Female Reproductive Organ Anatomy Flashcards
(10 cards)
Hymen
The hymen is a thin membrane found at the entrance to the vaginal orifice. Often, this membrane is perforated before the onset of menstruation, allowing the flow of menses. The hymen varies greatly in shape.
Clitoris
The clitoris is an erectile structure found beneath the anterior joining of the labia minora. Its width in an adult female is approximately 1 cm, with an average length of 1.5-2.0 cm. The clitoris is made up of two crura, which attach to the periosteum of the ischiopubic rami. It is a very sensitive structure, analogous to the male penis. It is innervated by the dorsal nerve of the clitoris, a terminal branch of the pudendal nerve. Studies have shown that total clitoral size averages 9-11 cm, mostly internal. It contains over 8,000 sensory nerve endings. [6, 7]
Vestibule and urethra
Between the clitoris and the vaginal introitus (opening) is a triangular area known as the vestibule, which extends to the posterior fourchette. The vestibule is where the urethral (urinary) meatus is found, approximately 1 cm anterior to the vaginal orifice, and it also gives rise to the opening of the Skene glands bilaterally. The urethra is composed of membranous connective tissue and links the urinary bladder to the vestibule externally. A female urethra ranges in length from 3.5 to 5.0 cm.
Skene and Bartholin glands
The Skene glands secrete lubrication at the opening of the urethra. Skene glands are recognized as homologous to the male prostate. [8] The greater vestibular (Bartholin) glands are also responsible for secreting lubrication for the vagina, with openings just outside the hymen, bilaterally at the posterior aspect of the vagina. Each gland is small and similar in shape to a kidney bean.
Vestibular bulbs
Finally, the vestibular bulbs are two masses of erectile tissue that lie deep to the bulbocavernosus muscles bilaterally.
The mons pubis is the rounded portion of the vulva where sexual hair development occurs at the time of puberty. This area may be described as directly anterosuperior to the pubic symphysis and adjacent pubic bone. [1] The mons pubis is a fatty cushion, which provides mechanical protection during sexual intercourse. It also contains sebaceous glands that secrete pheromones. [5]
Sections
Overview
Female reproductive organs, anterior view.
Female reproductive organs, anterior view.
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Female reproductive organs, sagittal section.
Female reproductive organs, sagittal section.
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Gross Anatomy
External Genitalia
The vulva, also known as the pudendum, is a term used to describe those external organs that may be visible in the perineal area (see the images below). The vulva consists of the following organs: mons pubis, labia minora and majora, hymen, clitoris, vestibule, urethra, Skene glands, greater vestibular (Bartholin) glands, and vestibular bulbs. [2, 3, 4] The boundaries include the mons pubis anteriorly, the rectum posteriorly, and the genitocrural folds (thigh folds) laterally.
External female genitalia.
External female genitalia.
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Deeper view of external structures.
Deeper view of external structures.
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Mons pubis
The mons pubis is the rounded portion of the vulva where sexual hair development occurs at the time of puberty. This area may be described as directly anterosuperior to the pubic symphysis and adjacent pubic bone. [1] The mons pubis is a fatty cushion, which provides mechanical protection during sexual intercourse. It also contains sebaceous glands that secrete pheromones. [5]
Labia
The labia majora are two large, longitudinal folds of adipose and fibrous tissue. They vary in size and distribution from female to female, and the size is dependent upon adipose content. They extend from the mons anteriorly to the perineal body posteriorly. The labia majora have hair follicles on the external pigmented surface. The internal surface is smooth and bears large sebaceous follicles. Loose connective and adipose tissue intermixed with smooth muscle (resembling the dartos muscle of the scrotum) is present between these surfaces. [1]
The labia minora, also known as nymphae, are two small cutaneous folds that are found between the labia majora and the introitus or vaginal vestibule. Anteriorly, the labia minora join to form the frenulum of the clitoris.
Hymen
The hymen is a thin membrane found at the entrance to the vaginal orifice. Often, this membrane is perforated before the onset of menstruation, allowing the flow of menses. The hymen varies greatly in shape.
Clitoris
The clitoris is an erectile structure found beneath the anterior joining of the labia minora. Its width in an adult female is approximately 1 cm, with an average length of 1.5-2.0 cm. The clitoris is made up of two crura, which attach to the periosteum of the ischiopubic rami. It is a very sensitive structure, analogous to the male penis. It is innervated by the dorsal nerve of the clitoris, a terminal branch of the pudendal nerve. Studies have shown that total clitoral size averages 9-11 cm, mostly internal. It contains over 8,000 sensory nerve endings. [6, 7]
Vestibule and urethra
Between the clitoris and the vaginal introitus (opening) is a triangular area known as the vestibule, which extends to the posterior fourchette. The vestibule is where the urethral (urinary) meatus is found, approximately 1 cm anterior to the vaginal orifice, and it also gives rise to the opening of the Skene glands bilaterally. The urethra is composed of membranous connective tissue and links the urinary bladder to the vestibule externally. A female urethra ranges in length from 3.5 to 5.0 cm.
Skene and Bartholin glands
The Skene glands secrete lubrication at the opening of the urethra. Skene glands are recognized as homologous to the male prostate. [8] The greater vestibular (Bartholin) glands are also responsible for secreting lubrication for the vagina, with openings just outside the hymen, bilaterally at the posterior aspect of the vagina. Each gland is small and similar in shape to a kidney bean.
Vestibular bulbs
Finally, the vestibular bulbs are two masses of erectile tissue that lie deep to the bulbocavernosus muscles bilaterally.
Internal Genitalia
Vagina
The vagina extends from the vulva externally to the uterine cervix internally. It is located within the pelvis, anterior to the rectum and posterior to the urinary bladder. The vagina lies at a 90° angle in relation to the uterus. The vagina is held in place by the endopelvic fascia and ligaments (see the image below). The vagina averages about 7.5-10 cm in length, with a distinct muscular layer that supports flexibility and expansion. [9, 10]
Superior view of pelvic organs.
Superior view of pelvic organs.
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The structure of the vagina is a network of connective, membranous, and erectile tissues: an outer fibrous layer (adventitia), a central smooth muscle layer, and an inner mucosal layer with rugae, which provide elasticity. The vaginal rugae are situated in folds throughout. These allow easy distention, especially during childbearing. [3, 9, 10]
The pelvic diaphragm, the sphincter urethrae and transverse peroneus muscles, and the perineal membrane support the vagina. The sphincter urethrae and the transverse peroneus are innervated by perineal branches of the pudendal nerve. The pelvic diaphragm primarily refers to the levator ani and the coccygeus and is innervated by the branches of sacral nerves S2-S4.
The vascular supply to the vagina is primarily from the vaginal artery, a branch of the anterior division of the internal iliac artery. Several of these arteries may be found on either side of the pelvis to richly supply the vagina.
The nerve supply to the vagina is primarily from the autonomic nervous system. Sensory fibers to the lower vagina arise from the pudendal nerve, and pain fibers arise from the sacral nerve roots.
The vaginal microbiome, dominated by Lactobacillus species, creates an acidic pH (around 4.5) that aids in the vagina’s immune defense. Disruptions to this microbiome can lead to infections. [11]
Lymphatic drainage of the vagina is generally to the external iliac nodes (upper third of the vagina), the common and internal iliac nodes (middle third), and the superficial inguinal nodes (lower third).
Uterus
The uterus is the inverted, pear-shaped female reproductive organ that lies in the midline of the body, within the pelvis, between the bladder and the rectum.
The uterine wall comprises three layers: the perimetrium, the outer serous layer; the myometrium, the thick middle layer of smooth muscle; and the endometrium, the inner mucosal layer that undergoes cyclic changes during the menstrual cycle. [12]
The uterus is thick-walled and muscular, with a lining that, during reproductive years, changes in response to hormone stimulation throughout a woman’s monthly cycle.
The uterus can be divided into two parts: the most inferior aspect is the cervix, and the bulk of the organ is called the body of the uterus (corpus uteri). Between these two is the isthmus, a short area of constriction.
The body of the uterus is globe-shaped and is typically situated in an anteverted position, at a 90° angle to the vagina. The upper aspect of the body is dome-shaped and is called the fundus; it is typically the most muscular part of the uterus. The body of the uterus is responsible for holding a pregnancy, and strong uterine wall contractions help to expel the fetus during labor and delivery.
The average weight of a nonpregnant, nulliparous uterus is approximately 40-50 g. A multiparous uterus may weigh slightly more than this, with an upper limit of approximately 110 g. A menopausal uterus is small and atrophied and typically weighs much less.
The cavity of the uterus is flattened and triangular. The uterine tubes enter the uterine cavity bilaterally in the superolateral portion of the cavity.
The uterus is connected to its surrounding structures by a series of ligaments and connective tissue. The pelvic peritoneum is attached to the body and the cervix, forming the broad ligament and reflecting onto the bladder. The broad ligament attaches the uterus to the lateral pelvic side walls. Within the broad base of the broad ligament, between its anterior and posterior laminae, connective tissue strands associated with the uterine and vaginal vessels help to support the uterus and vagina. Together, these strands are referred to as the cardinal ligament.
Rectouterine ligaments, lying within peritoneal folds, stretch posteriorly from the cervix to reach the sacrum. The round ligaments of the uterus are much denser structures and connect the uterus to the anterolateral abdominal wall at the deep inguinal ring. They lie within the anterior lamina of the broad ligament. Within the round ligament is the artery of Sampson, a small artery that must be ligated during hysterectomy.
The vasculature of the uterus is derived from the uterine arteries and veins. The uterine vessels arise from the anterior division of the internal iliac, and branches of the uterine artery anastomose with the ovarian artery along the uterine tube.
The nerve supply and lymphatic drainage of the uterus are complex. Lymphatic drainage is primarily to the lateral aortic, pelvic, and iliac nodes that surround the iliac vessels. The nerve supply is attained through the sympathetic nervous system (by way of the hypogastric and ovarian plexuses) and the parasympathetic nervous system (by way of the pelvic splanchnic nerves from the second through fourth sacral nerves).
Cervix
The cervix is the inferior portion of the uterus, separating the body of the uterus from the vagina. The cervix is cylindrical in shape, with an endocervical canal located in the midline, allowing passage of semen into the uterus. The external opening into the vagina is termed the external os, and the internal opening into the endometrial cavity is termed the internal os. The internal os is the portion of a female cervix that dilates to allow delivery of the fetus during labor. The average length of the cervix is 3-5 cm.
The vasculature is supplied by descending branches of the uterine artery, which run bilaterally at the 3 o’clock and 9 o’clock position of the cervix. The nerve supply to the cervix is via the parasympathetic nervous system by way of the second through fourth sacral segments. Many pain nerve fibers run alongside these parasympathetics.
Lymphatic drainage of the cervix is complex. The obturator, common iliac, internal iliac, external iliac, and visceral parametrial nodes are the main drainage points. These lymphatic pathways are essential for understanding the spread of cervical cancers and are targeted in advanced cervical cancer treatments. [13]
The cervix is lined by two types of epithelium: the squamous epithelium, which covers the ectocervix (outer portion), and the columnar (glandular) epithelium, which lines the endocervical canal. The junction where these two epithelial types meet is called the squamocolumnar junction (SCJ). The area between the original SCJ and the new SCJ is known as the transformation zone (TZ). The cervix also has unique regions prone to cellular changes, particularly the TZ, where glandular and squamous cells meet. This area is frequently the origin of abnormal cell growth, making it crucial in cervical cancer screenings and human papillomavirus (HPV)-related disease management. [14]
Uterine tubes
The uterine tubes (also referred to as oviducts or fallopian tubes) are uterine appendages located bilaterally at the superior portion of the cavity. Their primary function is to transport sperm toward the egg, which is released by the ovary, and then to allow passage of the fertilized egg back to the uterus for implantation.
The uterine tubes exit the uterus through an area known as the cornua and form a connection between the endometrial and peritoneal cavities. Each tube is approximately 10 cm in length and 1 cm in diameter and is situated within a portion of the broad ligament called the mesosalpinx. The distal portion of the uterine tube ends in an orientation encircling the ovary.
The uterine tube has three parts. The first segment, closest to the uterus, is called the isthmus. The second segment is the ampulla, which becomes more dilated in diameter and is the typical place of fertilization. The final segment, furthest from the uterus, is the infundibulum. The infundibulum gives rise to the fimbriae, fingerlike projections that are responsible for catching the egg that is released by the ovary. From there, the egg travels through the ampulla, the site where fertilization by sperm most commonly occurs, before moving through the isthmus to reach the uterus. [3]
The fallopian tubes are situated within the broad ligament, specifically in the mesosalpinx region, and are lined with ciliated epithelial cells that, along with peristaltic contractions, help propel the egg toward the uterus. [3]
The arterial supply to the uterine tubes is from branches of the uterine and ovarian arteries, small vessels that are located within the mesosalpinx. The nerve supply to the uterine tubes is via both sympathetic and parasympathetic fibers. Sensory fibers run from thoracic segments 11-12 and lumbar segment 1. Lymphatic drainage of the uterine tubes is through the iliac and aortic nodes.
Ovaries
The ovaries are paired organs located on either side of the uterus within the mesovarium portion of the broad ligament below the uterine tubes. The ovaries are responsible for housing and releasing the ova, or eggs, necessary for reproduction. At birth, a female has approximately 1-2 million eggs, but only 300 of these eggs ever mature and are released for the purpose of fertilization.
The ovaries are small and oval-shaped, exhibit a grayish color, and have an uneven surface. The actual size of an ovary depends on a woman’s age and hormonal status; the ovaries are approximately 3-5 cm in length during childbearing years and become much smaller and atrophic once menopause occurs. A cross-section of the ovary reveals many cystic structures that vary in size. These structures represent ovarian follicles at different stages of development and degeneration.
The surface of the ovary is covered by a single layer of cuboidal epithelium called the germinal epithelium. Underneath this is a tough fibrous layer called the tunica albuginea. [15]
Several ligaments support the ovary. The ovarian ligament connects the uterus and ovary. The posterior portion of the broad ligament forms the mesovarium, which supports the ovary and houses the vascular supply. The suspensory ligament of the ovary (infundibulo pelvic ligament), a peritoneal fold overlying the ovarian vessels, attaches the ovary to the pelvic side wall.
Blood supply to the ovary is via the ovarian artery; both the right and left ovarian arteries originate directly from the descending aorta at the level of the L2 vertebra. The ovarian artery and vein enter and exit the ovary at the hilum. The left ovarian vein drains into the left renal vein, and the right ovarian vein empties directly into the inferior vena cava.
Nerve supply to the ovaries runs with the vasculature within the suspensory ligament of the ovary, entering the ovary at the hilum. Supply is through the ovarian, hypogastric, and aortic plexuses. Lymphatic drainage of the ovary is primarily to the lateral aortic nodes; however, the iliac nodes may also be involved.
The size and appearance of the ovaries change throughout a woman’s lifetime. Newborn ovaries are small, measuring about 1.3 x 0.6 x 0.4 cm. Before the first menstrual period, they are about one third the size of adult ovaries. They gradually enlarge with growth, reaching an average size of 4 x 2 x 3 cm in reproductive-age women. During pregnancy, they more than double in size. After menopause, they shrink significantly, potentially to as small as 2 cm. [16, 1]
The concept of ovarian reserve refers to the capacity of the ovary to provide oocytes that are capable of being fertilized. The anti-Müllerian hormone levels are key predictors for assessing the ovarian reserve. [17]
Labia
The labia majora are two large, longitudinal folds of adipose and fibrous tissue. They vary in size and distribution from female to female, and the size is dependent upon adipose content. They extend from the mons anteriorly to the perineal body posteriorly. The labia majora have hair follicles on the external pigmented surface. The internal surface is smooth and bears large sebaceous follicles. Loose connective and adipose tissue intermixed with smooth muscle (resembling the dartos muscle of the scrotum) is present between these surfaces. [1]
The labia minora, also known as nymphae, are two small cutaneous folds that are found between the labia majora and the introitus or vaginal vestibule. Anteriorly, the labia minora join to form the frenulum of the clitoris.
The female reproductive system is a complicated but fascinating subject. It has the capability to function intimately with nearly every other body system for the purpose of reproduction.
The female reproductive organs can be subdivided into the internal and external genitalia (see the images below). The internal genitalia are those organs that are within the true pelvis. These include the vagina, uterus, cervix, uterine tubes (oviducts or fallopian tubes), and ovaries. The vulva and vagina constitute the lower genital tract, while the upper genital tract consists of the uterus and cervix with the associated uterine (fallopian) tubes and ovaries. [1]
The uterus, a highly specialized muscular organ, is structured to support and sustain the development of a fetus during pregnancy. It also facilitates its expulsion during parturition through coordinated contractions. The cervix, situated at the lower end of the uterus, serves as a crucial anatomical gateway between the uterus and the vagina. [1]
The external genitalia lie outside the true pelvis. These include the perineum, mons pubis, clitoris, urethral (urinary) meatus, labia majora and minora, vestibule, greater vestibular (Bartholin) glands, Skene glands, and periurethral area.
These glands produce lubricating secretions that maintain a healthy environment in the vaginal and periurethral area. The mons pubis, which is located above the pubic bone, and the perineum, which lies between the vulva and the anus, provide additional protection to the underlying structures. The clitoris, rich in nerve endings, is a primary source of sexual pleasure. [1]
The female reproductive system undergoes significant physiological changes across life stages, from puberty through menopause, reflecting its adaptability and integration with other body functions. The hormone-regulated menstrual cycle prepares the body each month for potential pregnancy, showcasing the system’s synchronization with the endocrine system. [1]
