Regulation Of Central Metabolism Flashcards
What is allosteric inhibition?
Where a process is inhibited by the product.
What is the yield of ATP/glucose in aerobic and anaerobic conditions?
30ATP/glucose in aerobic conditions, 2ATP/glucose in anaerobic conditions.
How does a cell control glycolysis?
Alloterically through phosphofructokinase
Where does the hormonal control of glycolysis occur?
I’m the liver
What is the key control point of the TCA cycle?
When pyruvate is converted to acetyl CoA by pyruvate dehydrogenase. It is allosterically inhibited by NADH.
What are 3 TCA cycle inhibitors?
Citrate synthase - feedback inhibition, isocitrate dehydrogenase and a-ketoglutarate dehydrogenase
Where is the entry of glucose in glycolysis regulated in skeletal muscle cells?
When glucose is converted to glucose-6-P the enzyme hexokinase is allosterically inhibited.
Where is the entry of glucose in glycolysis regulated in the liver?
When glucose is converted to glucose-6-P the enzyme glucokinase is inhibited by insulin.
What are the two hormone-independent mechanisms of mobilising muscle glycogen?
Ca2+ ions and AMP
What is the role of fructose-2,6-bisphosphate?
It is a hormonal control for both glycolysis and gluconeogenesis
What controls fructose-2,6-bisphosphate?
Glucagon and insulin
What are the three controls of the TCA cycle?
Citrate Synthese, isocitrate dehydrogenase and a-ketoglutarate dehydrogenase
