Final Flashcards

(50 cards)

1
Q
  1. Human papilloma virus infection (HPV) is pathogenetically associated with:
    (A) Melanoma
    (B) Bronchogenic carcinoma
    (C) Carcinoma of cervix and esophageal cancer
    (D) Carcinoma of the stomach
    (E) Mesothelioma
A

(C) Carcinoma of cervix and esophageal cancer

  • HPV types 16 and 18
  • Mesothelioma - associated with asbestos
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2
Q
  1. An 18 yo presents with a well-circumscribed 2-cm mass in her right breast. The mass is painless and has a
    rubbery consistency and discrete borders. It appears to move freely through the breast tissue. What is the likeliest diagnosis?
    (A) Carcinoma
    (B) Cyst
    (C) Fibroadenoma
    (D) Cystosarcoma phyllodes
    (E) Intramammary lymph node
A

(C) Fibroadenoma

  • Most common benign breast tumor in young women
  • Fibroadenomas are common, benign, mobile, well-circumscribed, and rubbery
  • Cyst are typically not rubbery or mobile
  • Carcinomas are harder, fixed and maybe painful
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3
Q
  1. Which of the following factors has NOT shown to increase a woman’s risk for breast cancer?
    (A) Human papilloma virus infection (HPV)
    (B) Previous history of benign breast biopsies
    (C) Atypia seen on pathology from previous breast cancer
    (D) First-degree relative with history of breast cancer
    (E) Increasing age
A

(A) Human papilloma virus infection (HPV)

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4
Q
  1. Which of the following statements regarding lung cancer is NOT true?
    (A) Lung cancer is the most common cause of cancer-related death in both women and man.
    (B) Small-cell lung cancer has a relatively good prognosis compared to non-small-cell lung cancer
    (C) Bronchogenic carcinoma is seen predominantly in men between the ages of 55 and 60.
    (D) Cough is principal presenting symptom.
    (E) Hemoptysis is seen in half of all patients
A

(B) Small-cell lung cancer has a relatively good prognosis compared to non-small-cell lung cancer

  • Small cell lung cancer spreads rapidly and has poor prognosis
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5
Q
  1. Postoperative chemotherapy for colon cancer is recommended for patients with:
    (A) Dukes’E
    (B) Dukes’A
    (C) Dukes’B
    (D) Dukes’C
    (E) Dukes’D
A

(D) Dukes’C

  1. Dukes’ A: Early, local—surgery is enough.
  2. Dukes’ B: May need chemo if high-risk features.
  3. Dukes’ C involves lymph nodes, needs adjuvant chemo.
  4. Dukes’ D: Advanced/metastatic, palliative chemo used
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6
Q
  1. A patient presents with a pigmented nevus. You perform an excisional biopsy and send it for microscopic
    analysis. You would expect an almost 95% cure rate with simple excision alone if the Breslow level was:
    (A) < 1mm
    (B) > 2,1mm
    (C) > 2,5mm
    (D) < 2,7mm
    (E) > 4mm
A

(A) < 1mm

  • increasing depth = worse prognosis
  • <1mm - high survival and cure with excision
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6
Q
  1. A 45 yo woman presents with bloody nipple discharge. The most likely cause of this problem is:
    (A) Fibrocystic breast disease
    (B) Intraductal papilloma
    (C) Pituitary tumor
    (D) Invasive ductal carcinoma
    (E) Lobular carcinoma
A

(B) Intraductal papilloma

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7
Q
  1. A 65 yo man presents with squamous cell carcinoma of the anus. He is in good health other wise. Metastatic
    workup is negative. The treatment of choice for this cancer is:
    (A) Radiotherapy
    (B) Chemotherapy
    (C) A&B
    (D) Abdomino-perineal resection
    (E) Wide local excision
A

(C) A&B

  • Nigro protocol (chemoradiotherapy) - standard
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8
Q
  1. Risk factors of melanoma include all of the following EXCEPT:
    (A) Exposure to sunlight
    (B) Family history of melanoma
    (C) Exposure to asbestos
    (D) Spitz nevi
    (E) Xeroderma pigmentosum
A

(C) Exposure to asbestos

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9
Q
  1. The sentinel lymph node (SNB) biopsy has rapidly become a standard procedure for patients with:
    (A) Ovarian cancer
    (B) Gastric and esophageal cancer
    (C) Melanoma and breast cancer
    (D) Lung cancer
    (E) Colon cancer
A

(C) Melanoma and breast cancer

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10
Q
  1. The characteristic features of a malignant tumor include the following EXCEPT:
    (A) Typically non-encapsulated
    (B) Pleomorphism correlates with the degree of maligancy
    (C) Often encapsulated
    (D) Histologically, malignant cells and their nuclei often vary widely in shape and size from the cells of origin
    tissue
    (E) Poorly defined, irregular outline due to local tissue invasion
A

(C) Often encapsulated

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11
Q
  1. Bronchogenic carcinoma:
    (A) May be a largely preventable disease
    (B) Has a 50% cure rate
    (C) Responds to tamoxifen
    (D) Is synonymous with “coin” lesion
    (E) Responds well to X-rays
A

(A) May be a largely preventable disease

  • strong link to smoking - prevention possible
  • prognosis is poor
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11
Q
  1. The marker used in the diagnosis and management of colorectal cancer is:
    (A) PSA
    (B) CA 15.3
    (C) CA 19.9
    (D) CEA and AFP
    (E) BRCA 1 and BRCA
A

(D) CEA and AFP

  • PSA: Prostate cancer
  • CA 15.3: Breast cancer
  • CA 19.9: Pancreatic/gastrointestinal
  • CEA is the main marker for colorectal cancer; AFP may also be elevated in some GI tumors
  • BRCA1/BRCA2: Breast and ovarian cancer.
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12
Q
  1. Risk factors of esophageal squamous cell carcinoma include all of the following EXCEPT:
    (A) Alcohol and tobacco use
    (B) Exposure to sunrays
    (C) HPV (Human papillomavirus - subtypes 16,18)
    (D) Pickled vegetables, smoked meats and fish
    (E) Hot liquids
A

(B) Exposure to sunrays

  • HPV 16 and 18
  • hot drinks = mucosal injury
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13
Q
  1. A middle-aged male developes unusual appearing mole on his upper back. He says that his wife has noted a
    recent change in its color and shape. The lesion measures 0.7 cm and has ill-delined margins and irregular
    pigmentation. The patient is otherwise healthy and takes no medication. Which of the following is the most
    appropriate next step in management?
    (A) Follow—up examination in 6 months
    (B) Cryotherapy witl1 liquid nitrogen
    (C) Shave biopsy
    (D) Incisional biopsy
    (E) Excisional biopsy
A

(E) Excisional biopsy

  • excisional biopsy - gold standard, allows assessment of depth
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13
Q
  1. A 40 yo woman consults a physician about a “mole” on her neck. The lesion is 2 cm in diameter and slightly irregular, and has a variegated dark red to brown to black color. Wide excision of the lesion demonstrates a malignant neoplasm that extends to a depth of 3 mm. This tumor would be most likely to stain for which of the following tumor markers?
    (A) Alpha-fetoprotein
    (B) CA—125
    (C) Leukocyte common antigen (LCA)
    (D) Prostate specific antigen (PSA)
    (E) S-100
A

(E) S-100

  • S-100 = classic immunohistochemsitry marker for melanoma
  • CA -125 - ovarian cancer marker
  • LCA - lymphoma marker
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14
Q
  1. Which of the following is not typical symptom of late-stage colorectal cancer:
    (A) Anemia
    (B) Change in bowel habits
    (C) Blood in stool
    (D) Weight loss
    (E) Cardiac arrhythmias
A

(E) Cardiac arrhythmias

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14
Q
  1. The characteristic features of radiotherapy include the following EXCEPT:
    (A) Primary cure for tumours technically difficult to remove (head, neck, larynx)
    (B) Adjuvant radiotherapy- is applied to local tissues and regional lymph nodes after (or occasionally before)
    surgery to eliminate micrometastases
    (C) Neoadjuvant radiotherapy- short time before surgery, enhances the cure rate for surgery or down-stages a
    cancer to make surgery possible
    (D) Brachytherapy - local application of radioisotopes
    (E) Widely used for renal cell carcinoma
A

(E) Widely used for renal cell carcinoma

  • RCC - radioresistant, surgery is preferred
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15
Q
  1. According to American Cancer Society (ACS) Guidelines, the optimal age to start colorectal cancer
    screening test is:
    (A) 25
    (B) 35
    (C) 60
    (D) 50
    (E) 40
A

(D) 50

  • A, B and E - too early unless high risk patient (FAP, IBD)
  • 60 - too late = delayed detection reduces outcomes
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16
Q
  1. Nowadays leading cause of cancer death worldwide is:
    (A) Ovarian cancer
    (B) Gastric cancer
    (C) Prostate cancer
    (D) Lung cancer
    (E) Breast cancer
A

(D) Lung cancer

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17
Q
  1. Epidemiologic features associated with increased risk of developing breast cancer include all the following
    EXCEPT:
    (A) Nulliparous state
    (B) First pregnancy occurring late in reproductive life
    (C) High fat diet
    (D) Trauma
    (E) Family history of breast cancer
A

(D) Trauma

  • Nulliparity - increased exposure to estrogen
  • Late first pregnancy also has longer exposure to hormones
17
Q
  1. Recommendations for early cancer detection include all of the following EXCEPT:
    (A) Regular visits to the general practitioner
    (B) Patient education
    (C) PET (Positron Emission Tomography)
    (D) Regular oncological consultation (in higher risk group)
    (E) Screening programs
A

(C) PET (Positron Emission Tomography)

  • PET = diagnostic tool, not for general population screening
  • reserved for staging/monitoring
18
Q
  1. Courvoisier’s sign is referred to:
    (A) Obstruction of the duct of Wirsung by carcinoma of the pancreas leading to gall bladder enlargement.
    (B) Obstruction of the common bile duct by carcinoma of the pancreas leading to gall bladder enlargement.
    (C) Obstruction of the duct of Santorini by carcinoma of the pancreas leading to gall bladder enlargement
    (D) Obstruction of the duodenum by carcinoma of the pancreas leading to gall bladder enlargement.
    (E) Obstruction of the hepatic duct by carcinoma of the pancreas leading to gall bladder enlargement.
A

(B) Obstruction of the common bile duct by carcinoma of the pancreas leading to gall bladder enlargement.

  • Courvoisier’s sign is a painless, enlarged gallbladder with jaundice, typically caused by obstruction of the common bile duct, usually by a pancreatic head carcinoma
19
Q
  1. A pain at the top of the left shoulder referred from diaphragmatic irritation is:
    (A) Kupffer sign.
    (B) Kussmaul’s sign.
    (C) Allen’s sign.
    (D) Kehr’s sign.
    (E) Goldflam’s sign.
A

(D) Kehr’s sign

  • due to blood/fluid in peritoneal cavity
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25. Murphy’s sign is referred to: (A) Tenderness in right epigastrium. (B) Tenderness in mid epigastrium. (C) Tenderness in left epigastrium. (D) Tenderness in right hypogastrium. (E) Tenderness in left hypogastrium.
(A) Tenderness in right epigastrium * sign for acute cholecystitis
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27. A 38 yo man is admitted to the hospital after sustaining a pulmonary embolism. The patient has a past medical history significant for two idiopathic deep venous thromboses and takes only an aspirin daily. Three hours ago, he developed acute shortness of breath, pleuritic chest pain, and palpitations. He was taken by ambulance to the hospital. In the emergency department, he was diagnosed with a pulmonary embolus on the basis of clinical signs and symptoms and a ventilation perfusion scan. He was started on IV unfractionated heparin at that time. Which of the following laboratory tests would be most appropriate to guide therapy with this drug? (A) Bleeding time (B) Factor Xa levels (C) Platelet count (D) Prothrombin time (PT) (E) Partial thromboplastin time (PTT)
(E) Partial thromboplastin time (PTT) * meausres intrinsic and common coagulation pathways affected by heparin
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26. Glasgow Coma Scale assesses one of the following: (A) Best tongue movement. (B) Presence of the Battle’s sign. (C) Best vocal response. (D) Best motor response. (E) The presence of Babinski sign
(D) Best motor response. ** GCS assesses three main components of a patient's neurologic function: Eye opening response Best motor response Best verbal (vocal) response
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28. A 16 yo boy is brought to ER after he was assaulted. Witnesses claim that he was hit on the head with a lead pipe, after which he was unconscious for several minutes. No seizure activity was witnessed. On arrival, he complains of a headache, particularly severe at the point where he was hit in the right frontoparietal region. On examination, he is found to have swelling and ecchymosis over this region. He is awake, alert, and fully oriented. A complete neurologic examination reveals no deficit. Plain radiographs of the skull show a linear, nondepressed skull fracture in the frontoparietal skull that crosses the groove of the medial meningeal artery. During the following hour, he becomes sleepier and begins to vomit. A repeat neurologic examination at that time reveals him to be lethargic but without weakness, numbness, paresthesia, or other focal deficit. What is the most likely cause of the neurologic deterioration? (A) Diffuse axonal injury (DAI) (B) Todd’s phenomenon (C) Subdural hematoma (D) Epidural hematoma (E) Trigeminal ganglion hematoma
(D) Epidural hematoma * Classic presentation is a "lucid interval": the patient is initially unconscious, then awake and lucid, then deteriorates due to expanding hematoma.
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29. A young male is brought to the hospital unconscious after being resuscitated in an ambulance from the site of a motor vehicle accident. No other history or information is available. On general inspection, he is found to have multiple bruises over his body and has a massively swollen left thigh. His vital signs are stable with HR of 120/min and BP 150/75 mm Hg and respiratory rate is 40/min He is obtunded and does not follow commands or open his eyes. He withdraws his left arm and leg from painful stimuli, but not his right. His left pupil is 3 mm in diameter, and it is sluggishly reactive to light, while his right is 5 mm in diameter and fixed. Corneal reflexes are present bilaterally. To avoid injury to his spinal cord by an unstable cervical spine, an order is issued to not perform testing of his doll’s eye reflex. Intracranial hemorrhage causing increased intracranial pressure is suspected, along with a right uncal herniation. What is the next step in management? (A) Intubation of his airway for hyperventilation and administration of intravenous mannitol (B) Immediate CT scanning of the brain to confirm the presence of the suspected intracranial hemorrhage (C) Intubation of his airway for hyperventilation and intravenous administration of corticosteroids (D) Immediately evacuation of the suspected intracranial hematoma (E) Controlled hypoventilation
(A) Intubation of his airway for hyperventilation and administration of intravenous mannitol * Hyperventilation reduces CO2, causing cerebral vasoconstriction, temporarily lowering ICP. * Mannitol (osmotic diuretic) reduces brain edema.
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30. A 30 yo man is injured in the tigh with a knife. What is the first mechanism responsible for hemostasis? (A) exitrinsic clotting system (B) vessel constriction (C) intrinsic clotting system (D) platelet activation (E) fibrinolytic system
(B) vessel constriction * Immediate vasoconstriction of injured blood vessel to reduce blood loss. * Extrinsic clotting system: Activated next, seconds later by tissue factor. * Intrinsic clotting system: Activated after extrinsic. * Platelet activation: Important but follows vasoconstriction
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31. A 55 yo woman after motor vehicle crash with associated head trauma. She withdraws to pain and is intubated for airway protection. In order to calculate the Glasgow Coma Scale score, which of the following components of the neurologic examination are necessary? (A) Motor response, verbal response, corneal reflexes (B) Motor response, eye opening, verbal response (C) Eye opening, pupillary light reflexes, motor response (D) Pupillary light reflexes, motor response, verbal response (E) Corneal reflexes, pupillary light reflexes, motor response
(B) Motor response, eye opening, verbal response
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32. A 55-year-old man involved in an automobile accident is unresponsive and is intubated. On arrival in the emergency department, he responds to painful stimulation. His systolic BP is 60 mm Hg, his HR is 140 bpm, his neck veins are distended, and his breath sounds are absent on the left side. Immediate management should involve which of the following? (A) CT scan of head (B) Insertion of an 18-gauge needle in the left second intercostal space (C) Pericardiocentesis (D) Peritoneal lavage (E) Insertion of a central venous line on the right side
(B) Insertion of an 18-gauge needle in the left second intercostal space * Signs indicate tension pneumothorax: - Unilateral absent breath sounds - Distended neck veins (jugular venous distension) - Hypotension and tachycardia ** Needle thoracostomy in the second intercostal space midclavicular line decompresses tension pneumothorax emergently = life-saving procedure before imaging or chest tube placement.
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33. A 50 yo patients sustains numerous injuries of the abdomen and lower extremities. During the perioperative period, patient is resuscitated with 11 L of Ringer’s lactate and 3 U of packed red blood cells (RBC). After initial improvement, patient develops severe dyspnoea on the second postoperative day. Which of the following is the most useful initial diagnostic test? (A) Computed tomography (CT) scan of abdomen. (B) Analysis of arterial blood gas. (C) Insertion of a central venous line. (D) Ventilation-perfusion scan. (E) Electrocardiogram (ECG)
(B) Analysis of arterial blood gas * Severe dyspnea post large-volume resuscitation raises suspicion for pulmonary complications such as fluid overload, ARDS, or pulmonary edema. * ABG is a quick, bedside test to assess oxygenation, ventilation, and acid-base status.
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34. On examination, patients presenting with appendicitis typically show maximal tenderness over which of the following? (A) Immediately above the umbilicus (B) Inguinal region (C) At a point between the outer one-third and inner two-thirds of a line between the umbilicus and the anterior superior iliac spine (D) At a point between the outer two-thirds and inner one-third of a line between the umbilicus and the anterior superior iliac spine (E) At the midpoint of a line between the umbilicus and the anterior superior iliac spine
(C) At a point between the outer one-third and inner two-thirds of a line between the umbilicus and the anterior superior iliac spine ** Point is called McBurney's point, classically the site of maximal tenderness in appendicitis. * Corresponds anatomically to the base of the appendix.
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Question 35-36: A young female patient presents on physical examination pain and tenderness in the right iliac fossa. Her last menstrual cycle was 2 weeks previously and findings on gynecologic examination and leukocyte count are normal. A provisional diagnosis of acute appendicitis is made. 35. Her white blood cell (WBC) count is 13,000 and temperature is 100.6°F. In ER the uncomplicated appendicitis is confirmed and laparoscopic appendectomy is offered. Which of the following concerning laparoscopic appendectomy is TRUE? (A) Wound complication rate is greater than with open technique. (B) Length of hospital stay is longer than with open technique. (C) Procedure cost is less than with open technique. (D) Return to full feeding is longer than with open technique. (E) It can be performed safely with minimal morbidity compared to open technique.
(E) It can be performed safely with minimal morbidity compared to open technique. ** Laparoscopic appendectomy is safe and associated with fewer complications and faster recovery. ** Generally has lower morbidity and less postoperative pain.
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36. Possible advantages of the laparoscopic techniques include all EXCEPT? (A) Post hospital recovery is shorter. (B) Less scar formation. (C) Less wound-related complications. (D) Longer operative time. (E) Treatment for nonappendical disease still possible.
(D) Longer operative time
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37. A young male patient is complaining of pain in the umbilical region that moves to the right iliac fossa. Which is a corroborative sign of acute appendicitis? (A) Referred pain in the right side with pressure on the left (Rovsing)sign (B) Increase of pain with testicular elevation (C) Relief of pain in lower abdomen with extension of thigh (D) Relief of pain in lower abdomen with internal rotation of right thigh (E) Hyperanesthesia in the right lower abdomen
(A) Referred pain in the right side with pressure on the left (Rovsing)sign * Rovsing’s sign: Pressing left lower quadrant increases pain in right lower quadrant—classic for appendicitis. ** Sign supports diagnosis by eliciting peritoneal irritation.
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38. Plain abdominal films reveal following EXCEPT: (A) Spleen. (B) Calcifications. (C) Bowels. (D) Gas in abnormal places. (E) Foreign bodies.
(A) Spleen ** Plain films show gas patterns, bowel outlines, calcifications, foreign bodies, and abnormal gas collections
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39. Which of the following is the most useful diagnostic procedure of upper gastrointestinal tract diseases: (A) ERCP. (B) USG. (C) CT. (D) EGD. (E) MRI
(D) EGD * gold standard for diagnosing most UGI diseases like ulcers, tumors, and bleeding * Esophagogastroduodenoscopy
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40. A 42 yo man has had recurrent symptoms of peptic ulcer disease for 3,5 years. Endoscopy reveals an ulcer located on the greater curvature of the stomach. A mucosal biopsy reveals Helicobacter. pylori. Choose a TRUE statement about H. pylori? (A) Active organisms can be discerned by serology. (B) It is protective against gastric carcinoma. (C) It is associated with chronic gastritis. (D) It causes gastric ulcer but not duodenal ulcer. (E) It can be detected by the urea breath test in <60% of cases.
(C) It is associated with chronic gastritis.
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41. An elderly patient has suffered from dysphagia for 4 years, which has become progressively worse. The patient also complaints of a sense of a lump on the left side of his neck, gurgling sounds during swallowing and regurgitation. What is the diagnosis? (A) Carcinoma of the esophagus (B) Foreign body in the esophagus (C) Plummer-Vinson (Kelly-Patteson) syndrome (D) Zenker’s diverticulum (E) Scleroderma
(D) Zenker’s diverticulum ** Zenker’s diverticulum is a pharyngoesophageal pouch causing dysphagia, regurgitation, neck lump, and gurgling sounds. Symptoms worsen gradually over years.
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42. A symptomatic patient has a barium swallow revealing a 3-cm Zenker’s diverticulum. The next step in management is? (A) H2 blockers (B) Anticholinergic drugs (C) Elemental diet (D) Watchful waiting (E) Surgery (cricopharyngeal myotomy and diverticulectomy)
(E) Surgery (cricopharyngeal myotomy and diverticulectomy)
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44. An elderly female is admitted to the hospital with a mild UGI hemorrhage that stopped spontaneously. She did not require transfusion. She had ingested large amounts of aspirin in the past 4 months to relieve the pain caused by severe back pain. Endoscopy reveals the presence of a duodenal ulcer and a biopsy is performed. What is the next step in the management of a duodenal ulcer associated with a positive biopsy for H. pylori? (A) H2 blockers (B) Bipolar electrocautery of the ulcer (C) Triple therapy (D) Photocoagulation (E) Elective surgery
(C) Triple therapy ** Triple therapy (PPI + 2 antibiotics) eradicates H. pylori, heals ulcer, and prevents recurrence.
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43. A patient is diagnosed with Boerhaave’s syndrome. Which of the following is the proper management? (A) IV antibiotics and total parenteral nutrition (TPN). (B) IV antibiotics and TPN, a chest tube and a nasogastric tube (C) IV antibiotics and TPN, and insertion of a nasogastric tube (D) Resuscitation and emergency surgery either by laparotomy or thoracotomy (E) Resuscitation and elective surgical intervention when the general status of the patient improves
(D) Resuscitation and emergency surgery either by laparotomy or thoracotomy ** Boerhaave’s is a full-thickness esophageal rupture requiring urgent surgical repair after resuscitation. Delay increases morbidity and mortality.
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45. Which of the following is not typical of acute pancreatitis: (A) Pancreatic calcifications on CT scanning (B) Gallstones on USG. (C) Plasma amylase peak. (D) Serum lipase peak. (E) Acute peripancreatic fluid collection on CT scanning.
(A) Pancreatic calcifications on CT scanning ** Pancreatic calcifications are typically seen in chronic pancreatitis
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46. Transmural inflammatory bowel disease is characteristic of: (A) Ulcerative colitis. (B) Crohn’s disease. (C) Both of them. (D) None of them. (E) Irritable bowel disease.
(B) Crohn’s disease.
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47. Rectal bleeding is characteristic of: (A) Ulcerative colitis. (B) Crohn’s disease. (C) Both of them. (D) None of them. (E) Irritable bowel disease.
(A) Ulcerative colitis.
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48. Diarrhea is characteristic of: (A) Ulcerative colitis. (B) Crohn’s disease. (C) Both of them. (D) None of them. (E) Irritable bowel disease
(C) Both of them.
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49. Bowel strictures and fistulas are characteristic of: (A) Ulcerative colitis. (B) Crohn’s disease. (C) Both of them. (D) None of them. (E) Irritable bowel disease.
(B) Crohn’s disease.
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50. Surgery is required: A) Commonly in Crohn’s disease. (B) In fulminant ulcerative colitis. (C) With evidence of dysplasia or malignancy in ulcerative colitis. (D) A,B,C are correct. (E) Only A is correct
(D) A,B,C are correct.