FINAL

Question 1

Long - Acting Anti- inflammatory

Cromolyn

Answer 1

• Inhaled via nebulizer
• MOA: inhibits mast cell degranulation
• AE: Throat irritation, cough

Question 2

Anti-inflammatory Corticosteroids

• Beclomethasone
• Prednisolone

Answer 2

• Inhaled (most common), oral
• MOA: Decrease synthesis of inflammatory mediators
• Used to improve breathing with Pt dealing with asthma
• AE: oropharyngeal candidiasis, dysphonia
• Oral AE: hypokalemia, hyperglycemia, adrenal suppression (prolonged use), Cushing-like syndrome

NI:
- evaluate for thrush with prolonged use
- have pt rinse mouth after use
- monitor for glood glucose

Question 3

Methylxanthines

Theophylline

Answer 3

• MOA: Dilate bronchial smooth muscle by inhibiting PDE3/4
• AE: Narrow therapeutic window, interacts with everything (caffeine)
• Tachycardia -> convulsions and death
• DDI B2 agonist (excessive tachycardia)
• Monitor HR
• Monitor blood levels (narrow therapeutic window)

Question 4

Short acting B2 Agonist

Albuterol

Answer 4

• MOA: Dilate bronchial Smooth muscle
• AE: tachycardia, angina
• monitor HR

Question 5

Long acting B2 Agonist

Salmeterol

Answer 5

• MA: Dilate bronchial Smooth muscle
• AE: asthma related death (monotherapy), tachycardia/dysrhythmias, tolerance

Question 6

Muscarinic Antagonist

Short acting: Ipratropium

Long acting: Tiotropium

Answer 6

• MAE: bronchodilation by antagonizing muscarinic receptors in the lung
• AE: dry mouth

Question 7

Anti-leukotrienes

• Zafirlukast
• Montelukast

Answer 7

• Oral administration
• MAE: suppress inflammatory action of leukotrienes
• AE: risk of depression

Question 8

Biologics

Omalizumab

Answer 8

• Injected SubQ
• MA: antagonist of IgE (the allergen immunoglobulin)
• AE: injection-site reactions, increased risk of infection