonyl CoA
Why are the intermediates of fatty acid synthesis bound to a acyl carrier protein?
Because fatty acid synthesis is thermodynamically unfavourable.
What two pathways are responsible for chain elongation?
Microsomal and mitochondrial
At what point are humans unable to make unsaturated fatty acids?
Past carbon 9
What happens when you add a fatty acid to a glycerol?
A triglyceride is formed
Where does fatty acid synthesis occur?
In the cytoplasm
How many rounds of fatty acid synthesis are required to generate palmitate?
7
What happens on each round of fatty acid synthesis?
The fatty acid gains 2 carbons
What is the key regulation point of fatty acid synthesis?
acetyl CoA -> malonyl CoA. The enzyme catalysing this reaction, acetyl CoA carboxylase, is under allosteric regulation.
In fatty acid synthesis how is acetyl CoA carboxylase hormonally regulated?
It’s activity is increased by dephosphorylation and decreased by phosphorylation
What type of enzyme is required for i saturation of fatty acid chains?
Mixed function oxidase
