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Pathology > Female Reproductive System And Breast > Flashcards

Female Reproductive System And Breast Flashcards

1
Q

An inflammatory disease characterized by pruritus and dyspareunia and grossly manifests with white plaques and atrophic skin with a “parchment paper” quality.

A

Lichen sclerosus

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2
Q

Lichen sclerosus may be a precursor of what carcinoma

A

Squamous cell carcinoma

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3
Q

The most common form of vaginitis.

A

Candidiasis (moniliasis)

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4
Q

Characterized by white, patch-like mucosal lesions, a thick white discharge, and vulvovaginal pruritus.

A

Candidiasis

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5
Q

The major causative agent for bacterial vaginosis

A

Gardnerella

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6
Q

The most common cause of vaginal discharge.

A

Bacterial vaginosis (Gardnerella vaginitis)

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7
Q

Characteristically, it is a thin, homogeneous vaginal discharge with a malodorous, fishy amine odor, especially on addition of 10% potassium hydroxide.

A

Bacterial vaginosis (Gardnerella vaginitis)

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8
Q

“Clue cells” in the Pap smear

A

Bacterial vaginosis

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9
Q

Causative agent of Lymphogranuloma venereum

A

C. trachomatis L1, L2, or L3 serotypes

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10
Q

Manifests initially as a small papule or ulcer, followed by superficial ulcers and enlargement of regional lymph nodes, which become matted together. It can lead to rectal stricture as a result of inflammatory reaction and scarring.

A

Lymphogranuloma venereum

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11
Q

An infection of the vulva and vagina with the pathognomonic histologic findings of cells with the three “Ms”: multinucleation, nuclear molding, and margination of the chromatin.

A

Herpes simplex virus (HSV) infections

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12
Q

Causative agent for chancroid

A

Haemophilus ducreyi

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13
Q

Vulvar or vaginal infection that is characterized by a soft and painful ulcerated lesion

A

Chancroid

in contrast to the chancre of syphilis, which is firm and painless.

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14
Q

Causative agent for granuloma inguinale

A

Calymmabacterium (Donovania) granulomatis

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15
Q

Donovan bodies are seen in

A

Granuloma inguinale

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16
Q

The most common benign tumor of the vulva.

A

Papillary hidradenoma

This tumor originates from apocrine sweat glands.

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17
Q

Koilocytes are seen in

A

Condyloma acuminatum

Expanded epithelial cells with perinuclear clearing

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18
Q

The most common malignant tumor of the vulva.

A

Squamous cell carcinoma

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19
Q

A benign condition characterized by mucosal columnar epithelium-lined crypts in areas normally lined by stratified squamous epithelium, and is thought to be a precursor of clear cell adenocarcinoma.

A

Vaginal adenosis

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20
Q

A rare variant of embryonal rhabdomyosarcoma with presenting features of multiple polypoid masses resembling a “bunch of grapes” projecting into the vagina, often protruding from the vulva.

A

Sarcoma botryoides

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21
Q

Cervicitis most often involves

A

Endocervix

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22
Q

4 HPV types that are frequently associated with cervical dysplasia or cancer

A

16, 18, 31, 33

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23
Q

Most common cervical cancer

A

SCC

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24
Q

Most common site of endometriosis

A

Ovary

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25
Q

Most common uterine tumor

A

Leiomyoma (fibroid)

26
Q

Most common tumor in women

A

Leiomyoma (fibroid)

27
Q

Characterized by islands of endometrium within myometrium

A

Adenomyosis

28
Q

The most common gynecologic malignancy

A

Endometrial carcinoma

29
Q

The most frequent benign tumor of the fallopian tubes.

A

Adenomatoid tumor

30
Q

The l“TICs” (tubal intraepithelial carcinomas), which are thought to be precursors for ovarian serous carcinomas, is associated with mutation in what gene

A

BRCA-1 mutations

31
Q

This cyst is due to distention of the unruptured graafian follicle.

A

Follicular cyst

32
Q

This cyst results from hemorrhage into a persistent mature corpus luteum.

A

Corpus luteum cyst

33
Q

This cyst results from gonadotropin stimulation; it can be associated with choriocarcinoma and hydatidiform mole.

A

Theca-lutein cyst

34
Q

This cyst is a blood-containing cyst resulting from ovarian endometriosis with hemorrhage.

A

Chocolate cyst

35
Q

This benign surface epithelial cystic ovarian tumor that is lined with cells similar to fallopian tube epithelium.

A

Serous cystadenoma

36
Q

Most common ovarian carcinoma

A

Serous cystadenocarcinoma

37
Q

Pseudomyxoma peritonei is a characteristic of what ovarian tumor

A

Mucinous cystadenocarcinoma

38
Q

High-grade malignancies and are the most common ovarian tumors seen in association with endometriosis

A

Clear cell carcinoma

39
Q

Rare, benign tumors that are characterized by small islands of epithelial cells resembling bladder transitional epithelium interspersed within a fibrous stroma

A

Brenner tumors

40
Q

Tumor analogous to testicular seminoma

A

Dysgerminoma

41
Q

Tumor marker of endodermal sinus or yolk sac tumor

A

Alpha fetoprotein

42
Q

Which is malignant? Immature teratoma or mature teratoma?

A

Immature

43
Q

Most common germ cell tumor

A

Mature teratoma (dermoid cyst).

44
Q

Most common monodermal teratoma cyst (contains only a single tissue element) that consists entirely of thyroid tissue and can be hyperfunctional, resulting in hyperthyroidism.

A

struma ovarii

45
Q

This solid tumor consists of bundles of spindle-shaped fibroblasts.

A

Fibroma

46
Q

A triad of ovarian fibroma, ascites, and hydrothorax.

A

Meigs syndrome

47
Q

Call exner bodies are diagnostic feature of

A

Granulosa cell tumor

48
Q

Ovaries are replaced bilaterally by mucin-secreting signet-ring cells

A

Krukenberg tumors

49
Q

Most common site of origin of Krukenberg tumors

A

Stomach

50
Q

The most common disorder of the breast

A

Fibrocystic disease

51
Q

This is the most common breast tumor in women younger than 25 years of age.

A

Fibroadenomaa

52
Q

Type of fibroadenoma of the breast wherein stroma compresses and distorts glands into slitlike spaces

A

Intracanalicular fibroadenoma

53
Q

Type of fibroadenoma of the breast wherein the glands retain round shape

A

Pericanalicular fibroadenoma

54
Q

Breast tumor characterized by cystic spaces containing leaflike projections from the cyst walls and myxoid contents

A

Phyllodes tumor

55
Q

Most frequent site of carcinoma in the breast

A

Upper outer quadrant

56
Q

Most common carcinoma of the breast

A

Invasive ductal carcinoma

57
Q

ER/PR + breast tumor have better or poorer prognosis?

A

Better

58
Q

Her-2/neu positive breast tumor have better or poorer prognosis?

A

Poorer

59
Q

Eczematoid lesion of the nipple or areola; with characteristic large cells surrounded by a clear halo-like area, invade the epidermis; underlying ductal carcinoma almost always present

A

Paget disease of the breast

60
Q

Breast tumor that is often multicentric or bilateral; tends to have cells arranged in a linear fashion (“Indian-file” appearance)

A

Invasive lobular carcinoma

Pathology (8 decks)

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